{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:49:40Z","timestamp":1784033380096,"version":"3.55.0"},"reference-count":153,"publisher":"Portland Press Ltd.","issue":"3","license":[{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,3,31]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The impact of birth asphyxia and its sequelae, hypoxic\u2013ischaemic (HI) brain injury, is long-lasting and significant, both for the infant and for their family. Treatment options are limited to therapeutic hypothermia, which is not universally successful and is unavailable in low resource settings. The energy deficits that accompany neuronal death following interruption of blood flow to the brain implicate mitochondrial dysfunction. Such HI insults trigger mitochondrial outer membrane permeabilisation leading to release of pro-apoptotic proteins into the cytosol and cell death. More recently, key players in mitochondrial fission and fusion have been identified as targets following HI brain injury. This review aims to provide an introduction to the molecular players and pathways driving mitochondrial dynamics, the regulation of these pathways and how they are altered following HI insult. Finally, we review progress on repurposing or repositioning drugs already approved for other indications, which may target mitochondrial dynamics and provide promising avenues for intervention following brain injury. Such repurposing may provide a mechanism to fast-track, low-cost treatment options to the clinic.<\/jats:p>","DOI":"10.1042\/bsr20211696","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T08:47:12Z","timestamp":1648025232000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Mitochondrial dynamics in the neonatal brain \u2013 a potential target following injury?"],"prefix":"10.1042","volume":"42","author":[{"given":"Adam","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, London SE1 7EH, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7676-3272","authenticated-orcid":false,"given":"Claire","family":"Thornton","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedical Sciences, Royal Veterinary College, London NW1 0TU, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2022,3,23]]},"reference":[{"key":"2022032308470118100_B1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1159\/000508054","article-title":"Brain fuel utilization in the developing brain","volume":"75","author":"Steiner","year":"2019","journal-title":"Ann. Nutr. Metab."},{"key":"2022032308470118100_B2","doi-asserted-by":"publisher","first-page":"11338","DOI":"10.3390\/ijms222111338","article-title":"Mitochondria as a cellular hub in infection and inflammation","volume":"22","author":"Andrieux","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2022032308470118100_B3","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.3390\/biom11071012","article-title":"Mitostasis, calcium and free radicals in health, aging and neurodegeneration","volume":"11","author":"Godoy","year":"2021","journal-title":"Biomolecules"},{"key":"2022032308470118100_B4","doi-asserted-by":"publisher","first-page":"183716","DOI":"10.1016\/j.bbamem.2021.183716","article-title":"Apoptosis regulation at the mitochondria membrane level","volume":"1863","author":"Dadsena","year":"2021","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"2022032308470118100_B5","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1016\/j.tcb.2019.08.003","article-title":"The good and the bad of mitochondrial breakups","volume":"29","author":"Sprenger","year":"2019","journal-title":"Trends Cell Biol."},{"key":"2022032308470118100_B6","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1002\/1873-3468.14077","article-title":"Mitochondrial dynamics in health and disease","volume":"595","author":"Yapa","year":"2021","journal-title":"FEBS Lett."},{"key":"2022032308470118100_B7","doi-asserted-by":"publisher","first-page":"5785","DOI":"10.3390\/ijms21165785","article-title":"The mitochondrial dysfunction hypothesis in autism spectrum disorders: current status and future perspectives","volume":"21","author":"Citrigno","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"2022032308470118100_B8","doi-asserted-by":"publisher","first-page":"2959","DOI":"10.1007\/s12035-020-01926-1","article-title":"The role of mitochondria in neurodegenerative diseases: the lesson from Alzheimer\u2019s disease and Parkinson\u2019s disease","volume":"57","author":"Monzio Compagnoni","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"2022032308470118100_B9","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.3390\/antiox10091384","article-title":"The alterations in mitochondrial dynamics following cerebral ischemia\/reperfusion injury","volume":"10","author":"Vongsfak","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"2022032308470118100_B10","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s10863-014-9589-1","article-title":"Evidence to support mitochondrial neuroprotection, in severe traumatic brain injury","volume":"47","author":"Gajavelli","year":"2015","journal-title":"J. Bioenerg. Biomembr."},{"key":"2022032308470118100_B11","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1089\/ars.2018.7606","article-title":"Mitochondria, metabolism, and redox mechanisms in psychiatric disorders","volume":"31","author":"Kim","year":"2019","journal-title":"Antioxid. Redox Signal."},{"key":"2022032308470118100_B12","doi-asserted-by":"publisher","first-page":"4892","DOI":"10.1111\/jcmm.15194","article-title":"Mitochondrial biogenesis: an update","volume":"24","author":"Popov","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"2022032308470118100_B13","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1038\/s41556-018-0176-2","article-title":"Mechanisms of mitophagy in cellular homeostasis, physiology and pathology","volume":"20","author":"Palikaras","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"2022032308470118100_B14","doi-asserted-by":"publisher","first-page":"373","DOI":"10.3389\/fncel.2019.00373","article-title":"Axonal transport and mitochondrial function in neurons","volume":"13","author":"Mandal","year":"2019","journal-title":"Front. Cell Neurosci."