{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:31:29Z","timestamp":1790019089155,"version":"4.0.1"},"reference-count":76,"publisher":"Portland Press Ltd.","issue":"10","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"DBT- NER","award":["BT\/PR25369\/NER\/95\/1162\/2017"],"award-info":[{"award-number":["BT\/PR25369\/NER\/95\/1162\/2017"]}]}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ferroptosis is a non-conventional cellular death caused by lipid peroxide induced iron deposition. Intracellular lipid accumulation followed by generation of lipid peroxides is an hallmark of non-alcoholic fatty liver disease (NAFLD). Melatonin (MLT) is an important pineal hormone with tremendous antioxidant and anti-inflammatory properties. Various studies targeted ferroptosis in different diseases using melatonin. However, none of them focused the intrinsic mechanism of MLT\u2019s action to counteract ferroptosis in NAFLD. Hence, the present study investigated the role of MLT in improvement of NAFLD-induced ferroptosis.<\/jats:p>\n                  <jats:p>HepG2 cells were treated with free fatty acids (FFAs) to induce in vitro NAFLD state and C57BL\/6 mice were fed with high-fat diet (HFD) followed by MLT administration.<\/jats:p>\n                  <jats:p>The results indicated that MLT administration caused the recovery from both FFA- and HFD-induced ferroptotic state via increasing GSH and SOD level, decreasing lipid reactive oxygen species (ROS) and malondialdehyde (MDA) level, increasing Nrf2 and HO-1 level to defend cells against an oxidative environment. MLT also altered the expression of two key proteins GPX4 and SLC7A11 back to their normal levels, which would otherwise cause ferroptosis. MLT also protected against histopathological damage of both liver tissue and HepG2 cells as depicted by Oil Red O, HE staining and immunofluorescence microscopy. MLT also had control over pAMPK\u03b1 as well as PPAR\u03b3 and PPAR\u03b1 responsible for lipid homeostasis and lipogenesis.<\/jats:p>\n                  <jats:p>In brief, MLT exerted its multifaceted effect in FFA- and HFD-induced NAFLD by retrieving cellular oxidative environment, reducing lipogenesis and lipid peroxidation and modulating Nrf2\/HO-1 and GPX4\/SLC7A11 axis to combat ferroptosis.<\/jats:p>","DOI":"10.1042\/bsr20230128","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T10:35:52Z","timestamp":1695206152000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Melatonin targets ferroptosis through bimodal alteration of redox environment and cellular pathways in NAFLD model"],"prefix":"10.1042","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6734-5044","authenticated-orcid":false,"given":"Moumita","family":"Saha","sequence":"first","affiliation":[{"name":"1Cancer Biology and Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata 700032, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjib","family":"Das","sequence":"additional","affiliation":[{"name":"1Cancer Biology and Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata 700032, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnendu","family":"Manna","sequence":"additional","affiliation":[{"name":"2Department of Food and Nutrition, University of Kalyani, CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata 700032, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9286-4986","authenticated-orcid":false,"given":"Krishna\u00a0Das","family":"Saha","sequence":"additional","affiliation":[{"name":"1Cancer Biology and Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata 700032, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2023,10,6]]},"reference":[{"key":"2023100607112332400_B1","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.cbi.2006.11.004","article-title":"A human hepatocellular in vitro model to investigate steatosis","volume":"165","author":"G\u00f3mez-Lech\u00f3n","year":"2007","journal-title":"Chem. Biol. Interact."},{"key":"2023100607112332400_B2","first-page":"9","article-title":"Non alcoholic fatty liver disease and metabolic syndrome","volume":"13","author":"Paschos","year":"2009","journal-title":"Hippokratia"},{"key":"2023100607112332400_B3","doi-asserted-by":"publisher","first-page":"715","DOI":"10.4254\/wjh.v9.i16.715","article-title":"Non-alcoholic fatty liver disease: an expanded review","volume":"9","author":"Benedict","year":"2017","journal-title":"World J. Hepatol."