{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T19:40:36Z","timestamp":1776973236217,"version":"3.51.4"},"reference-count":69,"publisher":"Portland Press Ltd.","issue":"6","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,6,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Objective: To explore the mechanism of Shengmai Yin (SMY) for coronary heart disease (CHD) by systemic pharmacology and chemoinformatics.<\/jats:p>\n               <jats:p>Methods: Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), traditional Chinese medicine integrative database (TCMID) and the traditional Chinese medicine (TCM) Database@Taiwan were used to screen and predict the bioactive components of SMY. Pharmmapper were utilized to predict the potential targets of SMY, the TCMSP was utilized to obtain the known targets of SMY. The Genecards and OMIM database were utilized to collect CHD genes. Cytoscape was then used for network construction and analysis, and DAVID was used for Gene Ontology (GO) and pathway enrichment analysis. After that, animal experiments were then performed to further validate the results of systemic pharmacology and chemoinformatics.<\/jats:p>\n               <jats:p>Results: Three major networks were constructed: (1) CHD genes\u2019 protein\u2013protein interaction (PPI) network; (2) SMY\u2013CHD PPI network; (3) SMY known target\u2013CHD PPI network. The other networks are minor networks generated by analyzing the three major networks. Experimental results showed that compared with the model group, the Shengmai injection (SMI) can reduce the myocardial injury score and the activities of serum aspartate aminoconvertase (AST), CK and lactate dehydrogenase (LDH) in rats (P&amp;lt;0.05), and reduce serum lipid peroxide (LPO) content and increase serum superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in myocardial infarction rats (P&amp;lt;0.05). SMI can also decrease the expression of MMP-9 mRNA and increase that of TIMP-1 mRNA (P&amp;lt;0.01).<\/jats:p>\n               <jats:p>Conclusion: SMY may regulate the signaling pathways (such as PPAR, FoxO, VEGF signaling), biological processes (such as angiogenesis, blood pressure formation, inflammatory response) and targets (such as AKT1, EGFR, MAPK1) so as to play a therapeutic role in CHD.<\/jats:p>","DOI":"10.1042\/bsr20200286","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T14:00:43Z","timestamp":1590069643000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Exploring the mechanism of Shengmai Yin for coronary heart disease based on systematic pharmacology and chemoinformatics"],"prefix":"10.1042","volume":"40","author":[{"given":"Yan","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China"},{"name":"Graduate College, Hunan Normal University, Changsha, Hunan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"He","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, People\u2019s Hospital of Ningxiang City, Ningxiang 410600, Hunan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Graduate College, University of South China, Hengyang, Hunan Province, China"},{"name":"Department of Cardiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Xiang","sequence":"additional","affiliation":[{"name":"Graduate College, Guilin Medical University, Guilin, Guangxi Province, China"},{"name":"Department of Rheumatology, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyong","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Guangdong General Hospital, Shantou University Medical College, Shantou, Guangdong, China"},{"name":"Graduate College, Shantou University Medical College, Shantou, Guangdong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4162-9537","authenticated-orcid":false,"given":"Shiwei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2020,6,10]]},"reference":[{"key":"2021111620135623400_B1","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.amjmed.2014.04.015","article-title":"The epidemic of the 20(th) century: coronary heart disease","volume":"127","author":"Dalen","year":"2014","journal-title":"Am. 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