{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:26:39Z","timestamp":1777908399526,"version":"3.51.4"},"reference-count":43,"publisher":"Portland Press Ltd.","issue":"2","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,2,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Giardiasis is one of the most prevalent gastrointestinal diseases in the world. It is caused by Giardia, Giardia lamblia, a common and opportunistic zoonotic parasite. The aim of our work is to find a natural and safe alternative treatment for giardiasis, specifically, to determine if probiotic bacteria (Lactobacillus acidophilus, Bifidobacterium bifidum, and Lactobacillus helveticus) can contribute to treatment, and act as preventives. Sixty weanling albino mice, Mus musculus, were divided into control and experimental, probiotic-fed groups. We determined infection intensity, and cure and prevention rates of giardiasis through ELISA (enzyme-linked immunosorbent assay) of stool samples and histopathological comparison of intestinal tissue. In experimental groups, there was a significant reduction in infection intensity (P&amp;lt;0.001) on days 10, 15, and 20, while cure rate reached 87.5%. The control group showed no signs of reduced infection or cure and only the group treated with probiotics prior to infection showed significant prevention rates. In the experimental groups, intestinal changes due to giardiasis appeared 7 days post-infection. However, almost all of these changes disappeared by the 25th day. Our results suggest a beneficial and significant effect of probiotics in the prevention and treatment of giardiasis in mice.<\/jats:p>","DOI":"10.1042\/bsr20204114","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T19:12:34Z","timestamp":1613675554000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Preventive role of probiotic bacteria against gastrointestinal diseases in mice caused by\n                    <i>Giardia lamblia<\/i>"],"prefix":"10.1042","volume":"41","author":[{"given":"Wafa\u00a0A.","family":"Al-Megrin","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Science, Princess Nourah bint Abdulrahman University, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shadia\u00a0H.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Science, Ain Shams University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moudy\u00a0M.","family":"Saleh","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Science, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5387-8026","authenticated-orcid":false,"given":"Hany\u00a0M.","family":"Yehia","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, College of Food and Agriculture Science, King Saud University, Riyadh 11451, Saudi Arabia"},{"name":"Department of Food Science and Nutrition, Faculty of Home Economics, Helwan University, Cairo 11221, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2021,2,22]]},"reference":[{"key":"2022042611562727000_B1","first-page":"683","article-title":"Antigiardial effect of kramecyne in experimental giardiasis","volume":"201","author":"Eligio-Garcia","year":"2017","journal-title":"Evid. 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