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Experiments were carried out in Sprague-Dawley rat treatment with ligation of left coronary artery to induce heart failure, and in CFs administration of Ang II to induce fibrosis. The level of miR-132 was increased in the heart of rats with MI-induced heart failure and the Ang II-treated CFs. In MI rats, left ventricle (LV) ejection fraction, fractional shortening, the maximum of the first differentiation of LV pressure (LV +dp\/dtmax) and decline (LV -dp\/dtmax) and LV systolic pressure (LVSP) were reduced, and LV end-systolic diameter (LVESD), LV end-diastolic diameter (LVEDD), LV volumes in systole (LVVS) and LV volumes in diastole (LVVD) were increased, which were reversed by miR-132 agomiR but deteriorated by miR-132 antagomiR. The expression levels of collagen I, collagen III, transforming growth factor-\u03b2 (TGF-\u03b2), and \u03b1-smooth muscle actin (\u03b1-SMA) were increased in the heart of rat with MI-induced heart failure and CFs administration of Ang II. These increases were inhibited by miR-132 agomiR but enhanced by miR-132 antagomiR treatment. MiR-132 inhibited PTEN expression, and attenuated PI3K\/Akt signal pathway in CFs. These results indicated that the up-regulation of miR-132 improved the cardiac dysfunction, attenuated cardiac fibrosis in heart failure via inhibiting PTEN expression, and attenuating PI3K\/Akt signal pathway. Up-regulation of miR-132 may be a strategy for the treatment of heart failure and cardiac fibrosis.<\/jats:p>","DOI":"10.1042\/bsr20201696","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T10:38:37Z","timestamp":1599215917000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["MicroRNA-132 attenuated cardiac fibrosis in myocardial infarction-induced heart failure rats"],"prefix":"10.1042","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1343-1187","authenticated-orcid":false,"given":"Guoyu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Taizhou People\u2019s Hospital, Taizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruzhu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Taizhou People\u2019s Hospital, Taizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongbao","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Taizhou People\u2019s Hospital, Taizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Taizhou People\u2019s Hospital, Taizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Taizhou People\u2019s Hospital, Taizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2020,9,16]]},"reference":[{"key":"2021111620274055000_B1","doi-asserted-by":"publisher","first-page":"H2181","DOI":"10.1152\/ajpheart.00554.2011","article-title":"Oxidative stress and heart failure","volume":"301","author":"Tsutsui","year":"2011","journal-title":"Am. 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