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The present study aimed to investigate the possible effect and mechanism of strontium ranelate (SR), a clinically safe drug for osteoporosis, on particle-induced periprosthetic osteolysis. Thirty-six female C57BL\/6j mice underwent tibial Ti-nail implantation to establish an animal model of aseptic loosening. After 12 weeks, micro-CT results showed that strontium ranelate could inhibit periprosthetic bone resorption. In vitro, Ti particles were used to stimulate RAW264.7 cell line to collect conditioned medium, and co-culture MC3T3-E1 cell line with conditioned medium to establish a cell model of aseptic loosening. The results of alkaline phosphatase (ALP) detection, immunofluorescence, and flow cytometry demonstrated that strontium ranelate could regulate the expression of OPG\/RANKL, promote differentiation and mineralization, and inhibit apoptosis in osteoblasts. Moreover, we revealed that SR\u2019s exerted its therapeutic effect by down-regulating sclerostin, thereby activating the Wnt\/\u03b2-catenin signal pathway. Therefore, this research suggests that strontium ranelate could be a potential drug for the prevention and treatment of particle-induced aseptic loosening post-TJA.<\/jats:p>","DOI":"10.1042\/bsr20203003","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T07:12:22Z","timestamp":1610608342000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The effect of strontium ranelate on titanium particle-induced periprosthetic osteolysis regulated by WNT\/\u03b2-catenin signaling\n                    <i>in vivo<\/i>\n                    and\n                    <i>in vitro<\/i>"],"prefix":"10.1042","volume":"41","author":[{"given":"Bolun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Ningxia Medical University, 1160 Shengli Street, Xingqing Area, Yinchuan, Ningxia, P.R. China 750004"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haohui","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, General Hospital of Ningxia Medical University, 804 Shengli Street, Xingqing Area, Yinchuan, Ningxia, P.R. China 750004"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxiang","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Ningxia Medical University, 1160 Shengli Street, Xingqing Area, Yinchuan, Ningxia, P.R. China 750004"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kening","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, General Hospital of Ningxia Medical University, 804 Shengli Street, Xingqing Area, Yinchuan, Ningxia, P.R. 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