{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T09:46:20Z","timestamp":1782899180715,"version":"3.54.5"},"reference-count":87,"publisher":"Portland Press Ltd.","issue":"1","license":[{"start":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T00:00:00Z","timestamp":1606435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: The liver and kidney inflammation due to bacterial infection is one of the most common pathological problems leading to tissue damage or disease. In many liver and kidney disorders, which represent serious global health burden with a high economic cost, oxidative stress-related inflammation and apoptosis are important pathogenic components, finally resulting in acute liver and\/or kidney failure. Erythropoietin and its analogues are well known to influence the interaction between apoptosis and inflammation in liver and kidney. Objective: The aim of the present study is to investigate and clarify the effect of Galaxaura oblongata (G. oblongata) red algae on lipopolysaccharides (LPS)-induced acute liver and kidney injury of mice with endotoxemia and associated molecular mechanism from inflammation, apoptosis and oxidative stress levels. Results: The current study cleared out that treatment of rats with the G. oblongata extract prior to LPS injection significantly lowered serum cytokines, including NF-\u03baB, MPO and LPO, and improved liver apoptosis through suppressing protein tyrosine kinase signaling pathway, and that may be due to antibacterial activity as well antioxidant capacity of G. oblongata extract. Conclusion: The present study was cleared out the possibility of administration of G. oblongata red algae as a multi products source for biotechnological, medical, nutraceutical and pharmaceutical applications due to highly antioxidant and anti-inflammatory capacities even although more investigations are required for separating, purifying and characterizing these bioactive compounds.<\/jats:p>","DOI":"10.1042\/bsr20202022","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T06:41:20Z","timestamp":1606459280000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Red algae natural products for prevention of lipopolysaccharides (LPS)-induced liver and kidney inflammation and injuries"],"prefix":"10.1042","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5560-0674","authenticated-orcid":false,"given":"Asmaa","family":"Nabil-Adam","sequence":"first","affiliation":[{"name":"Marine Biotechnology and Natural Products Laboratory, National Institute of Oceanography and Fisheries, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed\u00a0A.","family":"Shreadah","sequence":"additional","affiliation":[{"name":"Marine Biotechnology and Natural Products Laboratory, National Institute of Oceanography and Fisheries, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2021,1,15]]},"reference":[{"key":"2021111620340530600_B1","doi-asserted-by":"publisher","first-page":"316","DOI":"10.3389\/fmed.2018.00316","article-title":"Inflammation-Nature's Way to Efficiently Respond to All Types of Challenges: Implications for Understanding and Managing \u201cthe Epidemic\u201d of Chronic Diseases","volume":"5","author":"Bennett","year":"2018","journal-title":"Front. Med."},{"key":"2021111620340530600_B2","doi-asserted-by":"publisher","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2018","journal-title":"Oncotarget"},{"key":"2021111620340530600_B3","doi-asserted-by":"publisher","first-page":"586","DOI":"10.3389\/fimmu.2018.00586","article-title":"Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines","volume":"9","author":"Rea I","year":"2018","journal-title":"Front. Immunol."},{"key":"2021111620340530600_B4","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/j.procbio.2016.04.020","article-title":"Algae's sulfated polysaccharides modifications: Potential use of microbial enzymes","volume":"51","author":"Gurpilhares","year":"2016","journal-title":"Process Biochem."},{"key":"2021111620340530600_B5","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1007\/s10068-018-0323-3","article-title":"Phytochemical and pharmacological screening of Sargassium vulgare from Suez Canal, Egypt","volume":"27","author":"Shreadah","year":"2018","journal-title":"Food Sci. Biotechnol."