{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T23:50:57Z","timestamp":1771026657165,"version":"3.50.1"},"reference-count":67,"publisher":"Portland Press Ltd.","issue":"3","license":[{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,3,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Bacterial virulence factors are often located in their genomic islands (GIs). Helicobacter pylori, a highly diverse organism is reported to be associated with several gastrointestinal diseases like, gastritis, gastric cancer (GC), peptic ulcer, duodenal ulcer (DU) etc. A novel similarity score (Sm)-based comparative analysis with GIs of 50 H. pylori strains revealed clear idea of the various factors which promote disease progression. Two putative pathogenic GIs in some of the H. pylori strains were identified. One GI, having a putative labile enterotoxin and other dynamin-like proteins (DLPs), is predicted to increase the release of toxin by membrane vesicular formation. Another island contains a virulence-associated protein D (vapD) which is a component of a type-II toxin\u2013antitoxin system (TAs), leads to enhance the severity of the H. pylori infection. Besides the well-known virulence factors like Cytotoxin-associated gene A (CagA) and vacA, several GIs have been identified which showed to have direct or indirect impact on H. pylori clinical outcomes. One such GI, containing lipopolysaccharide (LPS) biosynthesis genes was revealed to be directly connected with disease development by inhibiting the immune response. Another collagenase-containing GI worsens ulcers by slowing down the healing process. GI consisted of fliD operon was found to be connected to flagellar assembly and biofilm production. By residing in biofilms, bacteria can avoid antibiotic therapy, resulting in chronic infection. Along with well-studied CagA and vacuolating toxin A (vacA) virulent genes, it is equally important to study these identified virulence factors for better understanding H. pylori-induced disease prognosis.<\/jats:p>","DOI":"10.1042\/bsr20212084","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T10:29:45Z","timestamp":1646735385000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparative genomics analysis of statistically significant genomic islands of <i>Helicobacter pylori<\/i> strains for better understanding the disease prognosis"],"prefix":"10.1042","volume":"42","author":[{"given":"Joyeeta","family":"Chakraborty","sequence":"first","affiliation":[{"name":"Human Genetics Unit, Indian Statistical Institute, 203 B T Road, Kolkata 700108, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4602-0838","authenticated-orcid":false,"given":"Raghunath","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Human Genetics Unit, Indian Statistical Institute, 203 B T Road, Kolkata 700108, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2022,3,16]]},"reference":[{"key":"2022031611465589800_B1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3892\/ijo.2012.1701","article-title":"H. pylori infection and gastric cancer: state of the art (review)","volume":"42","author":"Conteduca","year":"2013","journal-title":"Int. J. Oncol."},{"key":"2022031611465589800_B2","doi-asserted-by":"publisher","first-page":"3713","DOI":"10.1128\/IAI.00407-12","article-title":"Helicobacter pylori requires TlpD-driven chemotaxis to proliferate in the antrum","volume":"80","author":"Rolig","year":"2012","journal-title":"Infect. Immun."},{"key":"2022031611465589800_B3","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/nrgastro.2013.96","article-title":"Helicobacter pylori research: historical insights and future directions","volume":"10","author":"Fock","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"2022031611465589800_B4","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/S0016-5085(98)70143-X","article-title":"Helicobacter pylori infection induces gastric cancer in mongolian gerbils","volume":"115","author":"Watanabe","year":"1998","journal-title":"Gastroenterology"},{"key":"2022031611465589800_B5","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1126\/science.284.5418.1328","article-title":"Helicobacter pylori virulence and genetic geography","volume":"284","author":"Covacci","year":"1999","journal-title":"Science"},{"key":"2022031611465589800_B6","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1056\/NEJMoa001999","article-title":"Helicobacter pylori infection and the development of gastric cancer","volume":"345","author":"Uemura","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"2022031611465589800_B7","doi-asserted-by":"publisher","first-page":"496","DOI":"10.3201\/eid0605.000509","article-title":"Genomics and bacterial pathogenesis","volume":"6","author":"Weinstock","year":"2000","journal-title":"Emerg. Infect. Dis."