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Despite great advances in the comprehension of the pathogenesis and improvements in neonatal intensive care and associated medicine, preterm birth-related diseases remain essentially without adequate treatment and can lead to high morbidity and mortality. The therapeutic potential of mesenchymal stem\/stromal cells (MSCs) appears promising as evidenced by their efficacy in preclinical models of pathologies relevant to premature infant complications. MSC-based therapeutic efficacy is closely associated with MSC secretomes and a subsequent paracrine action response to tissue injuries, which are complex and abundant in response to the local microenvironment. In the current review, we summarize the paracrine mechanisms of MSC secretomes underlying diverse preterm birth-related diseases, including PVL, BPD, NEC and ROP, are summarized, and focus is placed on MSC-conditioned media (CM) and MSC-derived extracellular vesicles (EVs) as key mediators of modulatory action, thereby providing new insights for future therapies in newborn medicine.<\/jats:p>","DOI":"10.1042\/bsr20200241","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T13:18:34Z","timestamp":1587561514000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Mesenchymal stem cell-derived secretomes for therapeutic potential of premature infant diseases"],"prefix":"10.1042","volume":"40","author":[{"given":"Yu","family":"Wang","sequence":"first","affiliation":[{"name":"Women\u2019s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing 210004, China"},{"name":"Department of Neonatology, Changzhou Maternity and Child Health Care Hospital of Nanjing Medical University, Changzhou 213000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Long","sequence":"additional","affiliation":[{"name":"Women\u2019s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing 210004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Cao","sequence":"additional","affiliation":[{"name":"Women\u2019s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing 210004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyun","family":"Li","sequence":"additional","affiliation":[{"name":"Women\u2019s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing 210004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4313-6114","authenticated-orcid":false,"given":"Lianghui","family":"You","sequence":"additional","affiliation":[{"name":"Women\u2019s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing 210004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuru","family":"Fan","sequence":"additional","affiliation":[{"name":"Women\u2019s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing 210004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2020,5,7]]},"reference":[{"key":"2021111620093216900_B1","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S0140-6736(08)60074-4","article-title":"Epidemiology and causes of preterm birth","volume":"371","author":"Goldenberg","year":"2008","journal-title":"Lancet"},{"key":"2021111620093216900_B2","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1056\/NEJMra0904308","article-title":"The enigma of spontaneous preterm birth","volume":"362","author":"Muglia","year":"2010","journal-title":"N. 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