{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:16:27Z","timestamp":1787318187061,"version":"build-2736575974"},"reference-count":30,"publisher":"Portland Press Ltd.","issue":"7","license":[{"start":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Biliary atresia (BA) is a genetic and severe fibro-inflammatory obliterative cholangiopathy of neonates. Platelet-derived growth factor subunit A (PDGFA), as one of participants in liver fibrosis, the overexpression of PDGFA through DNA hypomethylation may lead to the development of BA, but the pathogenesis is still unclear. We conducted a large case\u2013control cohort to investigate the association of genetic variants in PDGFA with BA susceptibility in the Southern Chinese population (506 cases and 1473 controls). We observed that the G allele of rs9690350(G&amp;gt;C) in PDGFA was significantly associated with an increased risk of BA (OR = 1.24, 95% CI = 1.04\u20131.49, P=0.02). Additionally, the rs9690350 G allele increased the risk of non-cystic biliary atresia (OR = 1.26, 95% CI = 1.04\u20131.52, P=0.02) and was a genetic biomarker of severe manifestations after surgery. These findings indicate that the rs9690350 G allele is a PDGFA polymorphism associated with the risk of BA that may confer increased disease susceptibility.<\/jats:p>","DOI":"10.1042\/bsr20200068","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T06:37:29Z","timestamp":1594708649000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["<i>PDGFA<\/i>\n                    gene rs9690350 polymorphism increases biliary atresia risk in Chinese children"],"prefix":"10.1042","volume":"40","author":[{"given":"Fei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4854-4966","authenticated-orcid":false,"given":"Jixiao","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deli","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menglong","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0103-1672","authenticated-orcid":false,"given":"Huimin","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9556-0240","authenticated-orcid":false,"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2020,7,21]]},"reference":[{"key":"2021111620211817300_B1","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1053\/j.gastro.2013.01.022","article-title":"Evidence from human and zebrafish that GPC1 is a biliary atresia susceptibility gene","volume":"144","author":"Cui","year":"2013","journal-title":"Gastroenterology"},{"key":"2021111620211817300_B2","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1002\/wsbm.1303","article-title":"Genome-wide association studies in biliary atresia","volume":"7","author":"Ningappa","year":"2015","journal-title":"Wiley Interdiscip. 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