},{"key":"2023100607112332400_B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s43440-019-00020-1","article-title":"New therapeutic strategies in nonalcoholic fatty liver disease: a focus on promising drugs for nonalcoholic steatohepatitis","volume":"72","author":"Pydyn","year":"2020","journal-title":"Pharmacologic. Rep."},{"key":"2023100607112332400_B5","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1016\/S0016-5085(99)70506-8","article-title":"Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity\u2606, \u2606\u2606","volume":"116","author":"Matteoni","year":"1999","journal-title":"Gastroenterology"},{"key":"2023100607112332400_B6","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1111\/j.1440-1746.2008.05640.x","article-title":"Clinical features and outcomes of cirrhosis due to non-alcoholic steatohepatitis compared with cirrhosis caused by chronic hepatitis C","volume":"24","author":"Yatsuji","year":"2009","journal-title":"J. Gastroenterol. Hepatol."},{"key":"2023100607112332400_B7","doi-asserted-by":"publisher","first-page":"7352","DOI":"10.3390\/ijms15057352","article-title":"Molecular mechanisms and new treatment strategies for non-alcoholic steatohepatitis (NASH)","volume":"15","author":"Takaki","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"2023100607112332400_B8","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.15252\/emmm.201403856","article-title":"A positive feedback loop between RIP 3 and JNK controls non-alcoholic steatohepatitis","volume":"6","author":"Gautheron","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"2023100607112332400_B9","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/s41419-019-1678-y","article-title":"Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis","volume":"10","author":"Tsurusaki","year":"2019","journal-title":"Cell Death Dis."},{"key":"2023100607112332400_B10","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/modpathol.3800715","article-title":"Iron overload syndromes and the liver","volume":"20","author":"Batts","year":"2007","journal-title":"Mod. Pathol."},{"key":"2023100607112332400_B11","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/0009-2797(89)90045-8","article-title":"Hepatic injury in chronic iron overload. Role of lipid peroxidation","volume":"70","author":"Bacon","year":"1989","journal-title":"Chem. Biol. Interact."},{"key":"2023100607112332400_B12","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/s41419-020-2732-5","article-title":"The emerging role of ferroptosis in non-cancer liver diseases: hype or increasing hope?","volume":"11","author":"Mao","year":"2020","journal-title":"Cell Death Dis."},{"key":"2023100607112332400_B13","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5537330","article-title":"Ferroptosis in different pathological contexts seen through the eyes of mitochondria","volume":"2021","author":"Otasevic","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"2023100607112332400_B14","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/s41419-022-04628-9","article-title":"Targeting ferroptosis in acute kidney injury","volume":"13","author":"Ni","year":"2022","journal-title":"Cell Death Dis."},{"key":"2023100607112332400_B15","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ."},{"key":"2023100607112332400_B16","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"key":"2023100607112332400_B17","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s00726-011-0867-5","article-title":"The oxidative stress-inducible cystine\/glutamate antiporter, system x c-: Cystine supplier and beyond","volume":"42","author":"Conrad","year":"2012","journal-title":"Amino Acids"},{"key":"2023100607112332400_B18","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1046\/j.1365-2826.2003.00989.x","article-title":"Role of melatonin in the regulation of human circadian rhythms and sleep","volume":"15","author":"Cajochen","year":"2003","journal-title":"J. Neuroendocrinol."},{"key":"2023100607112332400_B19","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1159\/000148191","article-title":"Immunomodulation by melatonin: its significance for seasonally occurring diseases","volume":"15","author":"Srinivasan","year":"2008","journal-title":"NeuroImmunoModulation"},{"issue":"2","key":"2023100607112332400_B20","doi-asserted-by":"publisher","first-page":"e12584","DOI":"10.1111\/jpi.12548","article-title":"Melatonin: another avenue for treating osteoporosis?","volume":"66","author":"Li","year":"2019","journal-title":"J. Pineal Res."