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This review summarizes current information about the essential biological RSS, including H2S, low molecular weight persulfides, protein persulfides as well as organic and inorganic polysulfides, their synthesis, catabolism and chemical reactivity. Moreover, the role of RSS disturbances in various pathologies including vascular diseases, chronic kidney diseases, diabetes mellitus Type 2, neurological diseases, obesity, chronic obstructive pulmonary disease and in the most current problem of COVID-19 is presented. The significance of RSS in aging is also mentioned. Finally, the possibilities of using the precursors of various forms of RSS for therapeutic purposes are discussed.<\/jats:p>","DOI":"10.1042\/bsr20221006","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T06:29:50Z","timestamp":1661840990000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Reactive sulfur species and their significance in health and disease"],"prefix":"10.1042","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0422-0428","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Iciek","sequence":"first","affiliation":[{"name":"Chair of Medical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kopernika 7, 31-034 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9066-6292","authenticated-orcid":false,"given":"Anna","family":"Bilska-Wilkosz","sequence":"additional","affiliation":[{"name":"Chair of Medical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kopernika 7, 31-034 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Kozdrowicki","sequence":"additional","affiliation":[{"name":"Chair of Medical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kopernika 7, 31-034 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6393-9977","authenticated-orcid":false,"given":"Magdalena","family":"G\u00f3rny","sequence":"additional","affiliation":[{"name":"Chair of Medical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kopernika 7, 31-034 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"2022091407383178300_B1","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1039\/c2np20009k","article-title":"Structural biology of plant sulfur metabolism: from assimilation to biosynthesis","volume":"29","author":"Ravilious","year":"2012","journal-title":"Nat. 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