{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:02:17Z","timestamp":1789506137507,"version":"build-2803163510"},"reference-count":60,"publisher":"Portland Press Ltd.","issue":"7","license":[{"start":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T00:00:00Z","timestamp":1594166400000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) in hormone metabolism pathways might cause metabolic disturbances and contribute to the development of polycystic ovary syndrome (PCOS) and ovarian cancer, but the published studies were inconsistent. The aim of the present study was to evaluate the MTHFR C677T (rs1801133) and A1298C (rs1801131) gene polymorphisms in the risk of PCOS and ovarian cancer by meta-analysis. A comprehensive electronic search was conducted in databases for studies published from 1995 to 2020. The pooled ORs were calculated by Revman 5.2 software. Twenty-nine articles including 45 case\u2013control studies were included. We found that MTHFR C677T polymorphisms were correlated with elevated PCOS risk (TT vs. CT+CC: OR = 1.41, 95%CI = 1.20\u20131.67; TT+CT vs. CC: OR = 1.54, 95%CI = 1.07\u20132.22; CT vs. CC+TT: OR = 1.18, 95%CI 1.04\u20131.33; TT vs. CC: OR = 1.47, 95%CI = 1.03\u20132.11; T vs. C: OR = 1.25, 95%CI = 1.06\u20131.47), which were more obvious in Middle Eastern subgroup. MTHFR A1298C polymorphisms were also associated with overall PCOS susceptibility (CC vs. AC+AA: OR = 2.55, 95% CI = 1.61\u20134.03; CC+AC vs. AA: OR = 1.84, 95%CI = 1.04\u20133.28; CC vs. AA: OR = 2.66, 95%CI = 1.68\u20134.22; C vs. A: OR = 1.67, 95%CI = 1.03\u20132.71), which were mainly reflected in Asian subjects. For ovarian cancer, MTHFR C677T polymorphisms were only related with elevated ovarian cancer risk in Asian population, while no significant association was found for A1298C polymorphisms. This meta-analysis suggested that MTHFR C677T and MTHFR A1298C polymorphisms were correlated with elevated PCOS risk. MTHFR C667T only posed a higher risk for ovarian cancer in Asians instead of other populations, while MTHFR A1298C polymorphisms were not related to ovarian cancer risk. Further studies are needed to validate the conclusion.<\/jats:p>","DOI":"10.1042\/bsr20200995","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T14:29:54Z","timestamp":1594218594000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Methylenetetrahydrofolate reductase gene polymorphisms in the risk of polycystic ovary syndrome and ovarian cancer"],"prefix":"10.1042","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0532-6328","authenticated-orcid":false,"given":"Ying","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ce","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kehui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2020,7,17]]},"reference":[{"key":"2021111620205477700_B1","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1056\/NEJM199509283331307","article-title":"Polycystic ovary syndrome","volume":"333","author":"Franks","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"2021111620205477700_B2","first-page":"19","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"81","author":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group","year":"2004","journal-title":"Hum. Reprod."},{"key":"2021111620205477700_B3","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1136\/heart.86.2.121","article-title":"Homocysteine: a novel risk factor for coronary heart disease in UK Indian Asians","volume":"86","author":"Chambers","year":"2001","journal-title":"Heart"},{"key":"2021111620205477700_B4","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.ajog.2004.04.045","article-title":"A practical approach to the diagnosis of polycystic ovary syndrome","volume":"191","author":"Chang","year":"2004","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2021111620205477700_B5","first-page":"109","article-title":"Metabolic syndrome in polycystic ovary syndrome","volume":"58","author":"Carmina","year":"2006","journal-title":"Minerva Ginecol."},{"key":"2021111620205477700_B6","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s12958-019-0509-4","article-title":"Polycystic ovary syndrome and mitochondrial dysfunction","volume":"17","author":"Zhang","year":"2019","journal-title":"Reproduct. Biol. Endocrinol."