{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:21:54Z","timestamp":1777983714814,"version":"3.51.4"},"reference-count":26,"publisher":"Portland Press Ltd.","issue":"4","license":[{"start":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T00:00:00Z","timestamp":1586390400000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,4,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Expression of proinflammatory cytokines, such as interleukin (IL)-6 (IL-6) and metalloproteases, are elevated in patients with rotator cuff tear (RCT). In order to investigate the role of IL-6 gene polymorphisms on RCT risk, we genotyped two SNPs on IL-6 gene (rs1800795 and rs1800797) in 138 RCT patients and 137 healthy controls using polymerase chain reaction (PCR) and Sanger sequencing. The IL-6 expression in shoulder joint synovial fluid was determined by using enzyme-linked immunosorbent assay (ELISA) method. The constant score and visual analog scale (VAS) were used to evaluate the clinical outcome of two s (surgicsal vs. conservative) for RCT patients. For rs1800795, individuals with the GG genotype or G allele had significantly higher risk of RCT. Elevated risk of tear size was associated with the GG genotype of the rs1800795 polymorphism. The IL-6 rs1800797 polymorphism was also associated with an increased risk of RCT, especially among female, drinkers, and individuals with B(MI) &amp;lt; 25 kg\/m2. The elevated levels of IL-6 gene were observed among the mutant genotype of rs1800795\/rs1800797 polymorphism. Surgical group is significantly better than conservative treatment from the perspective of constant score and VAS. Furthermore, CG genotype of rs1800795 polymorphism increased the constant score at 6 months in comparison with CC genotype. In conclusion, our study supports a role of IL-6 rs1800795\/rs1800797 polymorphisms on increased RCT risk. The RCT patients with CG genotype of rs1800795 polymorphism have more obvious surgical treatment effects by influencing the IL-6 expression.<\/jats:p>","DOI":"10.1042\/bsr20200193","type":"journal-article","created":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T06:58:25Z","timestamp":1586415505000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The association between\n                    <i>Interleukin-6<\/i>\n                    rs1800795\/rs1800797 polymorphisms and risk of rotator cuff tear in a Chinese population"],"prefix":"10.1042","volume":"40","author":[{"given":"Jin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing 314000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifeng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xindie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Affiliated Changzhou No.2 People\u2019s Hospital of Nanjing Medical University, Changzhou 213000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Trauma Center, The Affiliated Changzhou No.2 People\u2019s Hospital of Nanjing Medical University, Changzhou 213000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1164-7355","authenticated-orcid":false,"given":"Gang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing 314000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2020,4,21]]},"reference":[{"key":"2021111620080485100_B1","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1136\/bmj.331.7525.1124","article-title":"Shoulder pain: diagnosis and management in primary care","volume":"331","author":"Mitchell","year":"2005","journal-title":"BMJ"},{"key":"2021111620080485100_B2","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1097\/00003086-199411000-00015","article-title":"Determinants of outcome in the treatment of rotator cuff disease","volume":"308","author":"Bartolozzi","year":"1994","journal-title":"Clin. 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