{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:38:56Z","timestamp":1778891936999,"version":"3.51.4"},"reference-count":39,"publisher":"Portland Press Ltd.","issue":"1","license":[{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Survivin is an inhibitor of apoptosis as well as a promoter of cell proliferation. Fibulin-3 is a matrix glycoprotein that displays potential for tumor suppression or propagation. The present study aimed to validate the expression levels of survivin and fibulin-3 in benign and malignant respiratory diseases. This case\u2013control study included 219 patients categorized into five groups. Group A included 63 patients with lung cancer, group B included 63 patients with various benign lung diseases, group D included 45 patients with malignant pleural mesothelioma (MPM), and group E included 48 patients with various benign pleural diseases. Group C included 60 healthy individuals (control group). Serum survivin and fibulin-3 levels were measured by ELISA, whereas their nuclear expressions in the lung and pleura were assessed via Western blot analysis. The results showed significantly higher survivin serum levels and significantly lower fibulin-3 levels in group A compared with in group B and controls (P&amp;lt;0.001). There were significantly higher serum levels of survivin and fibulin-3 in group D compared with in group E and controls (P&amp;lt;0.001), consistent with observed nuclear survivin and fibulin-3 expression levels. Fibulin-3 was determined to have higher value than survivin in discriminating lung cancer from MPM (P&amp;lt;0.05). Survivin and fibulin-3 could be useful diagnostic markers for lung and pleural cancers, and fibulin-3 expression was particularly useful in differentiating lung cancer from MPM.<\/jats:p>","DOI":"10.1042\/bsr20203097","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T06:47:07Z","timestamp":1606114027000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Circulating and local nuclear expression of survivin and fibulin-3 genes in discriminating benign from malignant respiratory diseases: correlation analysis"],"prefix":"10.1042","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2698-9438","authenticated-orcid":false,"given":"Mohammed\u00a0H.","family":"Hassan","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine, South Valley University, Qena, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sawsan","family":"Abuhamdah","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Al Ain University, Abu Dhabi, UAE"},{"name":"Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, The University of Jordan, Amman, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Abdel-Bary","sequence":"additional","affiliation":[{"name":"Department of Cardio-Thoracic Surgery, Faculty of Medicine, South Valley University, Qena, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Wahman","sequence":"additional","affiliation":[{"name":"Department of Oncology and Nuclear Medicine, Faculty of Medicine, South Valley University, Qena, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek\u00a0Hamdy","family":"Abd-Elhamid","sequence":"additional","affiliation":[{"name":"Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morris","family":"Beshay","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery, Protestant Hospital of Bethel Foundation, Burgsteig 13, Bielefeld, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karam","family":"Mosallam","sequence":"additional","affiliation":[{"name":"Department of Cardio-Thoracic Surgery, Faculty of Medicine, South Valley University, Qena, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bakheet\u00a0E.M.","family":"Elsadek","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, 71524 Assiut, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2021,1,6]]},"reference":[{"key":"2021111620335464700_B1","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1007\/s00428-006-0239-9","article-title":"Survivin expression in pre-invasive lesions and non-small cell lung carcinoma","volume":"449","author":"Aky\u00fcrek","year":"2006","journal-title":"Virchows. 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