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A total of 145 DEPs were detected in CMS Han Chinese people who live in the plateau (CMS-HPu), among which 89 were significantly up-regulated and 56 were significantly down-regulated. GO enrichment analysis showed that various biological processes were enriched, including the hydrogen peroxide metabolic\/catabolic process, reactive oxygen species (ROS) metabolic, and acute inflammatory response. Protein\u2013protein interaction analysis showed that antioxidant activity, the hydrogen peroxide catabolic process and peroxidase activity were primarily mapped in interaction proteins. Nine modules showed significantly clustering based on WGCNA analysis, with two being the most significant, and GO analysis showed that proteins of both modules were primarily enriched in oxidative stress-related biological processes. Four DEPs increased in CMS patients were evaluated as the candidate biomarkers, and three showed significant AUC: hemoglobin \u03b2 chain (HB-\u03b2), thioredoxin-1 (TRX1), and phosphoglycerate kinase 1 (PGK1). The present study provides insights into the pathogenesis of CMS and further evaluates the potentially biomarkers for its prevention and treatment of it.<\/jats:p>","DOI":"10.1042\/bsr20202219","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T10:14:03Z","timestamp":1609755243000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Novel insights into plasma biomarker candidates in patients with chronic mountain sickness based on proteomics"],"prefix":"10.1042","volume":"41","author":[{"given":"Peili","family":"Zhang","sequence":"first","affiliation":[{"name":"Research Center for High Altitude Medicine, Qinghai University, Xining, China"},{"name":"Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province, Xining, China"},{"name":"Department of General Practice, Huadu District People\u2019s Hospital, Southern Medical University, Guangzhou, 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