},{"key":"2022032308470118100_B15","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1126\/science.1219855","article-title":"Mitochondrial fission, fusion, and stress","volume":"337","author":"Youle","year":"2012","journal-title":"Science"},{"key":"2022032308470118100_B16","doi-asserted-by":"publisher","first-page":"e41351","DOI":"10.7554\/eLife.41351","article-title":"Mitochondrial fusion supports increased oxidative phosphorylation during cell proliferation","volume":"8","author":"Yao","year":"2019","journal-title":"eLife"},{"key":"2022032308470118100_B17","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.ceca.2016.04.006","article-title":"Mitochondrial remodeling: rearranging, recycling, and reprogramming","volume":"60","author":"Gottlieb","year":"2016","journal-title":"Cell Calcium"},{"key":"2022032308470118100_B18","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.tem.2015.12.001","article-title":"Mitochondrial dynamics and metabolic regulation","volume":"27","author":"Wai","year":"2016","journal-title":"Trends Endocrinol. Metab."},{"key":"2022032308470118100_B19","doi-asserted-by":"publisher","first-page":"4061","DOI":"10.1073\/pnas.1919116117","article-title":"Structural analysis of a trimeric assembly of the mitochondrial dynamin-like GTPase Mgm1","volume":"117","author":"Yan","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2022032308470118100_B20","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s00109-015-1359-y","article-title":"Restoration of Opa1-long isoform inhibits retinal injury-induced neurodegeneration","volume":"94","author":"Sun","year":"2015","journal-title":"J. Mol. Med. (Berl.)"},{"key":"2022032308470118100_B21","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1083\/jcb.200704110","article-title":"OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L","volume":"178","author":"Song","year":"2007","journal-title":"J. Cell Biol."},{"key":"2022032308470118100_B22","doi-asserted-by":"publisher","first-page":"2966","DOI":"10.1038\/sj.emboj.7601184","article-title":"Regulation of mitochondrial morphology through proteolytic cleavage of OPA1","volume":"25","author":"Ishihara","year":"2006","journal-title":"EMBO J."},{"key":"2022032308470118100_B23","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1042\/BC20070110","article-title":"Metalloprotease-mediated OPA1 processing is modulated by the mitochondrial membrane potential","volume":"100","author":"Guillery","year":"2008","journal-title":"Biol. Cell"},{"key":"2022032308470118100_B24","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/sj.cdd.4402048","article-title":"OPA1 alternate splicing uncouples an evolutionary conserved function in mitochondrial fusion from a vertebrate restricted function in apoptosis","volume":"14","author":"Olichon","year":"2007","journal-title":"Cell Death Differ."},{"key":"2022032308470118100_B25","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1038\/ncb3560","article-title":"Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin","volume":"19","author":"Ban","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"2022032308470118100_B26","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.cmet.2015.04.016","article-title":"Opa1 overexpression ameliorates the phenotype of two mitochondrial disease mouse models","volume":"21","author":"Civiletto","year":"2015","journal-title":"Cell Metab."},{"key":"2022032308470118100_B27","doi-asserted-by":"publisher","first-page":"e2309","DOI":"10.1038\/cddis.2016.160","article-title":"Mitochondrial dysfunction in an Opa1(Q285STOP) mouse model of dominant optic atrophy results from Opa1 haploinsufficiency","volume":"7","author":"Kushnareva","year":"2016","journal-title":"Cell Death Dis."},{"key":"2022032308470118100_B28","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/j.cmet.2015.05.007","article-title":"The OPA1-dependent mitochondrial cristae remodeling pathway controls atrophic, apoptotic, and ischemic tissue damage","volume":"21","author":"Varanita","year":"2015","journal-title":"Cell Metab."},{"key":"2022032308470118100_B29","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1042\/EBC20170104","article-title":"Mitochondrial dynamics: overview of molecular mechanisms","volume":"62","author":"Tilokani","year":"2018","journal-title":"Essays Biochem."},{"key":"2022032308470118100_B30","doi-asserted-by":"publisher","first-page":"C583","DOI":"10.1152\/ajpcell.00523.2018","article-title":"Posttranslational modifications of mitochondrial fission and fusion proteins in cardiac physiology and pathophysiology","volume":"316","author":"Adaniya","year":"2019","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"2022032308470118100_B31","doi-asserted-by":"publisher","first-page":"517","DOI":"10.3389\/fphys.2019.00517","article-title":"Mitofusins: disease gatekeepers and hubs in mitochondrial quality control by E3 ligases","volume":"10","author":"Escobar-Henriques","year":"2019","journal-title":"Front. Physiol."},{"key":"2022032308470118100_B32","doi-asserted-by":"publisher","first-page":"4861","DOI":"10.1093\/hmg\/ddq419","article-title":"Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1\/parkin-dependent manner upon induction of mitophagy","volume":"19","author":"Gegg","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"2022032308470118100_B33","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1126\/science.1231031","article-title":"PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria","volume":"340","author":"Chen","year":"2013","journal-title":"Science"},{"key":"2022032308470118100_B34","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1083\/jcb.200611064","article-title":"The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division","volume":"178","author":"Karbowski","year":"2007","journal-title":"J. Cell Biol."