{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:28:26Z","timestamp":1787318906804,"version":"build-2736575974"},"reference-count":51,"publisher":"Portland Press Ltd.","issue":"7","license":[{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The present study aimed to develop a novel methodology for controlling the mosquito larvae using different nanoparticles, with special reference to their effect on rats (a non-target mammalian model). The mosquito species of Culex quinquefasciatus was reared in the laboratory. Chitosan, silver nanoparticles and their combination as well as lavender (Lavandula officinalis) nanoemulsion with different concentrations were tested as biological insecticides against the mosquito larvae. Mammalian toxicity of the used nanoparticles were evaluated using 27 adult male rats, experimental rats were divided into 9 equal groups (n=3). The nanoparticles were added to the drinking water for 30 days. At the end of the study, blood and tissue samples were collected to assess the levels of the serum alanine aminotransferase and aspartate aminotransferase, different genes expression as interleukin 6 (IL-6) and IL-1\u03b2 activity. Histopathological and immunohistochemical studies using two markers (TNF-\u03b1 and BAX expression) were also applied. The LC50 and LC90 were recorded for each tested nanoparticles, and also the changes of the treated mosquito larvae cuticle were assessed using the scanning electron microscopy. Green nanoemulsion (Lavandula officinalis) was more effective than metal (silver) or even biodegradable (chitosan) nanoparticles in controlling of Culex quiquefasciatus mosquito larvae, and also it proved its safety by evaluation of the mammalian hepatotoxicity of the tested nanoparticles.<\/jats:p>","DOI":"10.1042\/bsr20220630","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T04:37:07Z","timestamp":1657687027000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Insecticidal efficacy of nanomaterials used to control mosquito, Culex quinquefasciatus Say, 1823 with special reference to their hepatotoxicity in rats"],"prefix":"10.1042","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9158-4229","authenticated-orcid":false,"given":"Muhammad\u00a0S.M.","family":"Shamseldean","sequence":"first","affiliation":[{"name":"1Department of Zoology and Agricultural Nematology, Faculty of Agriculture, Cairo University, Giza 12613, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa\u00a0M.","family":"Attia","sequence":"additional","affiliation":[{"name":"2Department of Parasitology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2169-0317","authenticated-orcid":false,"given":"Reda\u00a0M.S.","family":"Korany","sequence":"additional","affiliation":[{"name":"3Department of Pathology; Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehal\u00a0A.","family":"Othamn","sequence":"additional","affiliation":[{"name":"1Department of Zoology and Agricultural Nematology, Faculty of Agriculture, Cairo University, Giza 12613, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally\u00a0F.M.","family":"Allam","sequence":"additional","affiliation":[{"name":"1Department of Zoology and Agricultural Nematology, Faculty of Agriculture, Cairo University, Giza 12613, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"2022072707255011300_B1","article-title":"Update on the dengue situation in the western pacific region","author":"WHO","year":"2017"},{"key":"2022072707255011300_B2","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.14202\/vetworld.2017.1046-1051","article-title":"Hydrophilic nanosilica as a new larvicidal and molluscicidal agent for controlling of major infectious diseases in Egypt","volume":"10","author":"Attia","year":"2017","journal-title":"Veterinary World"},{"key":"2022072707255011300_B3","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.actatropica.2017.06.028","article-title":"Current vector control challenges in the fight against malaria","volume":"174","author":"Benelli","year":"2017","journal-title":"Acta Trop."},{"key":"2022072707255011300_B4","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1002\/ps.4088","article-title":"A renaissance for botanical insecticides?","volume":"71","author":"Isman","year":"2015","journal-title":"Pest Manag. 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