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Obesity is highly prevalent worldwide and is considered a risk factor for impairing the adaptive immune system. Although diabetes, hypertension, cardiovascular disease (CVD), and renal failure are considered the risk factors for COVID-19, obesity is not yet well-considered. The present study approaches establishing a systemic association between the prevalence of obesity and its impact on immunity concerning the severe outcomes of COVID-19 utilizing existing knowledge. Overall study outcomes documented the worldwide prevalence of obesity, its effects on immunity, and a possible underlying mechanism covering obesity-related risk pathways for the severe outcomes of COVID-19. Overall understanding from the present study is that being an immune system impairing factor, the role of obesity in the severe outcomes of COVID-19 is worthy.<\/jats:p>","DOI":"10.1042\/bsr20210979","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T12:12:44Z","timestamp":1628165564000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Obesity, a major risk factor for immunity and severe outcomes of COVID-19"],"prefix":"10.1042","volume":"41","author":[{"given":"Mohammad\u00a0Tohidul","family":"Amin","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaniz","family":"Fatema","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry and Chemical Engineering, Noakhali Science and Technology University, Noakhlai-3814, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayema","family":"Arefin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipty\u00a0Rani","family":"Bhowmik","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5710-1115","authenticated-orcid":false,"given":"Mohammad\u00a0Salim","family":"Hossain","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2021,8,20]]},"reference":[{"key":"2021111620512472200_B1","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1056\/NEJMoa2001316","article-title":"Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia","volume":"382","author":"Li","year":"2020","journal-title":"N. 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