{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T11:38:17Z","timestamp":1769168297393,"version":"3.49.0"},"reference-count":59,"publisher":"Portland Press Ltd.","issue":"10","license":[{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,10,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background: Sphingosine-1-phosphate (S1P) plays a significant role in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).<\/jats:p>\n               <jats:p>Methods: We collected the plasma samples from 40 patients with AAV and 10 healthy volunteers. The plasma levels of S1P were tested by enzyme-linked immunosorbent assay (ELISA). The levels of serum creatinine (Scr) were tested by rate method, and then the estimated glomerular filtration rate (eGFR) of the patients was calculated from the Scr, age, and gender. Prothrombin time (PT), partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (FIB), fibrinogen reduction product (FDP), D-dimer and C-reactive protein (CRP) were tested by turbidimetric inhibition immunoassays. Platelets (PLTs) were tested by fluorescently labeled electrical impedance method.<\/jats:p>\n               <jats:p>Results: The plasma levels of S1P were significantly higher in AAV patients than in healthy volunteers. Correlation analysis showed that plasma levels of S1P were negatively correlated with glomerular filtration (P=0.022, r = \u22120.306), and positively correlated with circulating levels of Birmingham vasculitis activity score (BVAS), PLT and D-dimer, (P=0.004, r = 0.443; P&amp;lt;0.001, r = 0.654; P=0.006, r = 0.427). The 40 patients with AAV were classified into three groups: the thromboembolism group (with complications of cerebral infarction and myocardial infarction, n=6), cerebral ischemia group (n=4), and cerebral hemorrhage group (n=2). The plasma levels of S1P were highest in the thromboembolism group and lowest in the cerebral hemorrhage group (P=0.003).<\/jats:p>\n               <jats:p>Conclusions: Plasma levels of S1P were associated with circulating levels of D-dimer, PLT and BVAS in the patients with AAV. Hence, plasma S1P level can be used as a biomarker to predict coagulation-related complications in AAV.<\/jats:p>","DOI":"10.1042\/bsr20200157","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T08:52:05Z","timestamp":1603270325000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sphingosine-1-phosphate in anti-neutrophil cytoplasmic antibody-associated vasculitis: coagulation-related clinical indicators and complications"],"prefix":"10.1042","volume":"40","author":[{"given":"Kai-Li","family":"Wu","sequence":"first","affiliation":[{"name":"Renal Division, Department of Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Huhehot, Inner Mongolia 010050, China"},{"name":"Inner Mongolia Medical University, Huhehot, Inner Mongolia 010059, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-Hui","family":"Liang","sequence":"additional","affiliation":[{"name":"Inner Mongolia Medical University, Huhehot, Inner Mongolia 010059, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Ding","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Huhehot, Inner Mongolia 010050, China"},{"name":"Inner Mongolia Medical University, Huhehot, Inner Mongolia 010059, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo-Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Huhehot, Inner Mongolia 010050, China"},{"name":"Inner Mongolia Medical University, Huhehot, Inner Mongolia 010059, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9322-3881","authenticated-orcid":false,"given":"Jian","family":"Hao","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Huhehot, Inner Mongolia 010050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2020,10,30]]},"reference":[{"key":"2021111620313720500_B1","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1093\/rheumatology\/ker454","article-title":"The contrasting epidemiology of granulomatosis with polyangiitis (Wegener\u2019s) and microscopic polyangiitis","volume":"51","author":"Watts","year":"2012","journal-title":"Rheumatology"},{"key":"2021111620313720500_B2","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.atherosclerosis.2015.03.020","article-title":"SKI-II\u2013a sphingosine kinase 1 inhibitor\u2013exacerbates atherosclerosis in low-density lipoprotein receptor-deficient (LDL-R\u2212\/\u2212) mice on high cholesterol diet","volume":"240","author":"Pot\u00ec","year":"2015","journal-title":"Atherosclerosis"},{"key":"2021111620313720500_B3","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"2021111620313720500_B4","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s10157-013-0869-6","article-title":"Overview of the 2012 revised International Chapel Hill Consensus Conference nomenclature of vasculitides","volume":"17","author":"Jennette","year":"2013","journal-title":"Clin. Exp. Nephrol."