{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:56:40Z","timestamp":1790200600565,"version":"4.1.0"},"reference-count":48,"publisher":"Portland Press Ltd.","issue":"9","license":[{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background: Chronic obstructive pulmonary disease (COPD) is often accompanied by intestinal symptoms. Myeloid-derived suppressor cells (MDSCs) possess immunosuppressive ability in cancer, chronic inflammation, and infection. The aim of this study was to verify the distribution of MDSCs in emphysema mouse model and participation in lung\u2013gut cross-talk.<\/jats:p>\n               <jats:p>Methods: Adult male C57BL\/6 mice were exposed to cigarette smoke (CS) for 6 months or injected with porcine pancreas elastase to establish emphysema models. Flow cytometry and immunohistochemistry analysis revealed the distribution of MDSCs in tissues. The expression of inflammation and MDSCs-associated genes in the small intestine and colon were analyzed by real-time PCR.<\/jats:p>\n               <jats:p>Results: The small intestine and colon of CS-induced emphysematous mice displayed pathological changes, CD4+\/CD8+ T cells imbalance, and increased neutrophils, monocytes, and macrophages infiltration. A significant expansion of MDSCs could be seen in CS-affected respiratory and gastrointestinal tract. Importantly, higher expression of MDSCs-related effector molecules inducible nitric oxide synthase (INOS), NADPH oxidase 2 (NOX2), and arginase 1 (ARG-1) suggested the immunosuppressive effect of migrated MDSCs (P&amp;lt;0.05).<\/jats:p>\n               <jats:p>Conclusion: These data provide evidence for lung\u2013gut axis in emphysema model and the participants of MDSCs.<\/jats:p>","DOI":"10.1042\/bsr20221041","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T09:10:07Z","timestamp":1662109807000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Gr1+ myeloid-derived suppressor cells participate in the regulation of lung\u2013gut axis during mouse emphysema model"],"prefix":"10.1042","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9364-9084","authenticated-orcid":false,"given":"Jing","family":"Yang","sequence":"first","affiliation":[{"name":"1Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine, Tianjin Nankai Hospital, Tianjin 300100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Zeng","sequence":"additional","affiliation":[{"name":"2Department of Immunology, Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaini","family":"Yang","sequence":"additional","affiliation":[{"name":"2Department of Immunology, Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Guan","sequence":"additional","affiliation":[{"name":"1Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine, Tianjin Nankai Hospital, Tianjin 300100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoying","family":"Gao","sequence":"additional","affiliation":[{"name":"1Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine, Tianjin Nankai Hospital, Tianjin 300100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simeng","family":"He","sequence":"additional","affiliation":[{"name":"3Department of Anesthesiology and Critical Care Medicine, Tianjin Nankai Hospital, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Wu","sequence":"additional","affiliation":[{"name":"3Department of Anesthesiology and Critical Care Medicine, Tianjin Nankai Hospital, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixiu","family":"Ge","sequence":"additional","affiliation":[{"name":"4Department of Clinical Laboratory, Tianjin Nankai Hospital, Tianjin 300100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Bai","sequence":"additional","affiliation":[{"name":"2Department of Immunology, Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"2022092110001508200_B1","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1016\/S0140-6736(17)31222-9","article-title":"Chronic obstructive pulmonary disease","volume":"389","author":"Rabe","year":"2017","journal-title":"Lancet"},{"key":"2022092110001508200_B2","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1056\/NEJMoa032158","article-title":"The nature of small-airway obstruction in chronic obstructive pulmonary disease","volume":"350","author":"Hogg","year":"2004","journal-title":"N. 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