},{"key":"2022032308470118100_B35","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.molcel.2015.02.021","article-title":"Extracellular regulated kinase phosphorylates mitofusin 1 to control mitochondrial morphology and apoptosis","volume":"58","author":"Pyakurel","year":"2015","journal-title":"Mol. Cell"},{"key":"2022032308470118100_B36","doi-asserted-by":"publisher","first-page":"4177","DOI":"10.1111\/febs.14122","article-title":"Control of cell death and mitochondrial fission by ERK1\/2 MAP kinase signalling","volume":"284","author":"Cook","year":"2017","journal-title":"FEBS J."},{"key":"2022032308470118100_B37","doi-asserted-by":"publisher","first-page":"6535","DOI":"10.1242\/jcs.01565","article-title":"Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity","volume":"117","author":"Ishihara","year":"2004","journal-title":"J. Cell Sci."},{"key":"2022032308470118100_B38","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.1242\/jcs.00479","article-title":"Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells","volume":"116","author":"Santel","year":"2003","journal-title":"J. Cell Sci."},{"key":"2022032308470118100_B39","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/nature07534","article-title":"Mitofusin 2 tethers endoplasmic reticulum to mitochondria","volume":"456","author":"de Brito","year":"2008","journal-title":"Nature"},{"key":"2022032308470118100_B40","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/j.cell.2007.06.026","article-title":"Mitochondrial fusion protects against neurodegeneration in the cerebellum","volume":"130","author":"Chen","year":"2007","journal-title":"Cell"},{"key":"2022032308470118100_B41","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/s41419-017-0023-6","article-title":"Mitofusin 2: from functions to disease","volume":"9","author":"Filadi","year":"2018","journal-title":"Cell Death Dis."},{"key":"2022032308470118100_B42","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1126\/science.1207385","article-title":"ER tubules mark sites of mitochondrial division","volume":"334","author":"Friedman","year":"2011","journal-title":"Science"},{"key":"2022032308470118100_B43","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1083\/jcb.201308006","article-title":"The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission","volume":"204","author":"Anand","year":"2014","journal-title":"J. Cell Biol."},{"key":"2022032308470118100_B44","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1083\/jcb.201507022","article-title":"Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria","volume":"212","author":"Korwitz","year":"2016","journal-title":"J. Cell Biol."},{"key":"2022032308470118100_B45","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/nsmb.1949","article-title":"Conformational changes in Dnm1 support a contractile mechanism for mitochondrial fission","volume":"18","author":"Mears","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2022032308470118100_B46","doi-asserted-by":"publisher","first-page":"8233","DOI":"10.1523\/JNEUROSCI.0649-18.2018","article-title":"AKAP1 protects from cerebral ischemic stroke by inhibiting Drp1-dependent mitochondrial fission","volume":"38","author":"Flippo","year":"2018","journal-title":"J. Neurosci."},{"key":"2022032308470118100_B47","doi-asserted-by":"publisher","first-page":"114874","DOI":"10.1016\/j.taap.2019.114874","article-title":"p38 MAPK-DRP1 signaling is involved in mitochondrial dysfunction and cell death in mutant A53T alpha-synuclein model of Parkinson's disease","volume":"388","author":"Gui","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"2022032308470118100_B48","doi-asserted-by":"publisher","first-page":"e3117","DOI":"10.1038\/cddis.2017.524","article-title":"c-Abl-mediated Drp1 phosphorylation promotes oxidative stress-induced mitochondrial fragmentation and neuronal cell death","volume":"8","author":"Zhou","year":"2017","journal-title":"Cell Death Dis."},{"key":"2022032308470118100_B49","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1210\/me.2013-1109","article-title":"AMPK regulates ER morphology and function in stressed pancreatic beta-cells via phosphorylation of DRP1","volume":"27","author":"Wikstrom","year":"2013","journal-title":"Mol. Endocrinol."},{"key":"2022032308470118100_B50","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1161\/CIRCRESAHA.117.311307","article-title":"Mitochondrial reactive oxygen species in lipotoxic hearts induce post-translational modifications of AKAP121, DRP1, and OPA1 that promote mitochondrial fission","volume":"122","author":"Tsushima","year":"2018","journal-title":"Circ. Res."},{"key":"2022032308470118100_B51","doi-asserted-by":"publisher","first-page":"21583","DOI":"10.1074\/jbc.C700083200","article-title":"Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology","volume":"282","author":"Chang","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2022032308470118100_B52","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/j.cmet.2015.08.022","article-title":"Calcineurin links mitochondrial elongation with energy metabolism","volume":"22","author":"Pfluger","year":"2015","journal-title":"Cell Metab."},{"key":"2022032308470118100_B53","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1038\/sj.embor.7401062","article-title":"Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death","volume":"8","author":"Cribbs","year":"2007","journal-title":"EMBO Rep."},{"key":"2022032308470118100_B54","doi-asserted-by":"publisher","first-page":"e1000612","DOI":"10.1371\/journal.pbio.1000612","article-title":"Mechanism of neuroprotective mitochondrial remodeling by PKA\/AKAP1","volume":"9","author":"Merrill","year":"2011","journal-title":"PLoS Biol."},{"key":"2022032308470118100_B55","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1016\/j.bbabio.2016.03.016","article-title":"DRP1-dependent apoptotic mitochondrial fission occurs independently of BAX, BAK and APAF1 to amplify cell death by BID and oxidative stress","volume":"1857","author":"Oettinghaus","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"2022032308470118100_B56","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/embor.2011.54","article-title":"MiD49 and MiD51, new components of the mitochondrial fission machinery","volume":"12","author":"Palmer","year":"2011","journal-title":"EMBO Rep."