{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:00:36Z","timestamp":1787497236530,"version":"build-2736575974"},"reference-count":62,"publisher":"Portland Press Ltd.","issue":"1","license":[{"start":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T00:00:00Z","timestamp":1610582400000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Objective: \u00b4Three formulas and three medicines,\u2019 namely, Jinhua Qinggan Granule, Lianhua Qingwen Capsule, Xuebijing Injection, Qingfei Paidu Decoction, HuaShi BaiDu Formula, and XuanFei BaiDu Granule, were proven to be effective for coronavirus disease 2019 (COVID-19) treatment. The present study aimed to identify the active chemical constituents of this traditional Chinese medicine (TCM) and investigate their mechanisms through interleukin-6 (IL-6) integrating network pharmacological approaches.<\/jats:p>\n                  <jats:p>Methods: We collected the compounds from all herbal ingredients of the previously mentioned TCM, but those that could down-regulate IL-6 were screened through the network pharmacology approach. Then, we modeled molecular docking to evaluate the binding affinity between compounds and IL-6. Furthermore, we analyzed the biological processes and pathways of compounds. Finally, we screened out the core genes of compounds through the construction of the protein\u2013protein interaction network and the excavation of gene clusters of compounds.<\/jats:p>\n                  <jats:p>Results: The network pharmacology research showed that TCM could decrease IL-6 using several compounds, such as quercetin, ursolic acid, luteolin, and rutin. Molecular docking results showed that the molecular binding affinity with IL-6 of all compounds except \u03b3-aminobutyric acid was &amp;lt; \u22125.0 kJ\/mol, indicating the potential of numerous active compounds in TCM to directly interact with IL-6, leading to an anti-inflammation effect. Finally, Cytoscape 3.7.2 was used to topologize the biological processes and pathways of compounds, revealing potential mechanisms for COVID-19 treatment.<\/jats:p>\n                  <jats:p>Conclusion: These results indicated the positive effect of TCM on the prevention and rehabilitation of COVID-19 in at-risk people. Quercetin, ursolic acid, luteolin, and rutin could inhibit COVID-19 by down-regulating IL-6.<\/jats:p>","DOI":"10.1042\/bsr20202583","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T09:41:41Z","timestamp":1604482901000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["Network pharmacology for the identification of phytochemicals in traditional Chinese medicine for COVID-19 that may regulate interleukin-6"],"prefix":"10.1042","volume":"41","author":[{"given":"Wen-hao","family":"Niu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Affiliated hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-yue","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zong-gui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chieh","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Nursing, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4042-206X","authenticated-orcid":false,"given":"Chun","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2021,1,14]]},"reference":[{"key":"2021111620323754600_B1","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"A Novel Coronavirus from Patients with Pneumonia in China, 2019","volume":"382","author":"Zhu","year":"2020","journal-title":"N. 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