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The transplantation of mesenchymal stem cells (MSCs), a type of bone marrow stem cells, has been considered a potential therapy for patients with solid tumors due to their capability to enhance the immune response; MSC transplantation has received renewed interest in recent years. The present study aimed to evaluate the antiapoptotic effects of the MSCs on 1,2-dimethylhydrazine (DMH)-induced inflammation in the rat model of colorectal cancer. The rats were randomly allocated into four groups: control, treated with MSCs, induced by DMH, and induced by DMH and treated with MSCs. The MSCs were intra-rectally injected, and DMH was subcutaneously injected at 20 mg\/kg body weight once a week for 15 weeks. The administration of MSCs into rats starting from day 0 of the DMH injection was found to enhance the histopathological picture. The MSC treatment resulted in fewer inflammatory cells than in the DMH group. Therefore, our findings suggest that BMCs have antitumor effects by modulating the cellular redox status and down-regulating the pro-inflammatory genes. Thus, BMCs may provide therapeutic value for colon cancer treatment.<\/jats:p>","DOI":"10.1042\/bsr20204356","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T04:51:45Z","timestamp":1613710305000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effect of mesenchymal stem cells on cytochrome-\n                    <i>c<\/i>\n                    release and inflammation in colon cancer induced by 1,2-dimethylhydrazine in Wistar albino rats"],"prefix":"10.1042","volume":"41","author":[{"given":"Afrah F.","family":"Alkhuriji","sequence":"first","affiliation":[{"name":"Department of Zoology, College of Science, King Saud University, Riyadh 11495, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seham G.","family":"Alsaiari","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science, King Saud University, Riyadh 11495, Saudi Arabia"},{"name":"Department of Biology, Al-Nairiyah University College, University of Hafr Al-Batin, Hafr Al-Batin 31991, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suliman Y.","family":"Alomar","sequence":"additional","affiliation":[{"name":"Doping Research Chair, Department of Zoology, College of Science, King Saud University, 11 Riyadh 11495, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa A.","family":"Alnafjan","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science, King Saud University, Riyadh 11495, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussah","family":"Alobaid","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science, King Saud University, Riyadh 11495, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5457-6791","authenticated-orcid":false,"given":"Manal F.","family":"El-Khadragy","sequence":"additional","affiliation":[{"name":"Biology Department, Faculty of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia"},{"name":"Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo 11795, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2021,3,2]]},"reference":[{"key":"2021111620401832400_B1","first-page":"1815","article-title":"Colon cancer and Saudi population","volume":"4","author":"Alharbi","year":"2017","journal-title":"Int. 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