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The HF models were established by inducing ischemia myocardial infarction (MI) through ligation of the left anterior descending (LAD) artery in Sprague\u2013Dawley (SD) rats. Endostatin level in serum was increased in MI rats. The decrease in cardiac function and hemodynamics in MI rats were enhanced by endostatin overexpression. Endostatin overexpression inhibited the increase in collagen I, collagen III, \u03b1-smooth muscle actin (\u03b1-SMA), connective tissue growth factor (CTGF), matrix metalloproteinase (MMP)-2 and MMP9 in the hearts of MI rats. MI-induced cardiac hypertrophy was reduced by endostatin overexpression. The increased levels of malondialdehyde (MDA), superoxide anions, the promoted NAD(P)H oxidase (Nox) activity, and the reduced superoxide dismutase (SOD) activity in MI rats were reversed by endostatin overexpression. Nox4 overexpression inhibited the cardiac protective effects of endostatin. These results demonstrated that endostatin improved cardiac dysfunction and hemodynamics, and attenuated cardiac fibrosis and hypertrophy via inhibiting oxidative stress in MI-induced HF rats.<\/jats:p>","DOI":"10.1042\/bsr20200787","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T10:56:12Z","timestamp":1595242572000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Endostatin attenuates heart failure via inhibiting reactive oxygen species in myocardial infarction rats"],"prefix":"10.1042","volume":"41","author":[{"given":"Xuguang","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, China"},{"name":"Department of Cardiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6901-824X","authenticated-orcid":false,"given":"Tingbo","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liusha","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2021,6,29]]},"reference":[{"key":"2021111620215903300_B1","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.3390\/ijerph7041807","article-title":"The heart failure epidemic","volume":"7","author":"Roger","year":"2010","journal-title":"Int. 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