{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:37:51Z","timestamp":1753871871080,"version":"3.41.2"},"reference-count":5,"publisher":"Portland Press Ltd.","issue":"2","license":[{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In a recent article Wang et al. reported about a 9-year-old Chinese male with obesity, insulin resistance, acanthosis nigricans, hyperuricemia, and non-alcoholic fatty liver disease (NALFD) being attributed to the variant m.5802A&amp;gt;G in tRNA(Cys) (Bioscience Reports (2020) 40(1), BSR20192153). Pathogenicity of the variant was substantiated by documentation of perturbed stability and mobility of the tRNA(Cys). The interesting study has a number of shortcomings, which do not allow drawing conclusions as provided before they are solved. Obesity is multifactorial and many differential causes of mtDNA variants were not discussed or excluded.<\/jats:p>","DOI":"10.1042\/bsr20194502","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T11:27:04Z","timestamp":1580729224000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Letter to the Editor: Comments on \u201cObesity associated with a novel mitochondrial tRNACys m.5802A&amp;gt;G mutation in a Chinese family\u201d"],"prefix":"10.1042","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2839-7305","authenticated-orcid":false,"given":"Josef","family":"Finsterer","sequence":"first","affiliation":[{"name":"Krankenanstalt Rudolfstiftung, Messerli Institute, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2020,2,11]]},"reference":[{"key":"2021111620020083100_B1","doi-asserted-by":"publisher","first-page":"BSR20192153","DOI":"10.1042\/BSR20192153","article-title":"Obesity associated with a novel mitochondrial tRNACys 5802A&gt;G mutation in a Chinese family","volume":"40","author":"Wang","year":"2020","journal-title":"Biosci. Rep."},{"key":"2021111620020083100_B2","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.pediatrneurol.2017.12.005","article-title":"MERRF Classification: Implications for Diagnosis and Clinical Trials","volume":"80","author":"Finsterer","year":"2018","journal-title":"Pediatr. Neurol."},{"key":"2021111620020083100_B3","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1007\/s10072-019-03864-w","article-title":"Complex multisystem phenotype associated with the mitochondrial DNA m.5522G&gt;A mutation","volume":"40","author":"Nesti","year":"2019","journal-title":"Neurol. Sci."},{"key":"2021111620020083100_B4","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1111\/j.1468-1331.2004.00859.x","article-title":"Stress lactate in mitochondrial myopathy under constant, unadjusted workload","volume":"11","author":"Finsterer","year":"2004","journal-title":"Eur. J. Neurol."},{"key":"2021111620020083100_B5","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.compbiolchem.2011.03.001","article-title":"Error compensation of tRNA misacylation by codon-anticodon mismatch prevents translational amino acid misinsertion","volume":"35","author":"Seligmann","year":"2011","journal-title":"Comput. Biol. Chem."}],"container-title":["Bioscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20194502\/867505\/bsr-2019-4502.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20194502\/867505\/bsr-2019-4502.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T20:17:33Z","timestamp":1637093853000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/bioscirep\/article\/40\/2\/BSR20194502\/222030\/Letter-to-the-Editor-Comments-on-Obesity"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2,28]]}},"URL":"https:\/\/doi.org\/10.1042\/bsr20194502","relation":{},"ISSN":["0144-8463","1573-4935"],"issn-type":[{"type":"print","value":"0144-8463"},{"type":"electronic","value":"1573-4935"}],"subject":[],"published-other":{"date-parts":[[2020,2]]},"published":{"date-parts":[[2020,2]]},"article-number":"BSR20194502"}}