},{"key":"2022031611465589800_B8","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1111\/j.1574-6976.2008.00136.x","article-title":"Genomic islands: tools of bacterial horizontal gene transfer and evolution","volume":"33","author":"Juhas","year":"2009","journal-title":"FEMS Microbiol. Rev."},{"key":"2022031611465589800_B9","doi-asserted-by":"publisher","first-page":"9072","DOI":"10.1073\/pnas.0915077107","article-title":"Identification of protective and broadly conserved vaccine antigens from the genome of extraintestinal pathogenic Escherichia coli","volume":"107","author":"Moriel","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2022031611465589800_B10","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1038\/nrmicro884","article-title":"Genomic islands in pathogenic and environmental microorganisms","volume":"2","author":"Dobrindt","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"key":"2022031611465589800_B11","doi-asserted-by":"publisher","first-page":"e99209","DOI":"10.1371\/journal.pone.0099209","article-title":"Resistance determinants and mobile genetic elements of an NDM-1-encoding Klebsiella pneumoniae strain","volume":"9","author":"Hudson","year":"2014","journal-title":"PLoS ONE"},{"key":"2022031611465589800_B12","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1093\/bib\/bbn017","article-title":"MEGA: a biologist-centric software for evolutionary analysis of DNA and protein sequences","volume":"9","author":"Kumar","year":"2008","journal-title":"Brief. Bioinform."},{"key":"2022031611465589800_B13","doi-asserted-by":"publisher","first-page":"D447","DOI":"10.1093\/nar\/gku1003","article-title":"STRING v10: protein-protein interaction networks, integrated over the tree of life","volume":"43","author":"Szklarczyk","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"2022031611465589800_B14","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1038\/nprot.2015.053","article-title":"The Phyre2 web portal for protein modeling, prediction and analysis","volume":"10","author":"Kelley","year":"2015","journal-title":"Nat. Protoc."},{"key":"2022031611465589800_B15","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1107\/S0907444909042073","article-title":"MolProbity: all-atom structure validation for macromolecular crystallography","volume":"66","author":"Chen","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"2022031611465589800_B16","doi-asserted-by":"publisher","first-page":"W582","DOI":"10.1093\/nar\/gkq383","article-title":"fpocket: online tools for protein ensemble pocket detection and tracking","volume":"38","author":"Schmidtke","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"2022031611465589800_B17","doi-asserted-by":"publisher","first-page":"D129","DOI":"10.1093\/nar\/gkh028","article-title":"The Catalytic Site Atlas: a resource of catalytic sites and residues identified in enzymes using structural data","volume":"32","author":"Porter","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"2022031611465589800_B18","first-page":"82","article-title":"Pymol: an open-source molecular graphics tool","volume":"40","author":"DeLano","year":"2002","journal-title":"CCP4 Newsletter on protein crystallography"},{"key":"2022031611465589800_B19","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/nprot.2016.169","article-title":"The ClusPro web server for protein-protein docking","volume":"12","author":"Kozakov","year":"2017","journal-title":"Nat. Protoc."},{"key":"2022031611465589800_B20","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1093\/bioinformatics\/bty647","article-title":"BIPSPI: a method for the prediction of partner-specific protein-protein interfaces","volume":"35","author":"Sanchez-Garcia","year":"2019","journal-title":"Bioinformatics"},{"key":"2022031611465589800_B21","first-page":"223","article-title":"PredictBias: a server for the identification of genomic and pathogenicity islands in prokaryotes","volume":"8","author":"Pundhir","year":"2008","journal-title":"In Silico Biol."},{"key":"2022031611465589800_B22","first-page":"357","article-title":"Zisland Explorer: detect genomic islands by combining homogeneity and heterogeneity properties","volume":"18","author":"Wei","year":"2017","journal-title":"Brief. Bioinform."