{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:02:07Z","timestamp":1790758927811,"version":"4.1.0"},"reference-count":40,"publisher":"Portland Press Ltd.","issue":"9","license":[{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Transforming growth factor-\u03b21 (TGF-\u03b21) is involved in human cancer development and progression. Nonetheless, the role of TGF-\u03b21 as regards peritoneal metastasis of gastric cancer has not been completely characterized. In the present study, we investigated the exact role of TGF-\u03b21 on peritoneal metastasis of gastric cancer. The results indicated that human peritoneal mesothelial cells (HPMCs) exposed to TGF-\u03b21 or serum-free conditional medium (SF-CM) of SGC7901 that produced a large amount of TGF-\u03b21 became exfoliated, apoptosis and exhibited signs of injury, and the tumor-mesothelial cell adhesion significantly increased. Connective tissue growth factor (CTGF) expression was also increased when HPMCs were exposed to TGF-\u03b21 or SF-CM of SGC7901. However, these effects were significantly decreased when HPMCs were exposed to SF-CM of SGC7901-TGF\u03b2S, a TGF-\u03b21 knockdown stable cell line. Animal studies revealed that nude mice injected with SGC7901-TGF\u03b2S cells featured a smaller number of peritoneal seeding nodules and lower expression of CTGF in ascites than the control cell lines. These findings suggest that TGF-\u03b21 promotes peritoneal metastasis of gastric cancer and induces CTGF expression. Therefore, blockage of TGF-\u03b21 or TGF-\u03b21 signaling pathway might prevent and treat peritoneal metastasis of gastric cancer.<\/jats:p>","DOI":"10.1042\/bsr20201501","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T10:38:38Z","timestamp":1599215918000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Transforming growth factor-\u03b21 induces connective tissue growth factor expression and promotes peritoneal metastasis of gastric cancer"],"prefix":"10.1042","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0399-8019","authenticated-orcid":false,"given":"Ling","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Rong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, China Medical University, Shenyang, Liaoning Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and General Surgery, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Mian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and General Surgery, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Ning","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and General Surgery, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Gang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and General Surgery, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2020,9,18]]},"reference":[{"key":"2021111620273280000_B1","doi-asserted-by":"publisher","first-page":"3405","DOI":"10.1111\/cas.14191","article-title":"Dissection of gastric cancer heterogeneity for precision oncology","volume":"110","author":"Ho","year":"2019","journal-title":"Cancer Sci."},{"key":"2021111620273280000_B2","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.suronc.2018.08.004","article-title":"Current challenges in gastric cancer surgery: European perspective","volume":"27","author":"Rawicz-Pruszy\u0144ski","year":"2018","journal-title":"Surg. 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