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The entry and infection strategy of SARS-CoV-2 in a host cell is raised by an amazing way of angiotensin-converting enzyme (ACE) 2 (ACE2) receptor recognition and imbalance of ACE\/ACE2 in various organs, especially in the lungs. Here it has been discussed the role of interferon and protease during the receptor recognition (begining of infection) and followed by the impact of cytokine and hypoxia in the context of the balance of ACE\/ACE2. It has also very concisely delineated the biochemistry and mechanism of ACE\/ACE2 balance in different stages of infection and its role in comorbidity.<\/jats:p>","DOI":"10.1042\/bsr20202014","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T11:56:44Z","timestamp":1610625404000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["ACE\/ACE2 balance might be instrumental to explain the certain comorbidities leading to severe COVID-19 cases"],"prefix":"10.1042","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9603-1415","authenticated-orcid":false,"given":"Sarbashri","family":"Bank","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Vidyasagar University, Medinipur, India"},{"name":"Cardiovascular disease section, Sinha Institute of Medical Science and Technology, Kolkata, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subrata Kumar","family":"De","sequence":"additional","affiliation":[{"name":"Department of Zoology, Vidyasagar University, Medinipur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biswabandhu","family":"Bankura","sequence":"additional","affiliation":[{"name":"Department of Zoology, University of Calcutta, Kolkata, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1354-1303","authenticated-orcid":false,"given":"Smarajit","family":"Maiti","sequence":"additional","affiliation":[{"name":"OIST, Biochemistry and Biotechnology, Medinipur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhusudan","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Zoology, University of Calcutta, Kolkata, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gausal","family":"A Khan","sequence":"additional","affiliation":[{"name":"Department of Physiology and Physiotherapy, CMNHS, Fiji School of Medicine, Fiji National University, Fiji"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2021,2,1]]},"reference":[{"key":"2021111620382467500_B1","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1038\/nature02145","article-title":"Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus","volume":"426","author":"Li","year":"2003","journal-title":"Nature"},{"key":"2021111620382467500_B2","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1165\/rcmb.2012-0339OC","article-title":"Innate immune response of human alveolar type II cells infected with severe acute respiratory syndrome-coronavirus","volume":"48","author":"Qian","year":"2013","journal-title":"Am. 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