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HF models were established by inducing ischemia myocardial infarction (MI) through ligation of the left anterior descending artery in Sprague\u2013Dawley (SD) rats. MI-induced changes in hemodynamics and cardiac function were reversed by apelin-13 administration. The increases in the levels of collagen I, collagen III, \u03b1-smooth muscle actin (SMA), and transforming growth factor-\u03b2 (TGF-\u03b2) in the heart of MI rats and cardiac fibroblasts (CFs) treated with angiotensin (Ang) II were inhibited by apelin-13. The levels of PI3K and p-Akt increased in Ang II-treated CFs, and these increases were blocked by apelin-13. The PI3K overexpression reversed the effects of apelin-13 on Ang II-induced increases in collagen I, collagen III, \u03b1-SMA, and TGF-\u03b2, NADPH oxidase activity and superoxide anions in CFs. Apelin-13 reduced the increases in the levels of NADPH oxidase activity and superoxide anions in the heart of MI rats and CFs with Ang II treatment. The results demonstrated that apelin-13 improved cardiac dysfunction, impaired cardiac hemodynamics, and attenuated fibrosis of CFs induced by Ang II via inhibiting the PI3K\/Akt signaling pathway to inhibit oxidative stress.<\/jats:p>","DOI":"10.1042\/bsr20200040","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T07:40:52Z","timestamp":1585035652000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Apelin-13 alleviated cardiac fibrosis via inhibiting the PI3K\/Akt pathway to attenuate oxidative stress in rats with myocardial infarction-induced heart failure"],"prefix":"10.1042","volume":"40","author":[{"given":"Shan","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Children\u2019s Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Children\u2019s Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Children\u2019s Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Children\u2019s Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Children\u2019s Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Children\u2019s Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0150-2892","authenticated-orcid":false,"given":"Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University, Suzhou, China"},{"name":"Department of Anesthesiology, Suzhou Hospital (West District) Affiliated to Nanjing Medical University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2020,4,3]]},"reference":[{"key":"2021111620064714500_B1","first-page":"e28","article-title":"Heart disease and stroke statistics\u20132014 update: a report from the American Heart Association","volume":"129","author":"Go","year":"2014","journal-title":"Circulation"},{"key":"2021111620064714500_B2","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.ymthe.2018.11.011","article-title":"Therapeutic delivery of miR-148a suppresses ventricular dilation in heart failure","volume":"27","author":"Raso","year":"2019","journal-title":"Mol. 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