},{"key":"2021111620205477700_B7","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.steroids.2013.04.004","article-title":"Cancer risk and PCOS","volume":"78","author":"Dumesic","year":"2013","journal-title":"Steroids"},{"key":"2021111620205477700_B8","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1093\/humupd\/dmu012","article-title":"Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis","volume":"20","author":"Barry","year":"2014","journal-title":"Hum. Reprod. Update"},{"key":"2021111620205477700_B9","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1677\/ERC-08-0075","article-title":"Epithelial ovarian cancer: testing the \u2018androgens hypothesis\u2019","volume":"15","author":"Olsen","year":"2008","journal-title":"Endocr. Relat. Cancer"},{"key":"2021111620205477700_B10","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1002\/ijc.30441","article-title":"Long and irregular menstrual cycles, polycystic ovary syndrome, and ovarian cancer risk in a population-based case\u2013control study","volume":"140","author":"Harris","year":"2016","journal-title":"Int. J. Cancer"},{"key":"2021111620205477700_B11","doi-asserted-by":"publisher","first-page":"e3","DOI":"10.1017\/S1462399408000598","article-title":"Polycystic ovarian syndrome: pathophysiology, molecular aspects and clinical implications","volume":"10","author":"Diamanti-Kandarakis","year":"2008","journal-title":"Exp. Rev. Mol. Med."},{"key":"2021111620205477700_B12","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/nrendo.2010.217","article-title":"Polycystic ovary syndrome: etiology, pathogenesis and diagnosis","volume":"7","author":"Goodarzi","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"2021111620205477700_B13","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.diabres.2006.05.018","article-title":"MTHFR C677T and A1298C gene polymorphisms and hyperhomocysteinemia as risk factors of diabetic nephropathy in type 2 diabetes patients","volume":"75","author":"Mtiraoui","year":"2007","journal-title":"Diabetes Res. Clin. Pract."},{"key":"2021111620205477700_B14","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1089\/gtmb.2009.0046","article-title":"The analysis of the relationship between A1298C and C677T polymorphisms of the MTHFR gene with prostate cancer in Eskisehir population","volume":"13","author":"Muslumanoglu","year":"2009","journal-title":"Genetic Testing Mol. Biomarkers"},{"key":"2021111620205477700_B15","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/gim.2012.165","article-title":"ACMG Practice Guideline: lack of evidence for MTHFR polymorphism testing","volume":"15","author":"Hickey","year":"2013","journal-title":"Genet. Med."},{"key":"2021111620205477700_B16","doi-asserted-by":"publisher","first-page":"e57917","DOI":"10.1371\/journal.pone.0057917","article-title":"Geographical distribution of MTHFR C677T, A1298C and MTRR A66G gene polymorphisms in China: findings from 15357 adults of Han nationality","volume":"8","author":"Yang","year":"2013","journal-title":"PLoS ONE"},{"key":"2021111620205477700_B17","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1016\/S0026-0495(99)90250-0","article-title":"Plasminogen activator inhibitor activity: an independent risk factor for the high miscarriage rate during pregnancy in women with polycystic ovary syndrome","volume":"48","author":"Glueck","year":"1999","journal-title":"Metabolism"},{"key":"2021111620205477700_B18","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.ejogrb.2013.12.030","article-title":"Plasminogen activator inhibitor-1 4G\/5G and the MTHFR 677C\/T polymorphisms and susceptibility to polycystic ovary syndrome: a meta-analysis","volume":"175","author":"Lee","year":"2014","journal-title":"Eur. J. Obstetr. Gynecol. Reproduct. Biolol."},{"key":"2021111620205477700_B19","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.ejogrb.2013.10.001","article-title":"Association of methylenetetrahydrofolate reductase gene C677T polymorphism with polycystic ovary syndrome risk: a systematic review and meta-analysis update","volume":"172","author":"Fu","year":"2014","journal-title":"Eur. J. Obstet. Gynecol. Reproduct. Biolol."},{"key":"2021111620205477700_B20","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.31557\/APJCP.2019.20.9.2569","article-title":"Association of MTHFR 677C&gt;T Polymorphism with Susceptibility to Ovarian and Cervical Cancers: A Systematic Review and Meta-Analysis","volume":"20","author":"Karimi-Zarchi","year":"2019","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"2021111620205477700_B21","doi-asserted-by":"publisher","first-page":"227","DOI":"10.2147\/OTT.S121472","article-title":"MTHFR C677T polymorphism and breast, ovarian cancer risk: a meta-analysis of 19,260 patients and 26,364 controls","volume":"10","author":"He","year":"2017","journal-title":"OncoTargets Ther."