{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:12:27Z","timestamp":1791000747804,"version":"4.1.0"},"reference-count":33,"publisher":"Portland Press Ltd.","issue":"7","license":[{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background: Ovarian cancer (OC) is one lethal gynecologic cancer, with a 5-year survival rate approximately 47% and localized stage diagnosis of 15%. Circular RNAs are promising biomarkers for malignancies.<\/jats:p>\n               <jats:p>Methods: CiRS-7 expression was confirmed in 40 paired OC and normal adjacent tissues from 40 OC patients with different TNM stages, lymph node metastasis status and overall survival rate, also 5 different OC cell lines by qRT-PCR. Effects of ciRS-7 silence on OC cell phenotypes were determined in OC cells and Xenograft mouse model. StarBase was used to predict binding sites between ciRS-7 and micRNAs. Pearson correlation analysis and RNA-immunoprecipitation assay were used to determine the association between genes. Point mutation and rescue experiments were applied for molecular mechanism investigation.<\/jats:p>\n               <jats:p>Results: CiRS-7 expression was significantly higher in OC cells and tissues, which was significantly associated with the TNM stages, lymph node metastasis status and overall survival rate in OC patients. CiRS-7 silence inhibited OC cell growth and metastasis. CiRS-7 sponged miR-641 to up-regulate ZEB1 and MDM2 expression in OC development.<\/jats:p>\n               <jats:p>Conclusion: CiRS-7 serves as a competing endogenous RNA of miR-641 that promoted cell growth and metastasis in OC, via regulating ZEB1 and MDM2-mediated EMT. High ciRS-7 expression was a poor prognosis of TNM stages, lymph node metastasis status and overall survival rate in OC patients. Targeting ciRS-7\/miR-641\/ZEB1 or ciRS-7\/miR-641\/MDM2 axis may be a novel diagnostic, prognostic and therapeutic strategy for OC.<\/jats:p>","DOI":"10.1042\/bsr20200825","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T14:28:08Z","timestamp":1594823288000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Circular RNA S-7 promotes ovarian cancer EMT via sponging miR-641 to up-regulate ZEB1 and <i>MDM2<\/i>"],"prefix":"10.1042","volume":"40","author":[{"given":"Fenghua","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, the Third Affiliated Hospital of Soochow University, 185 Bureau Street, Changzhou 213003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, the Third Affiliated Hospital of Soochow University, 185 Bureau Street, Changzhou 213003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfeng","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, the Third Affiliated Hospital of Soochow University, 185 Bureau Street, Changzhou 213003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingting","family":"Jiang","sequence":"additional","affiliation":[{"name":"Changzhou Cancer Biomedical Treatment Center of Jiangsu Province, 185 Bureau Street, Changzhou 213003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9236-8288","authenticated-orcid":false,"given":"Changping","family":"Wu","sequence":"additional","affiliation":[{"name":"Changzhou Cancer Biomedical Treatment Center of Jiangsu Province, 185 Bureau Street, Changzhou 213003, China"},{"name":"Department of Oncology, the Third Affiliated Hospital of Soochow University, 185 Bureau Street, Changzhou 213003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2020,7,24]]},"reference":[{"key":"2021111620213850000_B1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3322\/canjclin.51.1.15","article-title":"Cancer statistics, 2001","volume":"51","author":"Greenlee","year":"2001","journal-title":"CA Cancer J. 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