},{"key":"2021111620340530600_B6","doi-asserted-by":"publisher","first-page":"964","DOI":"10.2174\/1389201020666190619092502","article-title":"Pesudomance sp. Bacteria Associated with Marine Sponge as a Promising and Sustainable Source of Bioactive Molecules","volume":"20","author":"Nabil-Adam","year":"2020","journal-title":"Curr. Pharm. Biotechnol."},{"key":"2021111620340530600_B7","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.3390\/molecules25041004","article-title":"Potential Use of Marine Seaweeds as Prebiotics: A Review","volume":"25","author":"Lopez-Santamarina","year":"2020","journal-title":"Molecules"},{"key":"2021111620340530600_B8","first-page":"7","article-title":"Marine Seaweed Polysaccharides-Based Engineered Cues for the Modern Biomedical Sector","volume":"18","author":"Bilal","year":"2020","journal-title":"Mar. Drugs 2020"},{"key":"2021111620340530600_B9","first-page":"1","article-title":"Environmental Assessment on the Aqaba Gulf Coastal waters","volume":"33","author":"Abdel-Halim","year":"2007","journal-title":"Egypt. Egyptian J. Aqu.Res."},{"key":"2021111620340530600_B10","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.4236\/jep.2016.710121","article-title":"Environmental studies on the Aqaba Gulf coastal waters during 2011-2013","volume":"7","author":"Abdel-Halim","year":"2016","journal-title":"J. Environ. Protection"},{"key":"2021111620340530600_B11","first-page":"517","article-title":"Environmental Conditions of the Suez Gulf and the Red Sea Coastal Waters, Egypt","volume-title":"Proceedings of the 8thInternational Conference on the Mediterranean Coastal Environment. MEDCOAST 2007","author":"Abo-el-Khair","year":"2007"},{"key":"2021111620340530600_B12","first-page":"20","article-title":"Environmental Impact Assessment of Northern Red Sea Regions during 2005 \u2013 2007","volume":"34","author":"Abo-El khair","year":"2008","journal-title":"Egyptian J. Aqu. Res."},{"key":"2021111620340530600_B13","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.4236\/jep.2016.711126","article-title":"Assessment of the hydrochemical characteristics for the coastal waters of the Suez Gulf during 2011-2013","volume":"7","author":"Abo-El-Khair","year":"2016","journal-title":"J. Environ. Protection"},{"key":"2021111620340530600_B14","first-page":"257","article-title":"Speciation of Fe, Mn and Zn in Surficial Sediments from the Egyptian Red Sea Coasts","volume":"22","author":"Masoud","year":"2010","journal-title":"Chem. Speciation Biodiversity"},{"key":"2021111620340530600_B15","first-page":"44","article-title":"Assessment of Heavy Metals Contamination in Surface Sediments of the Egyptian Red Sea Coasts","volume":"6","author":"Masoud","year":"2012","journal-title":"Aust. J. Basic Appl. Sci."},{"key":"2021111620340530600_B16","first-page":"33","article-title":"Alkyltin and alkayllead compounds in coastal water of Suez Gulf","volume":"36","author":"Said","year":"2010","journal-title":"Egypt. Egyptian J. Aqu. Res."},{"key":"2021111620340530600_B17","doi-asserted-by":"publisher","first-page":"e0169116","DOI":"10.1371\/journal.pone.0169116","article-title":"Production of Secondary Metabolites in Extreme Environments: Food- and Airborne Wallemia spp. Produce Toxic Metabolites at Hypersaline Conditions","volume":"11","author":"Jan\u010di\u010d","year":"2016","journal-title":"PLoS ONE"},{"key":"2021111620340530600_B18","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1080\/14786419.2015.1046871","article-title":"A New Steroid from the Red Sea Soft Coral Lobophytum Lobophytum","volume":"30","author":"Hegazy","year":"2015","journal-title":"Natural Products Res."},{"key":"2021111620340530600_B19","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1080\/14786419.2015.1055266","article-title":"Cytotoxic Constituents from the Red Sea Soft Coral Nephthea Sp","volume":"30","author":"Hegazy","year":"2015","journal-title":"Natural Products Res."