},{"key":"2021111620313720500_B5","doi-asserted-by":"publisher","first-page":"7413","DOI":"10.4049\/jimmunol.1000675","article-title":"A novel mechanism of rapid nuclear neutrophil extracellular trap formation in response to Staphylococcus aureus","volume":"185","author":"Pilsczek","year":"2010","journal-title":"J. Immunol."},{"key":"2021111620313720500_B6","doi-asserted-by":"publisher","first-page":"e1000639","DOI":"10.1371\/journal.ppat.1000639","article-title":"Neutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against Candida albicans","volume":"5","author":"Urban","year":"2009","journal-title":"PLoS Pathog."},{"key":"2021111620313720500_B7","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1016\/j.micinf.2010.06.009","article-title":"NETs formed by human neutrophils inhibit growth of the pathogenic mold Aspergillus fumigatus","volume":"12","author":"McCormick","year":"2010","journal-title":"Microbes Infect."},{"key":"2021111620313720500_B8","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.berh.2009.03.001","article-title":"The diagnosis of vasculitis","volume":"23","author":"Jayne","year":"2009","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"2021111620313720500_B9","doi-asserted-by":"publisher","first-page":"R142","DOI":"10.1186\/ar4604","article-title":"The interaction between C5a and sphingosine-1-phosphate in neutrophils for antineutrophil cytoplasmic antibody mediated activation","volume":"16","author":"Hao","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"2021111620313720500_B10","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/365557a0","article-title":"Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens","volume":"365","author":"Olivera","year":"1993","journal-title":"Nature"},{"key":"2021111620313720500_B11","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1172\/JCI76369","article-title":"Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy","volume":"125","author":"Proia","year":"2015","journal-title":"J. Clin. Invest."},{"key":"2021111620313720500_B12","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1146\/annurev.biochem.78.072407.103733","article-title":"Sphingosine 1-phosphate receptor signaling","volume":"78","author":"Rosen","year":"2009","journal-title":"Annu. Rev. Biochem."},{"key":"2021111620313720500_B13","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.4049\/jimmunol.1000644","article-title":"Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-\u03b1\u2013induced arthritis","volume":"185","author":"Baker","year":"2010","journal-title":"J. Immunol."},{"key":"2021111620313720500_B14","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.3389\/fimmu.2018.02189","article-title":"Neuropsychiatric systemic lupus erythematosus is dependent on sphingosine-1-phosphate signaling","volume":"9","author":"Mike","year":"2018","journal-title":"Front. Immunol."},{"key":"2021111620313720500_B15","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1093\/ndt\/gfw427","article-title":"Sphingosine-1-phosphate and its receptors in anti-neutrophil cytoplasmic antibody-associated vasculitis","volume":"32","author":"Sun","year":"2017","journal-title":"Nephrol. Dialysis Transplant."},{"key":"2021111620313720500_B16","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1096\/fj.08-118109","article-title":"A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis","volume":"23","author":"Snider","year":"2009","journal-title":"FASEB J."