},{"key":"2022032308470118100_B57","doi-asserted-by":"publisher","first-page":"27584","DOI":"10.1074\/jbc.M113.479873","article-title":"Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission","volume":"288","author":"Palmer","year":"2013","journal-title":"J. Biol. Chem."},{"key":"2022032308470118100_B58","doi-asserted-by":"publisher","first-page":"2953","DOI":"10.1242\/jcs.199562","article-title":"The constriction and scission machineries involved in mitochondrial fission","volume":"130","author":"Kraus","year":"2017","journal-title":"J. Cell Sci."},{"key":"2022032308470118100_B59","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1126\/science.aab4138","article-title":"AMP-activated protein kinase mediates mitochondrial fission in response to energy stress","volume":"351","author":"Toyama","year":"2016","journal-title":"Science"},{"key":"2022032308470118100_B60","doi-asserted-by":"publisher","first-page":"6284","DOI":"10.1096\/fj.201903051R","article-title":"AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1-Parkin independent manner","volume":"34","author":"Seabright","year":"2020","journal-title":"FASEB J."},{"key":"2022032308470118100_B61","doi-asserted-by":"publisher","first-page":"e99748","DOI":"10.15252\/embj.201899748","article-title":"Human Fis1 regulates mitochondrial dynamics through inhibition of the fusion machinery","volume":"38","author":"Yu","year":"2019","journal-title":"EMBO J."},{"key":"2022032308470118100_B62","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1091\/mbc.e12-10-0721","article-title":"Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission","volume":"24","author":"Loson","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"2022032308470118100_B63","doi-asserted-by":"publisher","first-page":"2762","DOI":"10.1038\/emboj.2011.198","article-title":"Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission","volume":"30","author":"Zhao","year":"2011","journal-title":"EMBO J."},{"key":"2022032308470118100_B64","doi-asserted-by":"publisher","first-page":"467","DOI":"10.3389\/fcell.2020.00467","article-title":"Mitophagy, mitochondrial homeostasis, and cell fate","volume":"8","author":"Ma","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"2022032308470118100_B65","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrm3028","article-title":"Mechanisms of mitophagy","volume":"12","author":"Youle","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2022032308470118100_B66","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1089\/ars.2010.3799","article-title":"Targeting mitochondrial dysfunction: role for PINK1 and Parkin in mitochondrial quality control","volume":"14","author":"Narendra","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"2022032308470118100_B67","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/ncb2422","article-title":"Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells","volume":"14","author":"Liu","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"2022032308470118100_B68","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1093\/cvr\/cvn098","article-title":"Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha","volume":"79","author":"Ventura-Clapier","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"2022032308470118100_B69","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/s41586-021-03510-6","article-title":"Distinct fission signatures predict mitochondrial degradation or biogenesis","volume":"593","author":"Kleele","year":"2021","journal-title":"Nature"},{"key":"2022032308470118100_B70","doi-asserted-by":"publisher","first-page":"R170","DOI":"10.1016\/j.cub.2018.01.004","article-title":"Mitophagy and quality control mechanisms in mitochondrial maintenance","volume":"28","author":"Pickles","year":"2018","journal-title":"Curr. Biol."},{"key":"2022032308470118100_B71","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nrm.2017.129","article-title":"Building and decoding ubiquitin chains for mitophagy","volume":"19","author":"Harper","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2022032308470118100_B72","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.tem.2012.06.006","article-title":"Transcriptional integration of mitochondrial biogenesis","volume":"23","author":"Scarpulla","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"key":"2022032308470118100_B73","doi-asserted-by":"publisher","first-page":"101271","DOI":"10.1016\/j.siny.2021.101271","article-title":"Need for more evidence in the prevention and management of perinatal asphyxia and neonatal encephalopathy in low and middle-income countries: A call for action","volume":"26","author":"Krishnan","year":"2021","journal-title":"Semin. Fetal Neonatal Med."},{"key":"2022032308470118100_B74","doi-asserted-by":"publisher","first-page":"4901014","DOI":"10.1155\/2016\/4901014","article-title":"Plasticity in the neonatal brain following hypoxic-ischaemic injury","volume":"2016","author":"Rocha-Ferreira","year":"2016","journal-title":"Neural Plast."},{"key":"2022032308470118100_B75","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1542\/peds.100.6.1004","article-title":"Interventions for perinatal hypoxic\u2013ischemic encephalopathy","volume":"100","author":"Vannucci","year":"1997","journal-title":"Pediatrics"},{"key":"2022032308470118100_B76","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1523\/JNEUROSCI.21-06-01931.2001","article-title":"Delayed neurodegeneration in neonatal rat thalamus after hypoxia\u2013ischemia is apoptosis","volume":"21","author":"Northington","year":"2001","journal-title":"J. Neurosci."},{"key":"2022032308470118100_B77","doi-asserted-by":"publisher","first-page":"248","DOI":"10.3389\/fncel.2017.00248","article-title":"Cell death in the developing brain after hypoxia-ischemia","volume":"11","author":"Thornton","year":"2017","journal-title":"Front. Cell Neurosci."