},{"key":"2021111620340530600_B20","first-page":"510879","article-title":"Pretreatment Hepatoprotective Effect of the Marine Fungus Derived from Sponge on Hepatic Toxicity Induced by Heavy Metals in Rats","author":"Abdel Moniem","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"2021111620340530600_B21","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.22207\/JPAM.11.3.10","article-title":"Isolation,Identification and Molecular Screening of Psudomance Sp Metabolic pathways NRPs and PKS associated with the Red Sea sponge, Hyrtios aff. Erectus, Egypt","volume":"11","author":"Abd El Moneam","year":"2017","journal-title":"J. Pure Applied Microbiol."},{"key":"2021111620340530600_B22","first-page":"24","article-title":"Protective role of antioxidants capacity of Hyrtios aff. Erectus sponge extract against mixture of persistent organic pollutants (POPs)-induced hepatic toxicity in mice liver: biomarkers and ultrastructural study","volume":"27","author":"Abd El Moneam","year":"2017","journal-title":"Environ. Sci. Pollution Res."},{"key":"2021111620340530600_B23","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1080\/13102818.2018.1441747","article-title":"Hepatoprotective effect of Red Sea sponge extract against the toxicity of a real-life mixture of persistent organic pollutants","volume":"32","author":"Abd El Moneam","year":"2018","journal-title":"Biotechnol. Biotechnol. Equipment"},{"key":"2021111620340530600_B24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4172\/2325-9655.1000143","article-title":"The Ameliorative Role of a Marine Sponge Extract against Mixture of Persistent Organic Pollutants induced Changes in Hematological Parameters in Mice","volume":"6","author":"Shreadah","year":"2017","journal-title":"Expert Opinion Environ. Biol."},{"key":"2021111620340530600_B25","doi-asserted-by":"publisher","first-page":"56","DOI":"10.11648\/j.ijema.20190703.11","article-title":"Evaluation of Different Anthropogenic Effluents Impacts on the Water Quality Using Principal Component Analysis: A Case Study of Abu-Qir Bay-Alexandria-Egypt","volume":"7","author":"Shreadah","year":"2019","journal-title":"Int. J. Environ. Monitoring Analysis"},{"key":"2021111620340530600_B26","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.2174\/1573407215666191111122711","article-title":"Metabolomics and Pharmacological Screening of Aspergillus versicolor Isolated from Hyrtios Erectus Red Sea Sponge; Egypt","volume":"16","author":"Shreadah","year":"2020","journal-title":"Curr. Bioact. Compd."},{"key":"2021111620340530600_B27","doi-asserted-by":"publisher","first-page":"964","DOI":"10.2174\/1389201020666190619092502","article-title":"Pesudomance sp. Bacteria Associated with Marine Sponge as a Promising and Sustainable Source of Bioactive Molecules","volume":"20","author":"Nabil-Adam","year":"2020","journal-title":"Curr. Pharm. Biotechnol."},{"key":"2021111620340530600_B28","doi-asserted-by":"publisher","first-page":"127","DOI":"10.4274\/tjps.galenos.2018.72677","article-title":"In-vitro drug screening and biochemical analysis of sponge secondary metabolites collected from the Red Sea Egypt","volume":"17","author":"Nabil-Adam","year":"2020","journal-title":"Turkish J. Pharmaceutical Sci."},{"key":"2021111620340530600_B29","doi-asserted-by":"publisher","first-page":"01","DOI":"10.14302\/issn.2638-4469.japb-17-1534","article-title":"Industrial and Biotechnological Applications of Algae: A Review","volume":"1","author":"Sharma","year":"2017","journal-title":"J. Adv. Plant Biol."},{"key":"2021111620340530600_B30","doi-asserted-by":"publisher","first-page":"157","DOI":"10.4236\/nr.2016.74016","article-title":"Valuable Biomolecules from Nine North Atlantic Red Macroalgae: Amino Acids, Fatty Acids, Carotenoids, Minerals and Metals","volume":"7","author":"Parjikolaei","year":"2016","journal-title":"Natural Resources"},{"key":"2021111620340530600_B31","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1080\/02757540512331323953","article-title":"Gochemical forms of trace metals in mangrove sediments-Red Sea (Egypt)","volume":"21","author":"Okbah","year":"2005","journal-title":"Chem. Ecol."},{"key":"2021111620340530600_B32","first-page":"1","article-title":"Hydrography and Chemical Characteristics of the Coastal Water along the Gulf of Suez","volume":"31","author":"Fahmy","year":"2005","journal-title":"Egyptian J. Aquatic Res."