},{"key":"2021111620205477700_B22","doi-asserted-by":"crossref","first-page":"e0151510","DOI":"10.1371\/journal.pone.0151510","article-title":"Is MTHFR 677 C&gt;T Polymorphism Clinically Important in Polycystic Ovarian Syndrome (PCOS)? A Case-Control Study, Meta-Analysis and Trial Sequential Analysis","volume":"11","author":"Carlus","year":"2016","journal-title":"PLoS ONE."},{"key":"2021111620205477700_B23","first-page":"400","article-title":"Association of methylenetetrahydrofolate reductase gene polymorphisms with polycystic ovary syndrome","volume":"32","author":"Qi","year":"2015","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"},{"key":"2021111620205477700_B24","doi-asserted-by":"publisher","DOI":"10.4238\/gmr15048570","article-title":"Role of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in polycystic ovary syndrome risk","volume":"15","author":"Wu","year":"2016","journal-title":"Genetic and Mol. Res."},{"key":"2021111620205477700_B25","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.ejogrb.2009.04.013","article-title":"Association between a single nucleotide polymorphism in MTHFR gene and polycystic ovary syndrome","volume":"145","author":"Choi","year":"2009","journal-title":"Eur. J. Obstet. Gynecol. Reproduct. Biol."},{"key":"2021111620205477700_B26","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1111\/aji.12002","article-title":"Plasminogen activator inhibitor 1 and methylenetetrahydrofolate reductase gene mutations in iranian women with polycystic ovary syndrome","volume":"68","author":"Idali","year":"2012","journal-title":"Am. J. Reprod. Immunol."},{"key":"2021111620205477700_B27","doi-asserted-by":"publisher","first-page":"52","DOI":"10.4103\/0974-1208.97802","article-title":"MTHFR C677T polymorphism is associated with hyperlipidemia in women with polycystic ovary syndrome","volume":"5","author":"Jain","year":"2012","journal-title":"J. Human Reproduct. Sci."},{"key":"2021111620205477700_B28","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s12020-010-9370-0","article-title":"Methylenetetrahydrofolate reductase C677T gene polymorphism in Turkish patients with polycystic ovary syndrome","volume":"38","author":"Karadeniz","year":"2010","journal-title":"Endocrine"},{"key":"2021111620205477700_B29","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1210\/jc.2002-021142","article-title":"Homocysteine levels and C677T polymorphism of methylenetetrahydrofolate reductase in women with polycystic ovary syndrome","volume":"88","author":"Orio","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2021111620205477700_B30","doi-asserted-by":"publisher","first-page":"246","DOI":"10.17772\/gp\/61751","article-title":"Is there an association between the development of metabolic syndrome in PCOS patients and the C677T MTHFR gene polymorphism?","volume":"87","author":"Ozegowska","year":"2016","journal-title":"Ginekol. Pol."},{"key":"2021111620205477700_B31","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1080\/14647270600950157","article-title":"Polycystic ovary syndrome and the single nucleotide polymorphisms of methylenetetrahydrofolate reductase: a pilot observational study","volume":"10","author":"Palep-Singh","year":"2007","journal-title":"Human Fertility (Camb)"},{"key":"2021111620205477700_B32","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/j.1447-0756.2001.tb01241.x","article-title":"Plasma homocysteine, fasting insulin, and androgen patterns among women with polycystic ovaries and infertility","volume":"27","author":"Sills","year":"2001","journal-title":"J. Obstetetrics Gynaecologic Res."},{"key":"2021111620205477700_B33","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1093\/humrep\/17.2.314","article-title":"Polycystic ovarian syndrome and thrombophilia","volume":"1","author":"Tsanadis","year":"2002","journal-title":"Hum. Reprod."