},{"key":"2022032308470118100_B78","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.cca.2015.01.026","article-title":"Role of mitochondria in apoptotic and necroptotic cell death in the developing brain","volume":"451","author":"Thornton","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"2022032308470118100_B79","doi-asserted-by":"publisher","first-page":"22509","DOI":"10.3390\/ijms160922509","article-title":"Mitochondrial optic atrophy (OPA) 1 processing is altered in response to neonatal hypoxic-ischemic brain injury","volume":"16","author":"Baburamani","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"2022032308470118100_B80","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/S1474-4422(12)70058-3","article-title":"Tertiary mechanisms of brain damage: a new hope for treatment of cerebral palsy?","volume":"11","author":"Fleiss","year":"2012","journal-title":"Lancet Neurol."},{"key":"2022032308470118100_B81","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.ajog.2008.06.094","article-title":"A systematic review of the role of intrapartum hypoxia-ischemia in the causation of neonatal encephalopathy","volume":"199","author":"Graham","year":"2008","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2022032308470118100_B82","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1001\/jama.2017.14972","article-title":"Effect of therapeutic hypothermia initiated after 6 hours of age on death or disability among newborns with hypoxic-ischemic encephalopathy: a randomized clinical trial","volume":"318","author":"Laptook","year":"2017","journal-title":"JAMA"},{"key":"2022032308470118100_B83","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1056\/NEJMoa1112066","article-title":"Childhood outcomes after hypothermia for neonatal encephalopathy","volume":"366","author":"Shankaran","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"2022032308470118100_B84","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"Whole-body hypothermia for neonates with hypoxic\u2013ischemic encephalopathy","volume":"353","author":"Shankaran","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"2022032308470118100_B85","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/pr.2011.30","article-title":"Seven- to eight-year follow-up of the CoolCap trial of head cooling for neonatal encephalopathy","volume":"71","author":"Guillet","year":"2012","journal-title":"Pediatr. Res."},{"key":"2022032308470118100_B86","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1056\/NEJMoa1315788","article-title":"Effects of hypothermia for perinatal asphyxia on childhood outcomes","volume":"371","author":"Azzopardi","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"2022032308470118100_B87","doi-asserted-by":"publisher","first-page":"c363","DOI":"10.1136\/bmj.c363","article-title":"Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data","volume":"340","author":"Edwards","year":"2010","journal-title":"BMJ"},{"key":"2022032308470118100_B88","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/jcbfm.2012.158","article-title":"The dynamics of the mitochondrial organelle as a potential therapeutic target","volume":"33","author":"Anne Stetler","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"2022032308470118100_B89","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1111\/j.1651-2227.1993.tb12601.x","article-title":"Excitatory amino acids in the cerebrospinal fluid of asphyxiated infants: relationship to hypoxic-ischemic encephalopathy","volume":"82","author":"Hagberg","year":"1993","journal-title":"Acta Paediatr."},{"key":"2022032308470118100_B90","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0165-3806(00)00110-3","article-title":"Subcellular distribution of calcium and ultrastructural changes after cerebral hypoxia-ischemia in immature rats","volume":"125","author":"Puka-Sundvall","year":"2000","journal-title":"Brain Res. Dev. Brain Res."},{"key":"2022032308470118100_B91","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.jneuroim.2005.06.031","article-title":"Expression of nitric oxide synthase isoforms and nitrotyrosine formation after hypoxia-ischemia in the neonatal rat brain","volume":"167","author":"van den Tweel","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"2022032308470118100_B92","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0165-3806(00)00112-7","article-title":"Alterations in glutathione and amino acid concentrations after hypoxia-ischemia in the immature rat brain","volume":"125","author":"Wallin","year":"2000","journal-title":"Brain Res. Dev. Brain Res."},{"key":"2022032308470118100_B93","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/j.neuroscience.2007.06.060","article-title":"Failure to complete apoptosis following neonatal hypoxia-ischemia manifests as \u201ccontinuum\u201d phenotype of cell death and occurs with multiple manifestations of mitochondrial dysfunction in rodent forebrain","volume":"149","author":"Northington","year":"2007","journal-title":"Neuroscience"},{"key":"2022032308470118100_B94","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1002\/(SICI)1096-9861(19970203)378:1%3c10::AID-CNE4%3e3.0.CO;2-N","article-title":"Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum","volume":"378","author":"Portera-Cailliau","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"2022032308470118100_B95","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/S1474-4422(13)70261-8","article-title":"Mitochondria: hub of injury responses in the developing brain","volume":"13","author":"Hagberg","year":"2014","journal-title":"Lancet Neurol."},{"key":"2022032308470118100_B96","doi-asserted-by":"publisher","first-page":"506320","DOI":"10.1155\/2012\/506320","article-title":"Molecular mechanisms of neonatal brain injury","volume":"2012","author":"Thornton","year":"2012","journal-title":"Neurol. Res. Int."},{"key":"2022032308470118100_B97","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1097\/00004647-199803000-00008","article-title":"Mitochondrial function and energy metabolism after hypoxia-ischemia in the immature rat brain: involvement of NMDA-receptors","volume":"18","author":"Gilland","year":"1998","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"2022032308470118100_B98","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0165-3806(00)00111-5","article-title":"Impairment of mitochondrial respiration after cerebral hypoxia-ischemia in immature rats: relationship to activation of caspase-3 and neuronal injury","volume":"125","author":"Puka-Sundvall","year":"2000","journal-title":"Brain Res. Dev. Brain Res."