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In early stage, PWS is characterized by respiratory distress, hypotonia, and poor sucking ability, causing feeding concern and poor weight gain. Additional features of the disease evolve over time. These include hyperphagia, obesity, developmental, cognitive delay, skin picking, high pain threshold, short stature, growth hormone deficiency, hypogonadism, strabismus, scoliosis, joint laxity, or hip dysplasia. The disease is associated with a shortened life expectancy. There is no cure for PWS, although interventions are available for symptoms management. PWS is caused by genetic defects in chromosome 15q11.2-q13, and categorized into three groups, namely Paternal deletion, Maternal uniparental disomy, and Imprinting defect. PWS is confirmed through genetic testing and DNA-methylation analysis. Studies revealed that at least two key proteins namely MAGEL-2 and NECDIN along with two proteases PCSK1 and PCSK2 are linked to PWS. Herein, we summarize our current understanding and knowledge about the role of these proteins and enzymes in various biological processes associated with PWS. The review also describes how loss and\/or impairment of functional activity of these macromolecules can lead to hormonal disbalance by promoting degradation of secretory granules and via inhibition of proteolytic maturation of precursor-proteins. The present review will draw attention of researchers, scientists, and academicians engaged in PWS study and will help to identify potential targets and molecular pathways for PWS intervention and treatment.<\/jats:p>","DOI":"10.1042\/bsr20220610","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T13:22:30Z","timestamp":1653657750000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Proteins and proteases of Prader\u2013Willi syndrome: a comprehensive review and perspectives"],"prefix":"10.1042","volume":"42","author":[{"given":"Sanjukta","family":"Basak","sequence":"first","affiliation":[{"name":"1Department of Pediatric Endocrinology, The Hospital for Sick Children, University of Toronto, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8092-2862","authenticated-orcid":false,"given":"Ajoy","family":"Basak","sequence":"additional","affiliation":[{"name":"2Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada"},{"name":"3Department of Chronic Diseases, Ottawa Hospital Research Institute, The Ottawa Hospital, University of Ottawa, Ottawa, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2022,6,17]]},"reference":[{"key":"2022061714025625200_B1","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1210\/edrv.22.6.0447","article-title":"Endocrine dysfunction in Prader-Willi syndrome: a review with special reference to GH","volume":"22","author":"Burman","year":"2001","journal-title":"Endocr. 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