},{"key":"2021111620340530600_B33","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.4236\/jep.2016.712145","article-title":"Evaluations of the Coastal Water Quality of the Egyptian Red Sea during 2011-2013","volume":"7","author":"Fahmy","year":"2016","journal-title":"J. Environ. Protection"},{"key":"2021111620340530600_B34","first-page":"64","article-title":"AlkylleadandAlkyltin Species in different fishes collected from the Suez Gulf, Egypt. Proceedings of the 2nd International Conference on Aquatic Res","volume":"34","author":"Shreadah","year":"2008","journal-title":"Egypt. J. Aqu. Res."},{"key":"2021111620340530600_B35","first-page":"83","article-title":"Application of IR, X-Ray, TGA and DTA to determine the mineral composition of the Sediments and study of reaction kinetics along the Egyptian Red Sea Coasts","volume":"34","author":"Shreadah","year":"2008","journal-title":"Egypt. J. Aqu. Res."},{"key":"2021111620340530600_B36","first-page":"16","article-title":"Physico-chemical characterititics of the surficial sediments along the Egyptian Red Sea coasts","volume":"34","author":"Shreadah","year":"2008","journal-title":"Egypt. J. Aquat. Res."},{"key":"2021111620340530600_B37","doi-asserted-by":"publisher","first-page":"545","DOI":"10.4236\/jep.2011.25063","article-title":"Distribution of Different Organotin and Organolead Compounds in Sediment of Suez Gulf","volume":"2","author":"Shreadah","year":"2011","journal-title":"J. Environ. Protection"},{"key":"2021111620340530600_B38","first-page":"1","article-title":"Assessment of Water Quality in the Red Sea using in Situ Measurements and Remote Sensing Data","volume":"35","author":"Gurguess","year":"2009","journal-title":"Egypt. J. Aqu. Res."},{"key":"2021111620340530600_B39","article-title":"Anticancer, antioxidant activity and GC-MS analysis of selectedalgal members of Chlorophyceae","volume":"8","author":"Balaji","year":"2017","journal-title":"Int. J. Pharm. Sci. Rev. Res."},{"key":"2021111620340530600_B40","first-page":"313","article-title":"Sesquiterpenoids with free-radical-scavenging properties from marine macroalga Ulva fasciata Delile","author":"Chakraborty","year":"2010","journal-title":"Food"},{"key":"2021111620340530600_B41","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","article-title":"A colourimetric method for the determination of serum glutamate-oxaloacetate and pyruvate transaminases","volume":"28","author":"Reitman","year":"1957","journal-title":"Am. J. Clin. Path."},{"key":"2021111620340530600_B42","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0009-8981(71)90365-2","article-title":"Albumin standards and the measurement of serum albumin with bromcresol green","volume":"31","author":"Doumas","year":"1971","journal-title":"Clin. Chim. Acta"},{"key":"2021111620340530600_B43","first-page":"23","volume":"15","author":"Walter","year":"1970","journal-title":"Microchem. J."},{"key":"2021111620340530600_B44","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0021-9258(18)57021-6","article-title":"Determination of serum proteins by means of the biuret reaction","volume":"177","author":"Gornail","year":"1949","journal-title":"J. Biol. Chem."},{"key":"2021111620340530600_B45","first-page":"541","volume-title":"Clinical Chemistry: Principles and Technics","author":"Henry","year":"1974"},{"key":"2021111620340530600_B46","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1021\/ac50011a034","article-title":"Spectrophotometric and kinetics investigation of the Berthelot reaction for the determination of ammonia","volume":"49","author":"Patton","year":"1977","journal-title":"Anal. Chem."},{"key":"2021111620340530600_B47","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1136\/jcp.54.5.356","article-title":"Method for the measurement of antioxidant activity in human fluids","volume":"54","author":"Koracevic","year":"2001","journal-title":"J. Clin. Pathol."},{"key":"2021111620340530600_B48","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/0076-6879(90)86135-I","article-title":"Malondialdehyde determination as index of lipid peroxidation","volume":"186","author":"Draper","year":"1990","journal-title":"Methods Enzymol."