},{"key":"2023100607112332400_B21","doi-asserted-by":"publisher","first-page":"366","DOI":"10.3389\/fphys.2020.00366","article-title":"Cardioprotective role of melatonin in acute myocardial infarction","volume":"11","author":"Fu","year":"2020","journal-title":"Front. Physiol."},{"key":"2023100607112332400_B22","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1096\/fasebj.10.8.8666166","article-title":"Neuroproteetion by melatonin from kamate-induced excitotoxicity in rats","volume":"10","author":"Giusti","year":"1996","journal-title":"FASEB J."},{"key":"2023100607112332400_B23","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s11154-009-9117-5","article-title":"Role of melatonin in metabolic regulation","volume":"10","author":"Korkmaz","year":"2009","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"2023100607112332400_B24","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.brainresbull.2020.07.011","article-title":"Melatonin improves hypoxic-ischemic brain damage through the Akt\/Nrf2\/Gpx4 signaling pathway","volume":"163","author":"Gou","year":"2020","journal-title":"Brain Res. Bull."},{"key":"2023100607112332400_B25","doi-asserted-by":"publisher","first-page":"3652","DOI":"10.1002\/jnr.21436","article-title":"Melatonin prevents brain oxidative stress induced by obstructive jaundice in rats","volume":"85","author":"Cruz","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"2023100607112332400_B26","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S0891-5849(01)00753-5","article-title":"Original contribution melatonin reduces oxidative damage and increases survival of mice infected with schistosoma mansoni","volume":"32","author":"El-Sokkary","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"2023100607112332400_B27","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/j.bbagen.2014.11.021","article-title":"Nrf2 regulates ROS production by mitochondria and NADPH oxidase","volume":"1850","author":"Kovac","year":"2015","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"2023100607112332400_B28","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.bbadis.2016.11.005","article-title":"Nrf2 signaling pathway: pivotal roles in inflammation","volume":"1863","author":"Ahmed","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"2023100607112332400_B29","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1016\/j.jnutbio.2012.03.005","article-title":"The Nrf2-antioxidant response element pathway: a target for regulating energy metabolism","volume":"23","author":"Vomhof-DeKrey","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"2023100607112332400_B30","doi-asserted-by":"publisher","first-page":"BSR20181614","DOI":"10.1042\/BSR20181614","article-title":"Melatonin attenuates acute kidney ischemia\/reperfusion injury in diabetic rats by activation of the SIRT1\/Nrf2\/HO-1 signaling pathway","volume":"39","author":"Shi","year":"2019","journal-title":"Biosci. Rep."},{"key":"2023100607112332400_B31","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1111\/j.1600-079X.2012.00978.x","article-title":"Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model","volume":"53","author":"Wang","year":"2012","journal-title":"J. Pineal Res."},{"issue":"1","key":"2023100607112332400_B32","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1002\/hep.28251","article-title":"Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells","volume":"63","author":"Sun","year":"2016","journal-title":"Hepatology."},{"key":"2023100607112332400_B33","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.freeradbiomed.2018.10.426","article-title":"Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer","volume":"129","author":"Shin","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"2023100607112332400_B34","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1093\/embo-reports\/kve071","article-title":"Mechanisms of nutritional and hormonal regulation of lipogenesis","volume":"2","author":"Kersten","year":"2001","journal-title":"EMBO Rep."},{"key":"2023100607112332400_B35","doi-asserted-by":"publisher","first-page":"13163","DOI":"10.1073\/pnas.1411571111","article-title":"Ghrelin promotes hepatic lipogenesis by activation of mTOR-PPAR\u03b3 signaling pathway","volume":"111","author":"Li","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2023100607112332400_B36","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1194\/jlr.M015263","article-title":"Role of the AMPK\/SREBP-1 pathway in the development of orotic acid-induced fatty liver","volume":"52","author":"Jung","year":"2011","journal-title":"J. Lipid Res."