},{"key":"2021111620205477700_B34","first-page":"8532","article-title":"Role of methylenetetrahydrofolate reductase genetic polymorphisms in polycystic ovary syndrome risk","volume":"9","author":"Geng","year":"2016","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"2021111620205477700_B35","first-page":"3831","article-title":"Study on the correlation between methylenetetrahydrofolate reductase gene polymorphisms and polycystic ovary syndrome","volume":"30","author":"Jiang","year":"2015","journal-title":"Maternal & Child Health Care of China"},{"key":"2021111620205477700_B36","doi-asserted-by":"publisher","first-page":"504","DOI":"10.3389\/fendo.2018.00504","article-title":"Variant Alleles of the ESR1, PPARG, HMGA2, and MTHFR genes are associated with polycystic ovary syndrome risk in a Chinese population: A case-control study","volume":"9","author":"Jiao","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"2021111620205477700_B37","first-page":"217","article-title":"The study of 5,10- methylenetetrahydrofolate reductase variation (MTHFR C677T) in infertile females with polycystic ovarian syndrome","volume":"30","author":"Lee","year":"2003","journal-title":"Korean J. Fert. Ster."},{"key":"2021111620205477700_B38","first-page":"229","article-title":"Prevalence of methylenetetrahydrofolate reductase C677T polymorphism in women with polycystic ovary syndrome in southeast of Iran","volume":"8","author":"Naghavi","year":"2015","journal-title":"J. Med. Life"},{"key":"2021111620205477700_B39","first-page":"141","article-title":"Methylenetetrahydrofolate reductase A1298C and C677T polymorphisms and adverse pregnancy outcome in women with PCOS","volume":"37","author":"Szafarowska","year":"2016","journal-title":"Neuro Endocrinol. Lett."},{"key":"2021111620205477700_B40","doi-asserted-by":"publisher","first-page":"569","DOI":"10.7314\/APJCP.2012.13.2.569","article-title":"Methylenetetrahydrofolate reductase gene polymorphisms as predictive and prognostic biomarkers in ovarian cancer risk","volume":"13","author":"Gao","year":"2012","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"2021111620205477700_B41","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s10549-006-9417-3","article-title":"Methylenetetrahydrofolate reductase polymorphisms modify BRCA1-associated breast and ovarian cancer risks","volume":"104","author":"Jakubowska","year":"2007","journal-title":"Breast Cancer Res. Treat."},{"key":"2021111620205477700_B42","first-page":"459","article-title":"Association between MTHFR C677T polymorphism and folate, vitamin B12, homocysteine, and DNA fragmentation in patients with ovarian cancer","volume":"41","author":"Ozkilic","year":"2016","journal-title":"Turk Biyokimya Dergisi."},{"key":"2021111620205477700_B43","doi-asserted-by":"publisher","first-page":"5553","DOI":"10.1007\/s11033-011-1359-0","article-title":"Folate and choline metabolism gene variants in relation to ovarian cancer risk in the Polish population","volume":"39","author":"Pawlik","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"2021111620205477700_B44","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1159\/000331131","article-title":"Association of the functional polymorphism C677T in the methylenetetrahydrofolate reductase gene with colorectal, thyroid, breast, ovarian, and cervical cancers","volume":"34","author":"Prasad","year":"2011","journal-title":"Onkologie"},{"key":"2021111620205477700_B45","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.ygyno.2010.08.007","article-title":"MTHFR polymorphisms in relation to ovarian cancer risk","volume":"119","author":"Terry","year":"2010","journal-title":"Gynecol. Oncol."},{"key":"2021111620205477700_B46","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1038\/ejcn.2011.99","article-title":"Australian cancer study (Ovarian Cancer), Australian ovarian cancer study group. Folate and related micronutrients, folate-metabolising genes and risk of ovarian cancer","volume":"65","author":"Webb","year":"2011","journal-title":"Eur. J. Clin. Nutr."},{"key":"2021111620205477700_B47","first-page":"811","article-title":"Association between genetic polymorphisms of methylenetetrahydrofolate reductase C677T and susceptibility to ovarian cancer","volume":"16","author":"Wu","year":"2007","journal-title":"Prog. Obstet. Gynecol."},{"key":"2021111620205477700_B48","doi-asserted-by":"publisher","first-page":"4009","DOI":"10.3390\/ijms13044009","article-title":"Folate intake and methylenetetrahydrofolate reductase gene polymorphisms as predictive and prognostic biomarkers for ovarian cancer risk","volume":"13","author":"Zhang","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"2021111620205477700_B49","first-page":"4761","article-title":"Folate. MTHFR C677T and A1298C polymorhpisms with the relationship with ovarian cancer risk among Chinese females","volume":"6","author":"Song","year":"2012","journal-title":"African J. Microbiologic Res."