{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T03:51:49Z","timestamp":1767153109020,"version":"build-2238731810"},"reference-count":42,"publisher":"Portland Press Ltd.","issue":"5","license":[{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,5,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The study explored the effect of miR-30e-5p on nasopharyngeal carcinoma (NPC). MiR-30e-5p levels in NPC cancer and adjacent normal samples, in metastatic and non-metastatic cancer samples of NPC, and in NP69 cell and five NPC cell lines were determined by quantitative real-time polymerase chain reaction (qRT-PCR). The relationship between miR-30e-5p and MTA1 was confirmed by dual-luciferase reporter assay, Western blot and qRT-PCR. The viability, migration and invasion of 5-8F and 6-10B cells were determined by CCK-8, scratch test and transwell assays, respectively. The levels of migration-related proteins (vimentin and Snail) and invasion-related proteins (MMP2 and MMP3) in NPC cells were detected by Western blot. The results showed that low expression of miR-30e-5p was associated with HNSC cancer, NPC, metastasis of NPC and NPC cell lines. Overexpressed miR-30e-5p in HNSC cancer and NPC was predictive of a better prognosis of patients. In addition, the viability, migration and invasion were reduced by up-regulating miR-30e-5p in 5-8F cells, but promoted by down-regulated miR-30e-5p in 6-10B cells. MiR-30e-5p reversed the migration and invasion of NPC cells regulated by MTA1, and inhibited migration and invasion of NPC cells via regulating MTA1 expression.<\/jats:p>","DOI":"10.1042\/bsr20194309","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T05:20:51Z","timestamp":1590556851000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["MiR-30e-5p inhibits the migration and invasion of nasopharyngeal carcinoma via regulating the expression of MTA1"],"prefix":"10.1042","volume":"40","author":[{"given":"Weiqun","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, The Affiliated Hospital of Putian University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenfeng","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Xinxiang First People\u2019s Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haolin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Xinxiang First People\u2019s Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1284-9688","authenticated-orcid":false,"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Zaozhuang Municipal Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2020,5,27]]},"reference":[{"key":"2021111620111263600_B1","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.3727\/096504017X14835311718295","article-title":"Cyclin-Dependent Kinase Inhibitor 3 Promotes Cancer Cell Proliferation and Tumorigenesis in Nasopharyngeal Carcinoma by Targeting p27","volume":"25","author":"Wang","year":"2017","journal-title":"Oncol. 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