},{"key":"2021111620313720500_B17","doi-asserted-by":"publisher","first-page":"391","DOI":"10.3390\/ijms19020391","article-title":"S1P signalling differentially affects migration of peritoneal B cell populations in vitro and influences the production of intestinal IgA in vivo","volume":"19","author":"Kleinwort","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"2021111620313720500_B18","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s11033-011-0750-1","article-title":"The sphingosine-1-phosphate receptor agonist FTY720 prevents the development of anti-glomerular basement membrane glomerulonephritis","volume":"39","author":"Sui","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"2021111620313720500_B19","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/1440-1681.12494","article-title":"Increased sphingosine 1-phosphate mediates inflammation and fibrosis in tubular injury in diabetic nephropathy","volume":"43","author":"Yaghobian","year":"2016","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"2021111620313720500_B20","doi-asserted-by":"publisher","first-page":"4550","DOI":"10.1111\/jcmm.13736","article-title":"Rho GTP ases are involved in S1P-enhanced glomerular endothelial cells activation with anti-myeloperoxidase antibody positive IgG","volume":"22","author":"Sun","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"2021111620313720500_B21","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s12865-019-0306-z","article-title":"Macrophage migration inhibitory factor is involved in antineutrophil cytoplasmic antibody-mediated activation of C5a-primed neutrophils","volume":"20","author":"Hao","year":"2019","journal-title":"BMC Immunol."},{"key":"2021111620313720500_B22","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/ki.2012.313","article-title":"Circulating complement activation in patients with anti-neutrophil cytoplasmic antibody\u2013associated vasculitis","volume":"83","author":"Gou","year":"2013","journal-title":"Kidney Int."},{"key":"2021111620313720500_B23","first-page":"1058","article-title":"Complement-first of two parts","volume":"344","author":"Complement","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"2021111620313720500_B24","doi-asserted-by":"publisher","first-page":"e66305","DOI":"10.1371\/journal.pone.0066305","article-title":"A pro-inflammatory role of C5L2 in C5a-primed neutrophils for ANCA-induced activation","volume":"8","author":"Hao","year":"2013","journal-title":"PLoS ONE"},{"key":"2021111620313720500_B25","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1681\/ASN.2008050497","article-title":"C5a receptor mediates neutrophil activation and ANCA-induced glomerulonephritis","volume":"20","author":"Schreiber","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"2021111620313720500_B26","doi-asserted-by":"publisher","first-page":"52","DOI":"10.2353\/ajpath.2007.060573","article-title":"Alternative complement pathway in the pathogenesis of disease mediated by anti-neutrophil cytoplasmic autoantibodies","volume":"170","author":"Xiao","year":"2007","journal-title":"Am. J. Pathol."},{"key":"2021111620313720500_B27","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1160\/TH17-03-0219","article-title":"Protease-activated receptor PAR-4: an inducible switch between thrombosis and vascular inflammation?","volume":"117","author":"Fender","year":"2017","journal-title":"Thromb. Haemost."},{"key":"2021111620313720500_B28","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1111\/jcmm.13458","article-title":"Sphingosine-1-phosphate (S1P) enhances glomerular endothelial cells activation mediated by anti-myeloperoxidase antibody-positive IgG","volume":"22","author":"Sun","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"2021111620313720500_B29","doi-asserted-by":"publisher","first-page":"i53","DOI":"10.1093\/ndt\/gfu379","article-title":"Activation of endothelium, coagulation and fibrinolysis is enhanced and associates with renal anti-neutrophil cytoplasmic antibody-associated vasculitis","volume":"30","author":"Salmela","year":"2014","journal-title":"Nephrol. Dialysis Transplant."},{"key":"2021111620313720500_B30","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1093\/rheumatology\/ken035","article-title":"Venous thromboembolism in ANCA-associated vasculitis-incidence and risk factors","volume":"47","author":"Stassen","year":"2008","journal-title":"Rheumatology"},{"key":"2021111620313720500_B31","first-page":"671","article-title":"Birmingham vasculitis activity score (BVAS) Dim system necrotizinig vasculitis","volume":"87","author":"Luqmani","year":"1994","journal-title":"QJM"},{"key":"2021111620313720500_B32","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1161\/CIRCRESAHA.107.165845","article-title":"Vascular endothelium as a contributor of plasma sphingosine 1-phosphate","volume":"102","author":"Venkataraman","year":"2008","journal-title":"Circ. Res."