},{"key":"2021111620205477700_B50","doi-asserted-by":"publisher","first-page":"2641","DOI":"10.1093\/humrep\/12.12.2641","article-title":"The genetic basis of polycystic ovary syndrome","volume":"12","author":"Franks","year":"1997","journal-title":"Hum. Reprod."},{"key":"2021111620205477700_B51","doi-asserted-by":"publisher","first-page":"27s","DOI":"10.1016\/S0002-9343(99)80056-4","article-title":"Obesity, lipids, cardiovascular risk, and androgen excess","volume":"98","author":"Wild","year":"1995","journal-title":"Am. J. Med."},{"key":"2021111620205477700_B52","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1590\/S0004-27302007000600012","article-title":"Metabolic syndrome in women with polycystic ovary syndrome: prevalence, characteristics and predictors","volume":"51","author":"Marcondes","year":"2007","journal-title":"Arquivos Brasileiros De Endocrinologia Metabologia"},{"key":"2021111620205477700_B53","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/S0140-6736(07)61345-2","article-title":"Polycystic ovary syndrome","volume":"370","author":"Norman","year":"2007","journal-title":"Lancet"},{"key":"2021111620205477700_B54","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1093\/humupd\/dms030","article-title":"Overweight, obesity and central obesity in women with polycystic ovary syndrome: a systematic review and meta-analysis","volume":"18","author":"Lim","year":"2012","journal-title":"Hum. Reprod. Update"},{"key":"2021111620205477700_B55","doi-asserted-by":"publisher","first-page":"52553","DOI":"10.18632\/oncotarget.9651","article-title":"Targeting folate receptor alpha for cancer treatment","volume":"7","author":"Cheung","year":"2016","journal-title":"Oncotarget"},{"key":"2021111620205477700_B56","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.1111\/jog.14132","article-title":"Phenotype and genotype of polycystic ovary syndrome in Asia: Ethnic differences","volume":"45","author":"Kim","year":"2019","journal-title":"J. Obstet. Gynaecologic Res."},{"key":"2021111620205477700_B57","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0140-6736(08)60167-1","article-title":"Ovarian cancer and oral contraceptives: collaborative reanalysis of data from 45 epidemiological studies including 23,257 women with ovarian cancer and 87,303 controls","volume":"371","author":"Beral","year":"2008","journal-title":"Lancet"},{"key":"2021111620205477700_B58","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1634\/theoncologist.2014-0311","article-title":"A nationwide population-based retrospective cohort study of the risk of uterine, ovarian and breast cancer in women with polycystic ovary syndrome","volume":"20","author":"Shen","year":"2015","journal-title":"Oncologist"},{"key":"2021111620205477700_B59","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/0029-7844(96)00226-8","article-title":"Epithelial ovarian cancer risk among women with polycystic ovary syndrome","volume":"88","author":"Schildkraut","year":"1996","journal-title":"Obstet. Gynecol."},{"key":"2021111620205477700_B60","doi-asserted-by":"publisher","first-page":"166","DOI":"10.4103\/0976-9668.184704","article-title":"Study on the proportion and determinants of polycystic ovarian syndrome among health sciences students in South India","volume":"7","author":"Joseph","year":"2016","journal-title":"J. Nat. Sci. Biol. Med."}],"container-title":["Bioscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20200995\/888340\/bsr-2020-0995.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20200995\/888340\/bsr-2020-0995.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T20:51:52Z","timestamp":1637095912000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/bioscirep\/article\/40\/7\/BSR20200995\/225735\/Methylenetetrahydrofolate-reductase-gene"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":60,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7,31]]}},"URL":"https:\/\/doi.org\/10.1042\/bsr20200995","relation":{},"ISSN":["0144-8463","1573-4935"],"issn-type":[{"value":"0144-8463","type":"print"},{"value":"1573-4935","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,7]]},"published":{"date-parts":[[2020,7]]},"article-number":"BSR20200995"}}