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Fluorometric assay was employed to determine the DPP-IV activity. For in vivo studies, HFF obese-diabetic rats were fasted for 6 h and blood was sampled at different times before and after the oral administration of the glucose alone (18 mmol\/kg body weight) or with either of the four most active plant extracts (250 mg\/5 ml\/kg, body weight) or established DPP-IV inhibitors (10 \u03bcmol\/5 ml\/kg). DPP-IV inhibitors: sitagliptin, vildagliptin and diprotin A, decreased enzyme activity by a maximum of 95\u201399% (P&amp;lt;0.001). Among the 22 natural anti-diabetic plants tested, AnogeissusLatifolia exhibited the most significant (P&amp;lt;0.001) inhibitory activity (96 \u00b1 1%) with IC50 and IC25 values of 754 and 590 \u03bcg\/ml. Maximum inhibitory effects of other extracts: Aegle marmelos, Mangifera indica, Chloropsis cochinchinensis, Trigonella foenum-graecum and Azadirachta indica were (44 \u00b17%; 38 \u00b1 4%; 31\u00b11%; 28\u00b12%; 27\u00b12%, respectively). A maximum of 45% inhibition was observed with &amp;gt;25 \u03bcM concentrations of selected phytochemicals (rutin). A.latifolia, A. marmelos, T. foenum-graecum and M. indica extracts improved glucose tolerance, insulin release, reduced DPP-IV activity and increased circulating active GLP-1 in HFF obese-diabetic rats (P&amp;lt;0.05\u20130.001). These results suggest that ingestion of selected natural anti-diabetic plants, in particular A. latifolia, A. marmelos, T. foenum-graecum and M. indica can substantially inhibit DPP-IV and improve glucose homeostasis, thereby providing a useful therapeutic approach for the treatment of T2DM.<\/jats:p>","DOI":"10.1042\/bsr20203824","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T21:33:32Z","timestamp":1610573612000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Effects of 22 traditional anti-diabetic medicinal plants on DPP-IV enzyme activity and glucose homeostasis in high-fat fed obese diabetic rats"],"prefix":"10.1042","volume":"41","author":[{"given":"Prawej","family":"Ansari","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences, Ulster University, Coleraine, BT52 1SA, Co. Londonderry, Northern Ireland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary\u00a0P.","family":"Hannon-Fletcher","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Ulster University, Coleraine, BT52 1SA, Co. Londonderry, Northern Ireland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter\u00a0R.","family":"Flatt","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Ulster University, Coleraine, BT52 1SA, Co. Londonderry, Northern Ireland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3991-3419","authenticated-orcid":false,"given":"Yasser\u00a0H.A.","family":"Abdel-Wahab","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Ulster University, Coleraine, BT52 1SA, Co. 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