},{"key":"2022032308470118100_B99","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1161\/01.STR.20.5.674","article-title":"Mitochondrial function after asphyxia in newborn lambs","volume":"20","author":"Rosenberg","year":"1989","journal-title":"Stroke"},{"key":"2022032308470118100_B100","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/sj.cdd.4402053","article-title":"Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia","volume":"14","author":"Zhu","year":"2007","journal-title":"Cell Death Differ."},{"key":"2022032308470118100_B101","doi-asserted-by":"publisher","first-page":"2588","DOI":"10.1523\/JNEUROSCI.5832-08.2009","article-title":"Developmental shift of cyclophilin D contribution to hypoxic-ischemic brain injury","volume":"29","author":"Wang","year":"2009","journal-title":"J. Neurosci."},{"key":"2022032308470118100_B102","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1007\/BF03401871","article-title":"BAX contributes to apoptotic-like death following neonatal hypoxia-ischemia: evidence for distinct apoptosis pathways","volume":"7","author":"Gibson","year":"2001","journal-title":"Mol. Med."},{"key":"2022032308470118100_B103","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.1161\/STROKEAHA.110.589051","article-title":"Neuroprotective effect of Bax-inhibiting peptide on neonatal brain injury","volume":"41","author":"Wang","year":"2010","journal-title":"Stroke"},{"key":"2022032308470118100_B104","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1038\/nrneph.2017.107","article-title":"Mitochondrial energetics in the kidney","volume":"13","author":"Bhargava","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"key":"2022032308470118100_B105","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1111\/bph.15068","article-title":"The role of mitochondrial dynamics in cardiovascular diseases","volume":"178","author":"Forte","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"2022032308470118100_B106","doi-asserted-by":"publisher","first-page":"174603","DOI":"10.1016\/j.ejphar.2021.174603","article-title":"Emodin prevents renal ischemia-reperfusion injury via suppression of CAMKII\/DRP1-mediated mitochondrial fission","volume":"916","author":"Wang","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"2022032308470118100_B107","doi-asserted-by":"publisher","first-page":"e0248554","DOI":"10.1371\/journal.pone.0248554","article-title":"DRP1 haploinsufficiency attenuates cardiac ischemia\/reperfusion injuries","volume":"16","author":"Bouche","year":"2021","journal-title":"PLoS ONE"},{"key":"2022032308470118100_B108","doi-asserted-by":"publisher","first-page":"e2238","DOI":"10.1038\/cddis.2016.139","article-title":"Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction","volume":"7","author":"Hall","year":"2016","journal-title":"Cell Death Dis."},{"key":"2022032308470118100_B109","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.redox.2018.03.002","article-title":"Diverse roles of mitochondria in ischemic stroke","volume":"16","author":"Yang","year":"2018","journal-title":"Redox Biol."},{"key":"2022032308470118100_B110","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1038\/cdd.2012.18","article-title":"Inhibition of Drp1 provides neuroprotection in vitro and in vivo","volume":"19","author":"Grohm","year":"2012","journal-title":"Cell Death Differ."},{"key":"2022032308470118100_B111","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.mcn.2016.08.010","article-title":"Mitochondrial dynamics following global cerebral ischemia","volume":"76","author":"Kumar","year":"2016","journal-title":"Mol. Cell. Neurosci."},{"key":"2022032308470118100_B112","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jphs.2018.10.012","article-title":"Schaftoside ameliorates oxygen glucose deprivation-induced inflammation associated with the TLR4\/Myd88\/Drp1-related mitochondrial fission in BV2 microglia cells","volume":"139","author":"Zhou","year":"2019","journal-title":"J. Pharmacol. Sci."},{"key":"2022032308470118100_B113","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1080\/01616412.2016.1215050","article-title":"Effect of inhibiting mitochondrial fission on energy metabolism in rat hippocampal neurons during ischemia\/reperfusion injury","volume":"38","author":"Li","year":"2016","journal-title":"Neurol. Res."},{"key":"2022032308470118100_B114","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.mito.2018.12.004","article-title":"Hypoxia-reoxygenation of primary astrocytes results in a redistribution of mitochondrial size and mitophagy","volume":"47","author":"Quintana","year":"2019","journal-title":"Mitochondrion"},{"key":"2022032308470118100_B115","doi-asserted-by":"publisher","first-page":"152922","DOI":"10.1016\/j.phymed.2019.152922","article-title":"Atractylenolide III ameliorates cerebral ischemic injury and neuroinflammation associated with inhibiting JAK2\/STAT3\/Drp1-dependent mitochondrial fission in microglia","volume":"59","author":"Zhou","year":"2019","journal-title":"Phytomedicine"},{"key":"2022032308470118100_B116","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-021-08688-6","article-title":"O-GlcNAc transferase (OGT) protects cerebral neurons from death during ischemia\/reperfusion (I\/R) injury by modulating Drp1 in mice","author":"Zhao","year":"2021","journal-title":"Neuromol. Med."},{"key":"2022032308470118100_B117","doi-asserted-by":"publisher","first-page":"3119","DOI":"10.1523\/JNEUROSCI.1926-19.2020","article-title":"Deletion of a neuronal Drp1 activator protects against cerebral ischemia","volume":"40","author":"Flippo","year":"2020","journal-title":"J. Neurosci."},{"key":"2022032308470118100_B118","doi-asserted-by":"publisher","first-page":"101503","DOI":"10.1016\/j.redox.2020.101503","article-title":"Restoration of L-OPA1 alleviates acute ischemic stroke injury in rats via inhibiting neuronal apoptosis and preserving mitochondrial function","volume":"34","author":"Lai","year":"2020","journal-title":"Redox Biol."