},{"key":"2021111620340530600_B49","doi-asserted-by":"publisher","first-page":"e67976","DOI":"10.1371\/journal.pone.0067976","article-title":"Measuring Myeloperoxidase Activity in Biological Samples","volume":"8","author":"Pulli","year":"2013","journal-title":"PLoS ONE"},{"key":"2021111620340530600_B50","doi-asserted-by":"crossref","DOI":"10.1097\/00000441-194208000-00028","volume-title":"The Rat in Laboratory Investigation","author":"Griffith","year":"1942"},{"key":"2021111620340530600_B51","doi-asserted-by":"publisher","first-page":"3684","DOI":"10.3748\/wjg.v25.i28.3684","article-title":"Acute kidney injury spectrum in patients with chronic liver disease: Where do we stand?","volume":"25","author":"Chancharoenthana","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"2021111620340530600_B52","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3389\/fphar.2020.00109","article-title":"Toddalolactone Protects Lipopolysaccharide-Induced Sepsis and Attenuates Lipopolysaccharide-Induced Inflammatory Response by Modulating HMGB1-NF-\u03baB Translocation","volume":"11","author":"Ni","year":"2020","journal-title":"Front. Pharmacol."},{"key":"2021111620340530600_B53","doi-asserted-by":"publisher","first-page":"4680732","DOI":"10.1155\/2017\/4680732","article-title":"The Role of CYP2E1 in the Drug Metabolism or Bioactivation in the Brain","volume":"2017","author":"Garc\u00eda-Su\u00e1stegui","year":"2017","journal-title":"Oxidative Med. Cell. Longevity"},{"key":"2021111620340530600_B54","doi-asserted-by":"publisher","first-page":"962","DOI":"10.3389\/fphar.2018.00962","article-title":"Emodin Attenuates Lipopolysaccharide-Induced Acute Liver Injury via Inhibiting the TLR4 Signaling Pathway in vitro and in vivo","volume":"9","author":"Ding","year":"2018","journal-title":"Front. Pharmacol."},{"key":"2021111620340530600_B55","first-page":"72","article-title":"Measurement and Clinical Significance of Lipid Peroxidation as a Biomarker of Oxidative Stress: Oxidative Stress in Diabetes, Atherosclerosis, and Chronic Inflammation","volume":"8","author":"Ito","year":"2019","journal-title":"Antioxidants (Basel, Switzerland)"},{"key":"2021111620340530600_B56","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.cotox.2017.11.002","article-title":"NF-\u03baB in Oxidative Stress","volume":"7","author":"Lingappan","year":"2018","journal-title":"Curr. Opin. Toxicol."},{"key":"2021111620340530600_B57","first-page":"1613","article-title":"RIPK3 mediates renal tubular epithelial cell apoptosis in endotoxininduced acute kidney injury","volume":"20","author":"Zhang","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"2021111620340530600_B58","doi-asserted-by":"publisher","first-page":"3061","DOI":"10.3390\/ijms20123061","article-title":"Anti-Inflammatory Activities of Marine Algae in Neurodegenerative Diseases","volume":"20","author":"Barbalace","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"2021111620340530600_B59","doi-asserted-by":"publisher","first-page":"4182","DOI":"10.3390\/molecules24224182","article-title":"Current Trends on Seaweeds: Looking at Chemical Composition, Phytopharmacology, and Cosmetic Applications","volume":"24","author":"Salehi","year":"2019","journal-title":"Molecules"},{"key":"2021111620340530600_B60","doi-asserted-by":"publisher","first-page":"598","DOI":"10.3390\/molecules25030598","article-title":"Xanthones, A Promising Anti-Inflammatory Scaffold: Structure, Activity, and Drug Likeness Analysis","volume":"25","author":"Feng","year":"2020","journal-title":"Molecules"},{"key":"2021111620340530600_B61","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.3390\/ijms18061290","article-title":"Propolis Diterpenes as a Remarkable Bio-Source for Drug Discovery Development: A Review","volume":"18","author":"Aminimoghadamfarouj","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"2021111620340530600_B62","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1111\/fcp.12049","article-title":"Phytol, a diterpene alcohol, inhibits the inflammatory response by reducing cytokine production and oxidative stress","volume":"28","author":"Silva","year":"2014","journal-title":"Fundam. Clin. Pharmacol."