},{"key":"2023100607112332400_B37","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1194\/jlr.M400261-JLR200","article-title":"Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues","volume":"46","author":"Gosmain","year":"2005","journal-title":"J. Lipid Res."},{"key":"2023100607112332400_B38","doi-asserted-by":"publisher","first-page":"748","DOI":"10.3390\/nu11040748","article-title":"Melatonin improves fatty liver syndrome by inhibiting the lipogenesis pathway in hamsters with high-fat diet-induced hyperlipidemia","volume":"11","author":"Ou","year":"2019","journal-title":"Nutrients"},{"key":"2023100607112332400_B39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/9067610","article-title":"Melatonin suppresses ferroptosis induced by high glucose via activation of the Nrf2\/HO-1 signaling pathway in Type 2 diabetic osteoporosis","volume":"2020","author":"Ma","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"2023100607112332400_B40","doi-asserted-by":"publisher","first-page":"e21803","DOI":"10.1096\/fj.202002556RRR","article-title":"Melatonin induces Nrf2-HO-1 reprogramming and corrections in hepatic core clock oscillations in Non-alcoholic fatty liver disease","volume":"35","author":"Joshi","year":"2021","journal-title":"FASEB J."},{"key":"2023100607112332400_B41","doi-asserted-by":"publisher","first-page":"163","DOI":"10.3389\/fmolb.2020.00163","article-title":"Melatonin inhibits oxidative stress and apoptosis in cryopreserved ovarian tissues via Nrf2\/HO-1 signaling pathway","volume":"7","author":"Sun","year":"2020","journal-title":"Front Mol. Biosci."},{"key":"2023100607112332400_B42","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/978-1-4939-2074-7_5","article-title":"culture and functional characterization of human hepatoma HepG2 cells","volume":"1250","author":"Donato","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"2023100607112332400_B43","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1080\/10715760400022145","article-title":"Analysis of dichlorodihydrofluorescein and dihydrocalcein as probes for the detection of intracellular reactive oxygen species","volume":"38","author":"Keller","year":"2004","journal-title":"Free Radic. Res."},{"key":"2023100607112332400_B44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/antiox9121283","article-title":"N-acetyl cysteine targets hepatic lipid accumulation to curb oxidative stress and inflammation in nafld: A comprehensive analysis of the literature","volume":"9","author":"Dludla","year":"2020","journal-title":"Antioxidants"},{"key":"2023100607112332400_B45","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/s41420-021-00660-4","article-title":"Ferroptosis in liver disease: new insights into disease mechanisms","volume":"7","author":"Wu","year":"2021","journal-title":"Cell Death Discov."},{"key":"2023100607112332400_B46","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-016-0370-9","article-title":"Melatonin improves non-alcoholic fatty liver disease via MAPK-JNK\/P38 signaling in high-fat-diet-induced obese mice","volume":"15","author":"Sun","year":"2016","journal-title":"Lipids Health Dis."},{"key":"2023100607112332400_B47","doi-asserted-by":"publisher","first-page":"4015","DOI":"10.1002\/jcp.26209","article-title":"Melatonin application in targeting oxidative-induced liver injuries: a review","volume":"233","author":"Mortezaee","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"2023100607112332400_B48","doi-asserted-by":"publisher","first-page":"826","DOI":"10.3892\/or.2019.7189","article-title":"Sulfasalazine-induced ferroptosis in breast cancer cells is reduced by the inhibitory effect of estrogen receptor on the transferrin receptor","volume":"42","author":"Yu","year":"2019","journal-title":"Oncol. Rep."