},{"key":"2022031611465589800_B23","doi-asserted-by":"publisher","first-page":"e0146352","DOI":"10.1371\/journal.pone.0146352","article-title":"A novel method to predict genomic islands based on mean shift clustering algorithm","volume":"11","author":"de Brito","year":"2016","journal-title":"PLoS ONE"},{"key":"2022031611465589800_B24","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1186\/1471-2105-9-329","article-title":"Evaluation of genomic island predictors using a comparative genomics approach","volume":"9","author":"Langille","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"2022031611465589800_B25","doi-asserted-by":"publisher","first-page":"W30","DOI":"10.1093\/nar\/gkx343","article-title":"IslandViewer 4: expanded prediction of genomic islands for larger-scale datasets","volume":"45","author":"Bertelli","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2022031611465589800_B26","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/1471-2164-9-150","article-title":"On detection and assessment of statistical significance of genomic islands","volume":"9","author":"Chatterjee","year":"2008","journal-title":"BMC Genomics"},{"key":"2022031611465589800_B27","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1073\/pnas.96.5.1820","article-title":"Engineering of bacterial ribosomes: replacement of all seven Escherichia coli rRNA operons by a single plasmid-encoded operon","volume":"96","author":"Nomura","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2022031611465589800_B28","doi-asserted-by":"publisher","first-page":"5201","DOI":"10.1128\/JB.181.17.5201-5209.1999","article-title":"Distinct types of rRNA operons exist in the genome of the actinomycete Thermomonospora chromogena and evidence for horizontal transfer of an entire rRNA operon","volume":"181","author":"Yap","year":"1999","journal-title":"J. Bacteriol."},{"key":"2022031611465589800_B29","doi-asserted-by":"publisher","first-page":"3699","DOI":"10.1093\/nar\/gki660","article-title":"A sensitive, support-vector-machine method for the detection of horizontal gene transfers in viral, archaeal and bacterial genomes","volume":"33","author":"Tsirigos","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"2022031611465589800_B30","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1093\/nar\/gkg004","article-title":"HGT-DB: a database of putative horizontally transferred genes in prokaryotic complete genomes","volume":"31","author":"Garcia-Vallve","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"2022031611465589800_B31","doi-asserted-by":"publisher","first-page":"5212","DOI":"10.1093\/nar\/gkg699","article-title":"Isochores and tissue-specificity","volume":"31","author":"Vinogradov","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"2022031611465589800_B32","doi-asserted-by":"publisher","first-page":"e4840","DOI":"10.7717\/peerj.4840","article-title":"Divergent and convergent evolution of housekeeping genes in human-pig lineage","volume":"6","author":"Wei","year":"2018","journal-title":"PeerJ"},{"key":"2022031611465589800_B33","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1128\/jb.173.6.1920-1931.1991","article-title":"Shuttle cloning and nucleotide sequences of Helicobacter pylori genes responsible for urease activity","volume":"173","author":"Labigne","year":"1991","journal-title":"J Bacteriol."},{"key":"2022031611465589800_B34","doi-asserted-by":"publisher","first-page":"2466","DOI":"10.1128\/jb.174.8.2466-2473.1992","article-title":"Expression of Helicobacter pylori urease genes in Escherichia coil grown under nitrogen-limiting conditions","volume":"174","author":"Cussac","year":"1992","journal-title":"J Bacteriol."},{"key":"2022031611465589800_B35","doi-asserted-by":"publisher","first-page":"515","DOI":"10.3109\/00365529509089782","article-title":"Evidence of de novo collagen synthesis in healing human gastric ulcers","volume":"30","author":"Gillessen","year":"1995","journal-title":"Scand. J. Gastroenterol."},{"key":"2022031611465589800_B36","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1016\/j.apjtb.2016.10.005","article-title":"The impacts of a fliD mutation on the biofilm formation of Helicobacter pylori","volume":"6","author":"Ratthawongjirakul","year":"2016","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"2022031611465589800_B37","doi-asserted-by":"publisher","first-page":"5632","DOI":"10.3748\/wjg.v20.i19.5632","article-title":"Biofilm and Helicobacter pylori: from environment to human host","volume":"20","author":"Garcia","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"2022031611465589800_B38","doi-asserted-by":"publisher","first-page":"e1000819","DOI":"10.1371\/journal.ppat.1000819","article-title":"Helicobacter pylori lipopolysaccharide is synthesized via a novel pathway with an evolutionary connection to protein N-glycosylation","volume":"6","author":"Hug","year":"2010","journal-title":"PLoS Pathog."},{"key":"2022031611465589800_B39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1349-7006.2005.00006.x","article-title":"Salt, salted food intake, and risk of gastric cancer: epidemiologic evidence","volume":"96","author":"Tsugane","year":"2005","journal-title":"Cancer Sci."