},{"key":"2021111620340530600_B63","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1111\/bph.13200","article-title":"Induction of the inflammatory regulator A20 by gibberellic acid in airway epithelial cells","volume":"173","author":"Reihill","year":"2016","journal-title":"Br. J. Pharmacol. (BJP)"},{"key":"2021111620340530600_B64","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1002\/mnfr.201100710","article-title":"The role of marine omega-3 (n-3) fatty acids in inflammatory processes, atherosclerosis and plaque stability","volume":"56","author":"Calder","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"key":"2021111620340530600_B65","doi-asserted-by":"publisher","first-page":"144","DOI":"10.3389\/fnut.2019.00144","article-title":"The Influence of Omega-3 Fatty Acids on Skeletal Muscle Protein Turnover in Health, Disuse, and Disease","volume":"4","author":"McGlory","year":"2019","journal-title":"Front. Nutr."},{"key":"2021111620340530600_B66","doi-asserted-by":"crossref","first-page":"77","DOI":"10.5650\/jos.ess16107","article-title":"Reaction and Scavenging Mechanism of \u03b2-Carotene and Zeaxanthin with Reactive Oxygen Species","volume":"66","author":"Nishino","year":"2016","journal-title":"J. Oleo Sci."},{"key":"2021111620340530600_B67","first-page":"255","article-title":"Anti-inflammatory Activity of \u03b2-Carotene, Lycopene and Tri-n-butylborane, a Scavenger of Reactive Oxygen Species","volume":"32","author":"Kawata","year":"2018","journal-title":"In Vivo"},{"key":"2021111620340530600_B68","first-page":"18","article-title":"Antioxidant Supplements and their Judicious Use","volume":"3","author":"Acharya","year":"2019","journal-title":"Acta Sci. Med. Sci."},{"key":"2021111620340530600_B69","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s11010-007-9453-2","article-title":"Antioxidant effect of the marine algae Chlorella vulgaris against naphthalene-induced oxidative stress in the albino rats","volume":"303","author":"Vijayavel","year":"2007","journal-title":"Mol. Cell Biochem."},{"key":"2021111620340530600_B70","doi-asserted-by":"crossref","first-page":"127","DOI":"10.4274\/tjps.galenos.2018.72677","article-title":"Various In Vitro Bioactivities of Secondary Metabolites Isolated from the Sponge Hyrtios aff. Erectus from the Red Sea Coast of Egypt\/Misir'in Kizil Deniz Kiyisindaki Sunger Hyrtios aff. Erectus'tan Izole Edilen Farkli Sekonder Metabolitlerin Biyoaktiviteleri","volume":"17","author":"Nabil-Adam","year":"2020","journal-title":"Turkish J. Pharmaceut. Sci."},{"key":"2021111620340530600_B71","doi-asserted-by":"publisher","first-page":"384","DOI":"10.3389\/fnins.2018.00384","article-title":"Pretreatment With Risperidone Ameliorates Systemic LPS-Induced Oxidative Stress in the Cortex and Hippocampus","volume":"12","author":"Al-Amin","year":"2018","journal-title":"Front. Neurosci."},{"key":"2021111620340530600_B72","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/3067126","article-title":"Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases","volume":"2018","author":"Oliveira","year":"2018","journal-title":"Mediators Inflamm."},{"key":"2021111620340530600_B73","doi-asserted-by":"publisher","first-page":"258","DOI":"10.3390\/jcm7090258","article-title":"Role of Vitamin A in the Immune System","volume":"7","author":"Huang","year":"2018","journal-title":"J. Clin. Med."},{"key":"2021111620340530600_B74","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3390\/nu9010068","article-title":"Retinoic Acid and Its Role in Modulating Intestinal Innate Immunity","volume":"9","author":"Czarnewski","year":"2017","journal-title":"Nutrients"},{"key":"2021111620340530600_B75","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1152\/jn.00434.2013","article-title":"Retinoic acid induces changes in electrical properties of adult neurons in a dose- and isomer-dependent manner","volume":"111","author":"Vesprini","year":"2014","journal-title":"J. Neurophysiol."