},{"key":"2023100607112332400_B49","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.mehy.2017.02.017","article-title":"Iron accumulation, glutathione depletion, and lipid peroxidation must occur simultaneously during ferroptosis and are mutually amplifying events","volume":"101","author":"Bertrand","year":"2017","journal-title":"Med. Hypotheses"},{"key":"2023100607112332400_B50","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of Nrf2 in oxidative stress and toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"2023100607112332400_B51","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/S0304-4165(98)00099-3","article-title":"Scavenging of reactive oxygen species by melatonin","volume":"1425","author":"Zang","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"2023100607112332400_B52","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.bbamcr.2018.02.010","article-title":"Nrf2-Keap1 signaling in oxidative and reductive stress","volume":"1865","author":"Bellezza","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell. Res."},{"key":"2023100607112332400_B53","doi-asserted-by":"publisher","first-page":"354.e3","DOI":"10.1016\/j.molcel.2018.10.042","article-title":"Role of mitochondria in ferroptosis","volume":"73","author":"Gao","year":"2019","journal-title":"Mol. Cell."},{"issue":"5","key":"2023100607112332400_B54","doi-asserted-by":"publisher","first-page":"163","DOI":"10.20455\/ros.2016.865","article-title":"MitoSOX-based flow cytometry for detecting mitochondrial ROS","volume":"2","author":"Kauffman","year":"2016","journal-title":"Reactive Oxygen Species"},{"key":"2023100607112332400_B55","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","article-title":"Ferroptosis: death by lipid peroxidation","volume":"26","author":"Yang","year":"2016","journal-title":"Trends Cell Biol."},{"key":"2023100607112332400_B56","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.jep.2014.09.031","article-title":"Magnolia officinalis attenuates free fatty acid-induced lipogenesis via AMPK phosphorylation in hepatocytes","volume":"157","author":"Seo","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"2023100607112332400_B57","doi-asserted-by":"publisher","first-page":"236","DOI":"10.4103\/2231-4040.90879","article-title":"The peroxisome proliferator-activated receptor: A family of nuclear receptors role in various diseases","volume":"2","author":"Tyagi","year":"2011","journal-title":"J. Adv. Pharm. Technol. Res."},{"key":"2023100607112332400_B58","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.freeradbiomed.2015.10.036","article-title":"SH2 domain-containing inositol 5-phosphatase (SHIP2) inhibition ameliorates high glucose-induced de-novo lipogenesis and VLDL production through regulating AMPK\/mTOR\/SREBP1 pathway and ROS production in HepG2 cells","volume":"89","author":"Gorgani-Firuzjaee","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"2023100607112332400_B59","doi-asserted-by":"publisher","first-page":"104286","DOI":"10.1016\/j.cellimm.2021.104286","article-title":"Regulation of lipid accumulation-induced ROS in myeloid-derived suppressor cells via targeting fatty-acid transport protein 2 2 enhanced anti-PD-L1 tumor immunotherapy Running title: Targeting FATP2 in MDSCs enhanced anti-PD-L1 tumor immunotherapy","volume":"362","author":"Adeshakin","year":"2021","journal-title":"Cell. Immunol."},{"key":"2023100607112332400_B60","doi-asserted-by":"publisher","first-page":"10017","DOI":"10.18632\/oncotarget.2488","article-title":"Silibinin inhibits aberrant lipid metabolism, proliferation and emergence of androgen-independence in prostate cancer cells via primarily targeting the sterol response element binding protein 1","volume":"5","author":"Nambiar","year":"2014","journal-title":"Oncotarget"},{"key":"2023100607112332400_B61","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1111\/jcmm.13008","article-title":"Ferroptosis, a new form of cell death, and its relationships with tumourous diseases","volume":"21","author":"Yu","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"2023100607112332400_B62","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1101\/gad.314674.118","article-title":"Regulation of lipid peroxidation and ferroptosis in diverse species","volume":"32","author":"Conrad","year":"2018","journal-title":"Genes Dev."},{"key":"2023100607112332400_B63","first-page":"695","article-title":"Iron overload in patients with chronic liver disease","volume":"12","author":"Kowdley","year":"2016","journal-title":"Gastroenterol. Hepatol. (N.Y.)"