},{"key":"2022032308470118100_B119","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.neuroscience.2015.05.078","article-title":"Neuronal hypoxia disrupts mitochondrial fusion","volume":"301","author":"Sanderson","year":"2015","journal-title":"Neuroscience"},{"key":"2022032308470118100_B120","doi-asserted-by":"publisher","first-page":"e2781","DOI":"10.1038\/cddis.2017.196","article-title":"Haploinsufficiency in the mitochondrial protein CHCHD4 reduces brain injury in a mouse model of neonatal hypoxia-ischemia","volume":"8","author":"Sun","year":"2017","journal-title":"Cell Death Dis."},{"key":"2022032308470118100_B121","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.neuroscience.2016.08.026","article-title":"Sex-dependent mitophagy and neuronal death following rat neonatal hypoxia-ischemia","volume":"335","author":"Demarest","year":"2016","journal-title":"Neuroscience"},{"key":"2022032308470118100_B122","doi-asserted-by":"publisher","first-page":"709301","DOI":"10.3389\/fnsyn.2021.709301","article-title":"Current therapies for neonatal hypoxic-ischaemic and infection-sensitised hypoxic-ischaemic brain damage","volume":"13","author":"Tetorou","year":"2021","journal-title":"Front. Synapt. Neurosci."},{"key":"2022032308470118100_B123","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41392-020-00447-6","article-title":"Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity","volume":"6","author":"Zeng","year":"2021","journal-title":"Signal Transduct. Target Ther."},{"key":"2022032308470118100_B124","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1096\/fj.201901467R","article-title":"Identification of novel dynamin-related protein 1 (Drp1) GTPase inhibitors: therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia-reperfusion injury","volume":"34","author":"Wu","year":"2020","journal-title":"FASEB J."},{"key":"2022032308470118100_B125","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/nrd.2018.168","article-title":"Drug repurposing: progress, challenges and recommendations","volume":"18","author":"Pushpakom","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"2022032308470118100_B126","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s40035-020-00197-z","article-title":"Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation","volume":"9","author":"Yang","year":"2020","journal-title":"Transl. Neurodegener."},{"key":"2022032308470118100_B127","doi-asserted-by":"publisher","first-page":"e126915","DOI":"10.1172\/jci.insight.126915","article-title":"Mitochondrial fusion exploits a therapeutic vulnerability of pancreatic cancer","volume":"5","author":"Yu","year":"2019","journal-title":"JCI Insight"},{"key":"2022032308470118100_B128","doi-asserted-by":"publisher","first-page":"268e4","DOI":"10.1016\/j.chembiol.2017.12.001","article-title":"Identification of new activators of mitochondrial fusion reveals a link between mitochondrial morphology and pyrimidine metabolism","volume":"25","author":"Miret-Casals","year":"2018","journal-title":"Cell Chem. Biol."},{"key":"2022032308470118100_B129","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.chembiol.2018.02.014","article-title":"Flaming mitochondria: the anti-inflammatory drug leflunomide boosts mitofusins","volume":"25","author":"Pellattiero","year":"2018","journal-title":"Cell Chem Biol."},{"key":"2022032308470118100_B130","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s13058-020-01301-x","article-title":"Enhanced mitochondrial fission suppresses signaling and metastasis in triple-negative breast cancer","volume":"22","author":"Humphries","year":"2020","journal-title":"Breast Cancer Res."},{"key":"2022032308470118100_B131","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1111\/j.1442-2042.2006.01592.x","article-title":"Prevention of renal ischemia\/reperfusion-induced injury in rats by leflunomide","volume":"13","author":"Karaman","year":"2006","journal-title":"Int. J. Urol."},{"key":"2022032308470118100_B132","doi-asserted-by":"publisher","first-page":"R1136","DOI":"10.1152\/ajpregu.00315.2012","article-title":"Aryl hydrocarbon receptor agonist, leflunomide, protects the ischemic-reperfused kidney: role of Tregs and stem cells","volume":"303","author":"Baban","year":"2012","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2022032308470118100_B133","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s10620-009-0737-0","article-title":"Protective effects of leflunomide on intestinal ischemia-reperfusion injury: leflunomide against intestinal ischemia-reperfusion","volume":"55","author":"Yildiz","year":"2010","journal-title":"Dig. Dis. Sci."},{"key":"2022032308470118100_B134","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1007\/s00383-006-1668-x","article-title":"Protective effects of leflunomide against ischemia-reperfusion injury of the rat liver","volume":"22","author":"Karaman","year":"2006","journal-title":"Pediatr. Surg. Int."},{"key":"2022032308470118100_B135","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1742-1241.2002.tb11251.x","article-title":"Efficacy and safety of pioglitazone in type 2 diabetes: a randomised, placebo-controlled study in patients receiving stable insulin therapy","volume":"56","author":"Rosenstock","year":"2002","journal-title":"Int. J. Clin. Pract."},{"key":"2022032308470118100_B136","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.freeradbiomed.2016.06.023","article-title":"PPARgamma as a therapeutic target to rescue mitochondrial function in neurological disease","volume":"100","author":"Corona","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"2022032308470118100_B137","doi-asserted-by":"publisher","first-page":"658362","DOI":"10.3389\/fphar.2021.658362","article-title":"Pioglitazone inhibits diabetes-induced atrial mitochondrial oxidative stress and improves mitochondrial biogenesis, dynamics, and function through the PPAR-gamma\/PGC-1alpha signaling pathway","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"2022032308470118100_B138","doi-asserted-by":"publisher","first-page":"606","DOI":"10.3389\/fgene.2019.00606","article-title":"Pioglitazone improves mitochondrial organization and bioenergetics in Down syndrome cells","volume":"10","author":"Mollo","year":"2019","journal-title":"Front. Genet."