},{"key":"2021111620340530600_B76","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.numecd.2018.11.006","article-title":"Effects of folic acid supplementation on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials","volume":"29","author":"Fatahi","year":"2019","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"2021111620340530600_B77","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pnpbp.2017.05.005","article-title":"Antioxidant and anti-inflammatory nutrient status, supplementation, and mechanisms in patients with schizophrenia","volume":"78","author":"Mitra","year":"2017","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"2021111620340530600_B78","doi-asserted-by":"publisher","first-page":"293S","DOI":"10.3945\/an.114.006940","article-title":"The science of fatty acids and inflammation","volume":"6","author":"Fritsche","year":"2015","journal-title":"Adv. Nutr. (Bethesda, Md.)"},{"key":"2021111620340530600_B79","first-page":"426","article-title":"The Odyssey of Bioactive Compounds in Avocado (Persea americana) and Their Health Benefits","volume":"8","author":"Bhuyan","year":"2019","journal-title":"Antioxidants (Basel, Switzerland)"},{"key":"2021111620340530600_B80","article-title":"Ethyl Iso-allocholate from a Medicinal Rice Karungkavuni Inhibits Dihydropteroate Synthase in Escherichia coli: A Molecular Docking and Dynamics Study","volume":"78","author":"Kullappan","year":"2016","journal-title":"Indian J. Pharmaceutical Sci."},{"key":"2021111620340530600_B81","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1155\/2018\/4920841","article-title":"Clinical Characteristics of Aldosterone- and Cortisol-Coproducing Adrenal Adenoma in Primary Aldosteronism","volume":"2018","author":"Tang","year":"2018","journal-title":"Int. J. Endocrinol."},{"key":"2021111620340530600_B82","first-page":"2233","article-title":"Branched amino acids as potential biomarkers in metabolic syndrome patients and as hypolipidemic compounds","volume":"13","author":"Alqaraleh","year":"2019","journal-title":"Eurasian J. Biosci."},{"key":"2021111620340530600_B83","first-page":"1613","article-title":"RIPK3 mediates renal tubular epithelial cell apoptosis in endotoxininduced acute kidney injury","volume":"20","author":"Zhang","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"2021111620340530600_B84","first-page":"181","article-title":"Current results on the biological and pharmacological activities of Indole-3-carbinol","volume":"17","author":"Kim","year":"2018","journal-title":"EXCLI J."},{"key":"2021111620340530600_B85","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s12263-009-0150-5","article-title":"CYP2E1 potentiation of LPS and TNF\u03b1-induced hepatotoxicity by mechanisms involving enhanced oxidative and nitrosative stress, activation of MAP kinases, and mitochondrial dysfunction","volume":"5","author":"Lu","year":"2010","journal-title":"Genes Nutr."},{"key":"2021111620340530600_B86","first-page":"203","article-title":"Marine Algae of the Genus Gracilaria as a Multi Products Source for different Biotechnological and Medical Applications [published online ahead of print, 2020 Jan 21]","volume":"14","author":"Shreadah","year":"2020","journal-title":"Recent Pat. Biotechnol."},{"key":"2021111620340530600_B87","first-page":"e4037","article-title":"An Overview of the Characteristics and Function of Vitamin C in Various Tissues: Relying on its Antioxidant Function","volume":"18","author":"Akbari","year":"2016","journal-title":"Zahedan J. Res. Med. Sci."}],"updated-by":[{"DOI":"10.1042\/bsr-2020-2022_cor","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000}}],"container-title":["Bioscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20202022\/922048\/bsr-2020-2022.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20202022\/922048\/bsr-2020-2022.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T15:59:54Z","timestamp":1637078394000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/bioscirep\/article\/41\/1\/BSR20202022\/227061\/Red-algae-natural-products-for-prevention-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":87,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1,29]]}},"URL":"https:\/\/doi.org\/10.1042\/bsr20202022","relation":{"is-referenced-by":[{"id-type":"doi","id":"10.1007\/s11101-025-10148-z","asserted-by":"object"}]},"ISSN":["0144-8463","1573-4935"],"issn-type":[{"value":"0144-8463","type":"print"},{"value":"1573-4935","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,1]]},"published":{"date-parts":[[2021,1]]},"article-number":"BSR20202022"}}