},{"key":"2023100607112332400_B64","doi-asserted-by":"publisher","first-page":"708645","DOI":"10.3389\/fphar.2021.708645","article-title":"Melatonin alleviates acute sleep deprivation-induced memory loss in mice by suppressing hippocampal ferroptosis","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"2023100607112332400_B65","doi-asserted-by":"publisher","first-page":"9067610","DOI":"10.1155\/2020\/9067610","article-title":"Melatonin suppresses ferroptosis induced by high glucose via activation of the Nrf2\/HO-1 signaling pathway in type 2 diabetic osteoporosis","volume":"2020","author":"Ma","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"2023100607112332400_B66","doi-asserted-by":"publisher","first-page":"112588","DOI":"10.1016\/j.ecoenv.2021.112588","article-title":"Melatonin protects against PM2.5-induced lung injury by inhibiting ferroptosis of lung epithelial cells in a Nrf2-dependent manner","volume":"223","author":"Guohua","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"2023100607112332400_B67","doi-asserted-by":"publisher","first-page":"494","DOI":"10.3390\/nu11030494","article-title":"Lonicera caerulea extract attenuates non-alcoholic fatty liver disease in free fatty acid-induced HepG2 hepatocytes and in high fat diet-fed mice","volume":"11","author":"Park","year":"2019","journal-title":"Nutrients"},{"key":"2023100607112332400_B68","doi-asserted-by":"publisher","first-page":"339","DOI":"10.5717\/jenb.2014.18.4.339","article-title":"Effect of aerobic exercise training on non-alcoholic fatty liver disease induced by a high fat diet in C57BL\/6 mice","volume":"18","author":"Cho","year":"2014","journal-title":"J. Exerc. Nutr. Biochem."},{"key":"2023100607112332400_B69","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1089\/ars.2021.0218","article-title":"Dysregulation of iron homeostasis in the central nervous system and the role of ferroptosis in neurodegenerative disorders","volume":"37","author":"David","year":"2022","journal-title":"Antioxidants Redox Signal."},{"key":"2023100607112332400_B70","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"2023100607112332400_B71","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s40364-020-00229-w","article-title":"Novel insights on targeting ferroptosis in cancer therapy","volume":"8","author":"Zuo","year":"2020","journal-title":"Biomark Res."},{"key":"2023100607112332400_B72","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1089\/dna.2020.5730","article-title":"Lipid peroxidation, gsh depletion, and slc7a11 inhibition are common causes of emt and ferroptosis in a549 cells, but different in specific mechanisms","volume":"40","author":"Sun","year":"2021","journal-title":"DNA Cell Biol."},{"key":"2023100607112332400_B73","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/jpi.12360","article-title":"Melatonin as an antioxidant: under promises but over delivers","volume":"61","author":"Reiter","year":"2016","journal-title":"J. Pineal Res."},{"key":"2023100607112332400_B74","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1016\/j.bbagen.2017.05.019","article-title":"Ferroptosis: role of lipid peroxidation, iron and ferritinophagy","volume":"1861","author":"Latunde-Dada","year":"2017","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"2023100607112332400_B75","doi-asserted-by":"publisher","first-page":"5080843","DOI":"10.1155\/2019\/5080843","article-title":"Reactive oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis","volume":"2019","author":"Su","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"2023100607112332400_B76","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s00592-017-0976-z","article-title":"Suppression of Rho-kinase 1 is responsible for insulin regulation of the AMPK\/SREBP-1c pathway in skeletal muscle cells exposed to palmitate","volume":"54","author":"Tang","year":"2017","journal-title":"Acta Diabetol."}],"container-title":["Bioscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20230128\/950661\/bsr-2023-0128.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20230128\/950661\/bsr-2023-0128.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T03:12:30Z","timestamp":1696561950000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/bioscirep\/article\/43\/10\/BSR20230128\/233530\/Melatonin-targets-ferroptosis-through-bimodal"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":76,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10,31]]}},"URL":"https:\/\/doi.org\/10.1042\/bsr20230128","relation":{},"ISSN":["0144-8463","1573-4935"],"issn-type":[{"value":"0144-8463","type":"print"},{"value":"1573-4935","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,10]]},"published":{"date-parts":[[2023,10]]},"article-number":"BSR20230128"}}