},{"key":"2022031611465589800_B40","first-page":"942","article-title":"Helicobacter pylori-associated gastric cancer in INS-GAS mice is gender specific","volume":"63","author":"Fox","year":"2003","journal-title":"Cancer Res."},{"key":"2022031611465589800_B41","first-page":"4823","article-title":"High-salt diet induces gastric epithelial hyperplasia and parietal cell loss, and enhances Helicobacter pylori colonization in C57BL\/6 mice","volume":"59","author":"Fox","year":"1999","journal-title":"Cancer Res."},{"key":"2022031611465589800_B42","doi-asserted-by":"publisher","first-page":"482","DOI":"10.4161\/gmic.26262","article-title":"Diet, microbial virulence, and Helicobacter pylori-induced gastric cancer","volume":"4","author":"Cover","year":"2013","journal-title":"Gut Microbes."},{"key":"2022031611465589800_B43","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1002\/prca.201400176","article-title":"Alteration of the Helicobacter pylori membrane proteome in response to changes in environmental salt concentration","volume":"9","author":"Voss","year":"2015","journal-title":"Proteomics Clin. Appl."},{"key":"2022031611465589800_B44","doi-asserted-by":"publisher","first-page":"2524","DOI":"10.1128\/AAC.48.7.2524-2530.2004","article-title":"Molecular characterization of benzimidazole resistance in Helicobacter pylori","volume":"48","author":"Mills","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"2022031611465589800_B45","doi-asserted-by":"publisher","first-page":"e1006464","DOI":"10.1371\/journal.ppat.1006464","article-title":"Helicobacter pylori gene silencing in vivo demonstrates urease is essential for chronic infection","volume":"13","author":"Debowski","year":"2017","journal-title":"PLoS Pathog."},{"key":"2022031611465589800_B46","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1172\/JCI9351","article-title":"Local pH elevation mediated by the intrabacterial urease of Helicobacter pylori cocultured with gastric cells","volume":"106","author":"Athmann","year":"2000","journal-title":"J. Clin. Invest."},{"key":"2022031611465589800_B47","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1126\/science.287.5452.482","article-title":"A H+-gated urea channel: the link between Helicobacter pylori urease and gastric colonization","volume":"287","author":"Weeks","year":"2000","journal-title":"Science"},{"key":"2022031611465589800_B48","doi-asserted-by":"publisher","first-page":"14648","DOI":"10.1073\/pnas.93.25.14648","article-title":"Cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors","volume":"93","author":"Censini","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2022031611465589800_B49","doi-asserted-by":"publisher","first-page":"e4754","DOI":"10.1371\/journal.pone.0004754","article-title":"Helicobacter pylori cag-Pathogenicity island-dependent early immunological response triggers later precancerous gastric changes in Mongolian gerbils","volume":"4","author":"Wiedemann","year":"2009","journal-title":"PLoS ONE"},{"key":"2022031611465589800_B50","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1084\/jem.192.11.1601","article-title":"Virulence factors of Helicobacter pylori responsible for gastric diseases in Mongolian gerbil","volume":"192","author":"Ogura","year":"2000","journal-title":"J. Exp. Med."},{"key":"2022031611465589800_B51","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1471-2180-8-14","article-title":"The human gastric pathogen Helicobacter pylori has a potential acetone carboxylase that enhances its ability to colonize mice","volume":"8","author":"Brahmachary","year":"2008","journal-title":"BMC Microbiol."},{"key":"2022031611465589800_B52","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1146\/annurev.biochem.71.110601.135414","article-title":"Lipopolysaccharide endotoxins","volume":"71","author":"Raetz","year":"2002","journal-title":"Annu. Rev. Biochem."},{"key":"2022031611465589800_B53","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1016\/j.carres.2007.12.012","article-title":"Relevance of fucosylation and Lewis antigen expression in the bacterial gastroduodenal pathogen Helicobacter pylori","volume":"343","author":"Moran","year":"2008","journal-title":"Carbohydr. Res."},{"key":"2022031611465589800_B54","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1084\/jem.20041061","article-title":"Helicobacter pylori modulates the T helper cell 1\/T helper cell 2 balance through phase-variable interaction between lipopolysaccharide and DC-SIGN","volume":"200","author":"Bergman","year":"2004","journal-title":"J. Exp. Med."},{"key":"2022031611465589800_B55","doi-asserted-by":"publisher","first-page":"6969","DOI":"10.1128\/JB.181.22.6969-6976.1999","article-title":"Molecular cloning and characterization of the Helicobacter pylori fliD gene, an essential factor in flagellar structure and motility","volume":"181","author":"Kim","year":"1999","journal-title":"J. Bacteriol."