},{"key":"2022032308470118100_B139","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s12929-016-0262-3","article-title":"Peroxisome proliferator-activated receptor-gamma dependent pathway reduces the phosphorylation of dynamin-related protein 1 and ameliorates hippocampal injury induced by global ischemia in rats","volume":"23","author":"Chuang","year":"2016","journal-title":"J. Biomed. Sci."},{"key":"2022032308470118100_B140","doi-asserted-by":"publisher","first-page":"6306","DOI":"10.3390\/ijms22126306","article-title":"Pioglitazone ameliorates lipopolysaccharide-induced behavioral impairment, brain inflammation, white matter injury and mitochondrial dysfunction in neonatal rats","volume":"22","author":"Yeh","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2022032308470118100_B141","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1742-2094-4-3","article-title":"Effect of pioglitazone treatment on behavioral symptoms in autistic children","volume":"4","author":"Boris","year":"2007","journal-title":"J. Neuroinflammation"},{"key":"2022032308470118100_B142","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.jpeds.2006.08.049","article-title":"Pioglitazone as adjunctive therapy in adolescents with type 1 diabetes","volume":"149","author":"Zdravkovic","year":"2006","journal-title":"J. Pediatr."},{"key":"2022032308470118100_B143","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.ejpn.2021.02.003","article-title":"Melatonin for neuroprotection in neonatal encephalopathy: A systematic review & meta-analysis of clinical trials","volume":"31","author":"Ahmed","year":"2021","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"2022032308470118100_B144","doi-asserted-by":"publisher","first-page":"e12542","DOI":"10.1111\/jpi.12542","article-title":"Melatonin attenuates myocardial ischemia-reperfusion injury via improving mitochondrial fusion\/mitophagy and activating the AMPK-OPA1 signaling pathways","volume":"66","author":"Zhang","year":"2019","journal-title":"J. Pineal Res."},{"key":"2022032308470118100_B145","doi-asserted-by":"publisher","first-page":"7299","DOI":"10.18632\/aging.103078","article-title":"Melatonin improves mitochondrial biogenesis through the AMPK\/PGC1alpha pathway to attenuate ischemia\/reperfusion-induced myocardial damage","volume":"12","author":"Qi","year":"2020","journal-title":"Aging (Albany N.Y.)"},{"key":"2022032308470118100_B146","doi-asserted-by":"publisher","first-page":"5298483","DOI":"10.1155\/2020\/5298483","article-title":"Melatonin attenuates calcium deposition from vascular smooth muscle cells by activating mitochondrial fusion and mitophagy via an AMPK\/OPA1 signaling pathway","volume":"2020","author":"Chen","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"2022032308470118100_B147","doi-asserted-by":"publisher","first-page":"2916","DOI":"10.3390\/jcm9092916","article-title":"Melatonin improves mitochondrial dynamics and function in the kidney of Zucker diabetic fatty rats","volume":"9","author":"Agil","year":"2020","journal-title":"J. Clin. Med."},{"key":"2022032308470118100_B148","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.biopha.2018.11.060","article-title":"Therapeutic effects of melatonin on cerebral ischemia reperfusion injury: Role of Yap-OPA1 signaling pathway and mitochondrial fusion","volume":"110","author":"Wei","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"2022032308470118100_B149","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/j.1600-0773.1994.tb02005.x","article-title":"Tolfenamic acid in acute and prophylactic treatment of migraine: a review","volume":"75","author":"Hansen","year":"1994","journal-title":"Pharmacol. Toxicol."},{"key":"2022032308470118100_B150","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s12576-020-00757-y","article-title":"Tolfenamic acid inhibits GSK-3beta and PP2A mediated tau hyperphosphorylation in Alzheimer\u2019s disease models","volume":"70","author":"Zhang","year":"2020","journal-title":"J. Physiol Sci."},{"key":"2022032308470118100_B151","doi-asserted-by":"publisher","first-page":"4032428","DOI":"10.1155\/2019\/4032428","article-title":"Prevention of Huntington\u2019s disease-like behavioral deficits in R6\/1 mouse by tolfenamic acid is associated with decreases in mutant huntingtin and oxidative stress","volume":"2019","author":"Liu","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"2022032308470118100_B152","doi-asserted-by":"publisher","first-page":"3631","DOI":"10.1093\/hmg\/ddaa244","article-title":"Drug repositioning as a therapeutic strategy for neurodegenerations associated with OPA1 mutations","volume":"29","author":"Aleo","year":"2021","journal-title":"Hum. Mol. Genet."},{"key":"2022032308470118100_B153","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1111\/jnc.12960","article-title":"Tolfenamic acid reduces tau and CDK5 levels: implications for dementia and tauopathies","volume":"133","author":"Adwan","year":"2015","journal-title":"J. Neurochem."}],"container-title":["Bioscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20211696\/931267\/bsr-2021-1696c.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20211696\/931267\/bsr-2021-1696c.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T05:05:22Z","timestamp":1700370322000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/bioscirep\/article\/42\/3\/BSR20211696\/231001\/Mitochondrial-dynamics-in-the-neonatal-brain-a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":153,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3,31]]}},"URL":"https:\/\/doi.org\/10.1042\/bsr20211696","relation":{},"ISSN":["0144-8463","1573-4935"],"issn-type":[{"value":"0144-8463","type":"print"},{"value":"1573-4935","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,3]]},"published":{"date-parts":[[2022,3]]},"article-number":"BSR20211696"}}