},{"key":"2021111620313720500_B33","doi-asserted-by":"publisher","first-page":"160S","DOI":"10.1378\/chest.08-0670","article-title":"Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians evidence-based clinical practice guidelines","volume":"133","author":"Ansell","year":"2008","journal-title":"Chest"},{"key":"2021111620313720500_B34","doi-asserted-by":"crossref","first-page":"864","DOI":"10.4065\/82.7.864","article-title":"How to interpret and pursue an abnormal prothrombin time, activated partial thromboplastin time, and bleeding time in adults","volume":"82","author":"Kamal","year":"2007","journal-title":"Mayo Clin. Proc."},{"key":"2021111620313720500_B35","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1136\/jcp.38.4.480-a","article-title":"Human blood coagulation, haemostasis, and thrombosis","volume":"38","author":"Story","year":"1985","journal-title":"Journal of Clinical Pathology"},{"key":"2021111620313720500_B36","first-page":"1","article-title":"Studies on the determination of fibrinogen in human blood plasma","volume":"7","author":"Jacobsson","year":"1955","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"2021111620313720500_B37","first-page":"892","article-title":"Fibrin\/fibrinogen degradation products (FDP)","volume":"48","author":"Kuroso","year":"1989","journal-title":"Jpn. J. Clin. Med."},{"key":"2021111620313720500_B38","article-title":"Use of anticoagulants in diagnostic laboratory investigations","author":"World Health Organization","year":"2002","journal-title":"World Health Organization"},{"key":"2021111620313720500_B39","first-page":"18","article-title":"C-reactive protein: a marker of infection, inflammation, tissue damage and malignancy","volume":"28","author":"Rosen","year":"1990","journal-title":"Diag. Clin. Test."},{"key":"2021111620313720500_B40","first-page":"129","article-title":"Evaluation and clinical usefulness of the automated hematology analyzer, Sysmex XE-2100\u2227 T\u2227 M","volume":"9","author":"Tsuruda","year":"1999","journal-title":"Sysmex J. Int."},{"key":"2021111620313720500_B41","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1055\/s-0038-1646582","article-title":"Binding properties of monoclonal antibodies against human fragment D-dimer of cross-linked fibrin to human plasma clots in an in vivo model in rabbits","volume":"61","author":"Holvoet","year":"1989","journal-title":"Thromb. Haemost."},{"key":"2021111620313720500_B42","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1681\/ASN.2006040368","article-title":"Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease","volume":"17","author":"Ma","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"2021111620313720500_B43","doi-asserted-by":"publisher","first-page":"e97843","DOI":"10.1371\/journal.pone.0097843","article-title":"Coagulation and fibrinolysis index profile in patients with ANCA-associated vasculitis","volume":"9","author":"Ma","year":"2014","journal-title":"PLoS ONE"},{"key":"2021111620313720500_B44","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/nature24053","article-title":"Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets","volume":"550","author":"Vu","year":"2017","journal-title":"Nature"},{"key":"2021111620313720500_B45","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/nrc2875","article-title":"Sphingosine 1-phosphate and cancer","volume":"10","author":"Pyne","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"2021111620313720500_B46","doi-asserted-by":"publisher","first-page":"6394","DOI":"10.4049\/jimmunol.169.11.6394","article-title":"Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents","volume":"169","author":"MacKinnon","year":"2002","journal-title":"J. Immunol."},{"key":"2021111620313720500_B47","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1093\/cvr\/cvp088","article-title":"Regulation of vascular physiology and pathology by the S1P2 receptor subtype","volume":"82","author":"Skoura","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"2021111620313720500_B48","doi-asserted-by":"publisher","first-page":"237","DOI":"10.3389\/fimmu.2019.00237","article-title":"Thrombin contributes to anti-myeloperoxidase antibody positive IgG-mediated glomerular endothelial cells activation through SphK1-S1P-S1PR3 signaling","volume":"10","author":"Sun","year":"2019","journal-title":"Front. Immunol."