{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T03:30:59Z","timestamp":1764646259090,"version":"3.41.2"},"reference-count":20,"publisher":"Portland Press Ltd.","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background: It has been reported that uterine fibroids (UFs) may increase the risk of endometrial carcinoma (EC) with the underlying mechanism largely unknown. Here, we explore whether UF could be an influential factor for EC.<\/jats:p>\n               <jats:p>Methods: We have collected and analyzed clinical data from 4537 Chinese patients to study the co-incidence of UF and EC. Then, a large-scale literature-based data mining was conducted to identify genes implicated as UF downstream regulating targets and EC upstream regulators. In addition, a meta-analysis has been conducted for each of the EC-specific genes, using six independent UF expression datasets. The meta-analysis results, together with literature-based pathway analysis, were used to explore the potential explanation of the clinical data.<\/jats:p>\n               <jats:p>Results: Our results showed that the incidence rate of EC in the case of UF was 50.53% lower than without UF, which suggested a protective role of UF in EC patients. The meta-analysis identified three significantly overexpressed genes (HTRA3, HOPX, and PCNA) in the case of UF, which were implicated as EC inhibitors in the pathway analysis. Multiple linear regression (MLR) analysis showed that, compared with UF, aging might be a stronger influential factor for EC.<\/jats:p>\n               <jats:p>Conclusion: Among women with gynecological diseases, UFs may play a protecting role against EC in the Chinese population.<\/jats:p>","DOI":"10.1042\/bsr20200350","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T10:39:57Z","timestamp":1593599997000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Uterine fibroids may play a protecting role against endometrial carcinoma in Chinese women with gynecological diseases"],"prefix":"10.1042","volume":"40","author":[{"given":"Li","family":"Qiao","sequence":"first","affiliation":[{"name":"Intensive Care Unit (ICU), The Second People\u2019s Hospital of Lianyungang, Lianyungang, Jiangsu 222000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Tongling People\u2019s Hospital, Tongling, Anhui Province 244000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, The Second People\u2019s Hospital of Lianyungang, Lianyungang, Jiangsu Province 222000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8007-8630","authenticated-orcid":false,"given":"Yajuan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Intensive Care Unit (ICU), The Second People\u2019s Hospital of Lianyungang, Lianyungang, Jiangsu 222000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbao","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, First Hospital\/First Clinical Medical College of Shanxi Medical University, Taiyuan 030001, China"},{"name":"School of Systems Biology, George Mason University (GMU), Fairfax, VA 22030, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2020,7,10]]},"reference":[{"key":"2021111620194724200_B1","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1177\/1933719117725827","article-title":"Literature review on the role of uterine fibroids in endometrial function","volume":"25","author":"Ikhena","year":"2018","journal-title":"Reprod. Sci."},{"key":"2021111620194724200_B2","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.ygyno.2014.05.018","article-title":"Endometrial cancer: a review and current management strategies: part I","volume":"134","author":"Burke","year":"2014","journal-title":"Gynecol. Oncol."},{"key":"2021111620194724200_B3","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1002\/ijc.25516","article-title":"Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008","volume":"127","author":"Ferlay","year":"2010","journal-title":"Int. J. Cancer"},{"key":"2021111620194724200_B4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/ijc.25516","article-title":"Cancer statistics, 2013","volume":"63","author":"Siegel","year":"2013","journal-title":"CA Cancer J. Clin."},{"key":"2021111620194724200_B5","first-page":"180","article-title":"Endometrial polyps: prevalence, detection, and malignant potential in women with abnormal uterine bleeding","volume":"21","author":"Anastasiadis","year":"2000","journal-title":"Eur. J. Gynaecol. Oncol."},{"key":"2021111620194724200_B6","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1007\/s10552-016-0728-3","article-title":"History of uterine leiomyoma and risk of endometrial cancer in black women","volume":"27","author":"Wise","year":"2016","journal-title":"Cancer Causes Control"},{"key":"2021111620194724200_B7","first-page":"33","article-title":"The genomics and genetics of endometrial cancer","volume":"2012","author":"O\u2019Hara","year":"2012","journal-title":"Adv. Genomics Genet."