{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:37:39Z","timestamp":1787668659430,"version":"build-2736575974"},"reference-count":26,"publisher":"Portland Press Ltd.","issue":"5","license":[{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,5,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>MicroRNA-543-3p (miR-543-3p) has been reported to be involved in many human disease\u2019s progression, but its role in inflammation is still unclear. After bacterial infection, innate immune cells are activated to trigger inflammation by recognizing lipopolysaccharide (LPS) on the bacterial outer membrane. In our research, it showed that miR-543-3p was down-regulated in LPS-treated periodontal ligament cells (PDLCs). And it mediated the apoptosis of PDLC induced by LPS, which may be involved in periodontitis development. Besides, up-regulation of miR-543-3p alleviated the inflammatory damage induced by LPS. Furthermore, our research demonstrated Kruppel-like factor 6 (KLF6) served as a direct downstream target of miR-543-3p to play a vital role in periodontitis. Simply put, these findings suggest that miR-543-3p could down-regulate inflammation and inhibit periodontitis by targeting KLF6, and it provides a new insight into the molecular mechanism of periodontitis, which may be helpful for the early diagnosis and treatment of this disease.<\/jats:p>","DOI":"10.1042\/bsr20210138","type":"journal-article","created":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T04:16:53Z","timestamp":1620361013000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["MicroRNA-543-3p down-regulates inflammation and inhibits periodontitis through KLF6"],"prefix":"10.1042","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4747-5188","authenticated-orcid":false,"given":"Wei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Stomatology, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Shinan District, Qingdao 266000, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Qingdao Women and Children\u2019s Hospital. No. 6 Tongfu Road, Shibei District, Qingdao 266000, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Stomatology, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Shinan District, Qingdao 266000, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuifang","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Qingdao Agricultural University. No. 700 Changcheng Road, Chengyang District, Qingdao 266109, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2021,5,21]]},"reference":[{"key":"2021111620460879600_B1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/prd.12104","article-title":"Molecular aspects of the pathogenesis of periodontitis","volume":"69","author":"Meyle","year":"2015","journal-title":"Periodontol. 2000"},{"key":"2021111620460879600_B2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/prd.12221","article-title":"Periodontitis: facts, fallacies and the future","volume":"75","author":"Slots","year":"2017","journal-title":"Periodontol. 2000"},{"key":"2021111620460879600_B3","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1023\/A:1022344031223","article-title":"Activation of transcription factors and IL-8 expression in neutrophils stimulated with lipopolysaccharide from Porphyromonas gingivalis","volume":"22","author":"Sugita","year":"1998","journal-title":"Inflammation"},{"key":"2021111620460879600_B4","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1034\/j.1600-0765.2001.360304.x","article-title":"Elevated mRNA expression for supervillin and vascular endothelial growth factor in human neutrophils stimulated with lipopolysaccharide from Porphyromonas gingivalis","volume":"36","author":"Morozumi","year":"2001","journal-title":"J. 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