},{"key":"2022031611465589800_B56","doi-asserted-by":"publisher","first-page":"200","DOI":"10.3389\/fmicb.2011.00200","article-title":"Campylobacter spp. as a foodborne pathogen: a review","volume":"2","author":"Silva","year":"2011","journal-title":"Front. Microbiol."},{"key":"2022031611465589800_B57","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jtbi.2004.11.005","article-title":"Amendments to the theory underlying Ussing chamber data of chloride ion secretion after bacterial enterotoxin exposure","volume":"234","author":"Lucas","year":"2005","journal-title":"J. Theor. Biol."},{"key":"2022031611465589800_B58","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/BF03168236","article-title":"Enterocyte chloride and water secretion into the small intestine after enterotoxin challenge: unifying hypothesis or intellectual dead end?","volume":"64","author":"Lucas","year":"2008","journal-title":"J. Physiol. Biochem."},{"key":"2022031611465589800_B59","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.3390\/toxins2082177","article-title":"Staphylococcal enterotoxins","volume":"2","author":"Pinchuk","year":"2010","journal-title":"Toxins (Basel)"},{"key":"2022031611465589800_B60","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.3390\/toxins6051471","article-title":"Staphylococcal enterotoxins in the etiopathogenesis of mucosal autoimmunity within the gastrointestinal tract","volume":"6","author":"Principato","year":"2014","journal-title":"Toxins (Basel)"},{"key":"2022031611465589800_B61","doi-asserted-by":"publisher","first-page":"e107211","DOI":"10.1371\/journal.pone.0107211","article-title":"LeoA, B and C from enterotoxigenic Escherichia coli (ETEC) are bacterial dynamins","volume":"9","author":"Michie","year":"2014","journal-title":"PLoS ONE"},{"key":"2022031611465589800_B62","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.3389\/fmicb.2016.01882","article-title":"What is the link between stringent response, endoribonuclease encoding Type II toxin-antitoxin systems and persistence?","volume":"7","author":"Ramisetty","year":"2016","journal-title":"Front. Microbiol."},{"key":"2022031611465589800_B63","doi-asserted-by":"publisher","first-page":"2852","DOI":"10.1128\/jb.179.9.2852-2856.1997","article-title":"High-level genetic diversity in the vapD chromosomal region of Helicobacter pylori","volume":"179","author":"Cao","year":"1997","journal-title":"J. Bacteriol."},{"key":"2022031611465589800_B64","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/S0923-2508(01)01217-7","article-title":"Induction of vap genes encoded by the virulence plasmid of Rhodococcus equi during acid tolerance response","volume":"152","author":"Benoit","year":"2001","journal-title":"Res. Microbiol."},{"key":"2022031611465589800_B65","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/1471-2180-4-30","article-title":"Identification and characterization of a nontypeable Haemophilus influenzae putative toxin-antitoxin locus","volume":"4","author":"Daines","year":"2004","journal-title":"BMC Microbiol."},{"key":"2022031611465589800_B66","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.3389\/fmicb.2016.01872","article-title":"Transcriptional profiling of type II toxin-antitoxin genes of Helicobacter pylori under different environmental conditions: identification of HP0967-HP0968 system","volume":"7","author":"Cardenas-Mondragon","year":"2016","journal-title":"Front. Microbiol."},{"key":"2022031611465589800_B67","doi-asserted-by":"publisher","first-page":"e0230220","DOI":"10.1371\/journal.pone.0230220","article-title":"High expression of Helicobacter pylori VapD in both the intracellular environment and biopsies from gastric patients with severity","volume":"15","author":"Morales-Espinosa","year":"2020","journal-title":"PLoS ONE"}],"container-title":["Bioscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20212084\/931063\/bsr-2021-2084.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20212084\/931063\/bsr-2021-2084.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T11:48:13Z","timestamp":1647431293000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/bioscirep\/article\/42\/3\/BSR20212084\/230988\/Comparative-genomics-analysis-of-statistically"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":67,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3,31]]}},"URL":"https:\/\/doi.org\/10.1042\/bsr20212084","relation":{},"ISSN":["0144-8463","1573-4935"],"issn-type":[{"value":"0144-8463","type":"print"},{"value":"1573-4935","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,3]]},"published":{"date-parts":[[2022,3]]},"article-number":"BSR20212084"}}