},{"key":"2021111620194724200_B8","first-page":"181","article-title":"The genetic bases of uterine fibroids; a review","volume":"12","author":"Medikare","year":"2011","journal-title":"J. Reprod. Infertil."},{"key":"2021111620194724200_B9","first-page":"198","article-title":"The analysis and classification of chromosomes. I. Application of the Bayes\u2019 theorem","volume":"10","author":"Jagielski","year":"1978","journal-title":"Mater. Med. Pol."},{"key":"2021111620194724200_B10","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1002\/jrsm.12","article-title":"A basic introduction to fixed-effect and random-effects models for meta-analysis","volume":"1","author":"Borenstein","year":"2010","journal-title":"Res. Synth. Methods"},{"key":"2021111620194724200_B11","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.1093\/bioinformatics\/btg290","article-title":"Pathway studio\u2013the analysis and navigation of molecular networks","volume":"19","author":"Nikitin","year":"2003","journal-title":"Bioinformatics"},{"key":"2021111620194724200_B12","doi-asserted-by":"publisher","first-page":"7596","DOI":"10.1158\/0008-5472.CAN-04-1627","article-title":"RNA interference targeting transforming growth factor-beta enhances NKG2D-mediated antiglioma immune response, inhibits glioma cell migration and invasiveness, and abrogates tumorigenicity in vivo","volume":"64","author":"Friese","year":"2004","journal-title":"Cancer Res."},{"key":"2021111620194724200_B13","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1006\/gyno.1994.1092","article-title":"Expression of EGFR, HER-2\/neu, P53, and PCNA in endometrioid, serous papillary, and clear cell endometrial adenocarcinomas","volume":"53","author":"Khalifa","year":"1994","journal-title":"Gynecol. Oncol."},{"key":"2021111620194724200_B14","doi-asserted-by":"publisher","first-page":"2918","DOI":"10.1016\/j.bbrc.2018.08.070","article-title":"Hypoxia is involved in the reduction of HtrA3 in patients with endometrial hyperplasia and cancer","volume":"503","author":"Lv","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021111620194724200_B15","doi-asserted-by":"publisher","first-page":"14053","DOI":"10.1038\/ncomms14053","article-title":"HOPX hypermethylation promotes metastasis via activating SNAIL transcription in nasopharyngeal carcinoma","volume":"8","author":"Ren","year":"2017","journal-title":"Nat. Commun."},{"key":"2021111620194724200_B16","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/S0039-128X(00)00194-X","article-title":"Progesterone receptor modulators and progesterone antagonists in women\u2019s health","volume":"65","author":"Spitz","year":"2000","journal-title":"Steroids"},{"key":"2021111620194724200_B17","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.fertnstert.2012.09.011","article-title":"Differential expression of G-protein-coupled estrogen receptor-30 in human myometrial and uterine leiomyoma smooth muscle","volume":"99","author":"Tian","year":"2013","journal-title":"Fertil. Steril."},{"key":"2021111620194724200_B18","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1530\/REP-06-0326","article-title":"Estrogen receptor alpha mediates estrogen-inducible abnormalities in the developing penis","volume":"133","author":"Goyal","year":"2007","journal-title":"Reproduction"},{"key":"2021111620194724200_B19","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.1359\/JBMR.050813","article-title":"Histone deacetylase inhibitors promote osteoblast maturation","volume":"20","author":"Schroeder","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"2021111620194724200_B20","article-title":"Uterine fibroids fact sheet","author":"U.S. Department of Health and Human Services","year":"2019","journal-title":"Office on Women\u2019s Health"}],"container-title":["Bioscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20200350\/887969\/bsr-2020-0350.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20200350\/887969\/bsr-2020-0350.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T20:51:23Z","timestamp":1637095883000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/bioscirep\/article\/40\/7\/BSR20200350\/225652\/Uterine-fibroids-may-play-a-protecting-role"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7,31]]}},"URL":"https:\/\/doi.org\/10.1042\/bsr20200350","relation":{},"ISSN":["0144-8463","1573-4935"],"issn-type":[{"type":"print","value":"0144-8463"},{"type":"electronic","value":"1573-4935"}],"subject":[],"published-other":{"date-parts":[[2020,7]]},"published":{"date-parts":[[2020,7]]},"article-number":"BSR20200350"}}