{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:29:28Z","timestamp":1790620168018,"version":"4.1.0"},"reference-count":16,"publisher":"Portland Press Ltd.","issue":"2","license":[{"start":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:00:00Z","timestamp":1609891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,2,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Infection of burn wounds often leads to poor healing, sepsis, disability, or even death. Traditional care focuses on early debridement, fluid resuscitation, and intravenous antibiotics but these are often inadequate due to compromised vasculature limiting systemic antibiotics effectiveness. Biofilms in burn wounds are barriers to treatment and are associated with the transition of wounds from acute to chronic non-healing state. Current topical treatments for burn wounds include skin substitutes impregnated with skin or stem cells that promote healing; or hydrogels delivering an antibiotic, silver, or synthetic antimicrobial peptides. The success of currently available products is varied and, in some cases, very limited due to associated cytotoxicity to mammalian cells, the ability to only fight extracellular biofilm infections, and the ever-increasing development of antimicrobial resistance (AMR). There is, therefore, a high clinical need for the development of next-generation hydrogel wound dressings, to combat bacterial burn wound infection. A recent paper by Khan et al. (Bioscience Reports (2020) 39, https:\/\/doi.org\/10.1042\/BSR20190504) highlights the development of a catechol cross-linked antimicrobial peptide hydrogel, adding to the body of literature describing innovative solutions with better delivery systems for antimicrobial peptides, and identifying a promising future biomaterial for development of novel hydrogel dressing to combat multi-drug resistant bacterial infections in burn wounds.<\/jats:p>","DOI":"10.1042\/bsr20203404","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T13:29:03Z","timestamp":1610285343000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Development of next-generation antimicrobial hydrogel dressing to combat burn wound infection"],"prefix":"10.1042","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8072-4222","authenticated-orcid":false,"given":"Zlatko","family":"Kopecki","sequence":"first","affiliation":[{"name":"Future Industries Institute, University of South Australia, Adelaide, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2021,2,8]]},"reference":[{"key":"2021111620374808700_B1","doi-asserted-by":"publisher","first-page":"66","DOI":"10.12968\/jowc.2019.28.2.66","article-title":"Biofilm formation and antibiotic resistance in meticillin-resistant and meticillin-sensitive Staphylococcus aureus isolated from burns","volume":"28","author":"Mahmoudi","year":"2019","journal-title":"J. Wound Care"},{"key":"2021111620374808700_B2","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1089\/sur.2013.134","article-title":"Infection in burns","volume":"17","author":"Norbury","year":"2016","journal-title":"Surg. Infect. (Larchmt)"},{"key":"2021111620374808700_B3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.addr.2017.09.018","article-title":"Burn injury: challenges and advances in burn wound healing, infection, pain and scarring","volume":"123","author":"Wang","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"2021111620374808700_B4","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1097\/00002727-200108000-00009","article-title":"Infected wound management: advanced technologies, moisture-retentive dressings, and die-hard methods","volume":"24","author":"Campton-Johnston","year":"2001","journal-title":"Crit. Care Nurs. Q"},{"key":"2021111620374808700_B5","doi-asserted-by":"publisher","first-page":"5782","DOI":"10.2174\/0929867324666170920161246","article-title":"Hydrogel dressings for advanced wound management","volume":"25","author":"Francesko","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"2021111620374808700_B6","doi-asserted-by":"publisher","first-page":"2853","DOI":"10.3390\/ma13122853","article-title":"Hydrogel dressings for the treatment of burn wounds: an up-to-date overview","volume":"13","author":"Stoica","year":"2020","journal-title":"Materials (Basel)"},{"key":"2021111620374808700_B7","doi-asserted-by":"publisher","first-page":"2983","DOI":"10.1021\/acs.biomac.0c00760","article-title":"Natural polymer-based antimicrobial hydrogels without synthetic antibiotics as wound dressings","volume":"21","author":"Zhong","year":"2020","journal-title":"Biomacromolecules"},{"key":"2021111620374808700_B8","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics11080407","article-title":"Strategies for hyaluronic acid-based hydrogel design in drug delivery","volume":"11","author":"Trombino","year":"2019","journal-title":"Pharmaceutics"},{"key":"2021111620374808700_B9","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1039\/C9CS00285E","article-title":"Catechol-functionalized hydrogels: biomimetic design, adhesion mechanism, and biomedical applications","volume":"49","author":"Zhang","year":"2020","journal-title":"Chem. Soc. Rev."},{"key":"2021111620374808700_B10","doi-asserted-by":"publisher","first-page":"41011","DOI":"10.1021\/acsami.0c09414","article-title":"Ultrasmall AgNP-impregnated biocompatible hydrogel with highly effective biofilm elimination properties","volume":"12","author":"Haidari","year":"2020","journal-title":"ACS Appl. Mater Interfaces."},{"key":"2021111620374808700_B11","first-page":"6","article-title":"Fighting chronic wound infection: one model at a time","volume":"25","author":"Kopecki","year":"2017","journal-title":"Wound Pract. Res."},{"key":"2021111620374808700_B12","doi-asserted-by":"publisher","first-page":"e0200195","DOI":"10.1371\/journal.pone.0200195","article-title":"Bioluminescent murine models of bacterial sepsis and scald wound infections for antimicrobial efficacy testing","volume":"13","author":"Ogunniyi","year":"2018","journal-title":"PLoS ONE"},{"key":"2021111620374808700_B13","doi-asserted-by":"publisher","first-page":"BSR20190504","DOI":"10.1042\/BSR20190504","article-title":"Catechol cross-linked antimicrobial peptide hydrogels prevent multidrug-resistant Acinetobacter baumannii infection in burn wounds","volume":"39","author":"Khan","year":"2019","journal-title":"Biosci. Rep."},{"key":"2021111620374808700_B14","doi-asserted-by":"publisher","first-page":"6619","DOI":"10.1007\/s00253-016-7677-3","article-title":"Recent advances in the biotechnological production of microbial poly(varepsilon-L-lysine) and understanding of its biosynthetic mechanism","volume":"100","author":"Xu","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"2021111620374808700_B15","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/s41427-020-0206-y","article-title":"An injectable photopolymerized hydrogel with antimicrobial and biocompatible properties for infected skin regeneration","volume":"12","author":"Sun","year":"2020","journal-title":"NPG Asia Mater."},{"key":"2021111620374808700_B16","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.actbio.2018.10.037","article-title":"Biomimetic recyclable microgels for on-demand generation of hydrogen peroxide and antipathogenic application","volume":"83","author":"Meng","year":"2019","journal-title":"Acta Biomater."}],"container-title":["Bioscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20203404\/903883\/bsr-2020-3404c.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20203404\/903883\/bsr-2020-3404c.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T16:02:06Z","timestamp":1637078526000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/bioscirep\/article\/41\/2\/BSR20203404\/227512\/Development-of-next-generation-antimicrobial"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2,26]]}},"URL":"https:\/\/doi.org\/10.1042\/bsr20203404","relation":{},"ISSN":["0144-8463","1573-4935"],"issn-type":[{"value":"0144-8463","type":"print"},{"value":"1573-4935","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,2]]},"published":{"date-parts":[[2021,2]]},"article-number":"BSR20203404"}}