},{"key":"2021111620313720500_B49","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1111\/j.1523-1755.2005.00679.x","article-title":"Characteristics of Chinese patients with Wegener's granulomatosis with anti-myeloperoxidase autoantibodies","volume":"68","author":"Chen","year":"2005","journal-title":"Kidney Int."},{"key":"2021111620313720500_B50","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1002\/art.38621","article-title":"Predictors of treatment resistance and relapse in antineutrophil cytoplasmic antibody\u2013associated vasculitis: a study of 439 cases in a single Chinese center","volume":"66","author":"Li","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"2021111620313720500_B51","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1161\/01.CIR.0000089190.95415.9F","article-title":"New markers of inflammation and endothelial cell activation: part I","volume":"108","author":"Szmitko","year":"2003","journal-title":"Circulation"},{"key":"2021111620313720500_B52","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1007\/s00210-015-1159-5","article-title":"FTY720 and two novel butterfly derivatives exert a general anti-inflammatory potential by reducing immune cell adhesion to endothelial cells through activation of S1P 3 and phosphoinositide 3-kinase","volume":"388","author":"Imeri","year":"2015","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"2021111620313720500_B53","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.molimm.2012.10.041","article-title":"Involvement of protein kinase C in C5a-primed neutrophils for ANCA-mediated activation","volume":"54","author":"Hao","year":"2013","journal-title":"Mol. Immunol."},{"key":"2021111620313720500_B54","doi-asserted-by":"publisher","first-page":"e38317","DOI":"10.1371\/journal.pone.0038317","article-title":"p38MAPK, ERK and PI3K signaling pathways are involved in C5a-primed neutrophils for ANCA-mediated activation","volume":"7","author":"Hao","year":"2012","journal-title":"PLoS ONE"},{"key":"2021111620313720500_B55","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.2215\/CJN.00120115","article-title":"Association of serum C3 concentration and histologic signs of thrombotic microangiopathy with outcomes among patients with ANCA-associated renal vasculitis","volume":"10","author":"Manenti","year":"2015","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"2021111620313720500_B56","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/nrneph.2017.37","article-title":"Complement in ANCA-associated vasculitis: mechanisms and implications for management","volume":"13","author":"Chen","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"key":"2021111620313720500_B57","doi-asserted-by":"publisher","first-page":"4794","DOI":"10.4049\/jimmunol.177.7.4794","article-title":"A novel C5a receptor-tissue factor cross-talk in neutrophils links innate immunity to coagulation pathways","volume":"177","author":"Ritis","year":"2006","journal-title":"J. Immunol."},{"key":"2021111620313720500_B58","doi-asserted-by":"publisher","first-page":"e99386","DOI":"10.1371\/journal.pone.0099386","article-title":"Platelet activation and anti-phospholipid antibodies collaborate in the activation of the complement system on platelets in systemic lupus erythematosus","volume":"9","author":"Lood","year":"2014","journal-title":"PLoS ONE"},{"key":"2021111620313720500_B59","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1177\/039139880202500606","article-title":"The effect of heparin rinse on the biocompatibility of continuous veno-venous hemodiafiltration","volume":"25","author":"Opatrn\u00fd","year":"2002","journal-title":"Int. J. Artif. Organs"}],"container-title":["Bioscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20200157\/896279\/bsr-2020-0157.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20200157\/896279\/bsr-2020-0157.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T20:58:06Z","timestamp":1637096286000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/bioscirep\/article\/40\/10\/BSR20200157\/226723\/Sphingosine-1-phosphate-in-anti-neutrophil"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":59,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10,30]]}},"URL":"https:\/\/doi.org\/10.1042\/bsr20200157","relation":{},"ISSN":["0144-8463","1573-4935"],"issn-type":[{"value":"0144-8463","type":"print"},{"value":"1573-4935","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,10]]},"published":{"date-parts":[[2020,10]]},"article-number":"BSR20200157"}}