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We analysed early pregnancy samples from a cohort of 432 first time mothers as part of the Screening for Endpoints in Pregnancy (SCOPE, European branch) project to determine the concentration of ergothioneine in their plasma. There was a weak association between the ergothioneine levels and maternal age but none for BMI. Of these 432 women, 97 went on to develop pre-term (23) or term (74) PE. If a threshold was set at the 90th percentile of the reference range in the control population (\u2265462 ng\/ml), only one of these 97 women (1%) developed PE, versus 96\/397 (24.2%) whose ergothioneine level was below this threshold. One possible interpretation of these findings, consistent with previous experiments in a reduced uterine perfusion model in rats, is that ergothioneine may indeed prove protective against PE in humans. An intervention study of some kind now seems warranted.<\/jats:p>","DOI":"10.1042\/bsr20230160","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T12:18:39Z","timestamp":1686053919000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Relationship between the concentration of ergothioneine in plasma and the likelihood of developing pre-eclampsia"],"prefix":"10.1042","volume":"43","author":[{"given":"Louise\u00a0C.","family":"Kenny","sequence":"first","affiliation":[{"name":"1Department of Women\u2019s and Children\u2019s Health, Faculty of Health and Life Sciences, University of Liverpool, Liverpool L7 8TX, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the SCOPE Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie\u00a0W.","family":"Brown","sequence":"additional","affiliation":[{"name":"2Metabolomic Diagnostics, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Ortea","sequence":"additional","affiliation":[{"name":"2Metabolomic Diagnostics, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Tuytten","sequence":"additional","affiliation":[{"name":"2Metabolomic Diagnostics, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5838-7963","authenticated-orcid":false,"given":"Douglas\u00a0B.","family":"Kell","sequence":"additional","affiliation":[{"name":"3Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Crown St, Liverpool L69 7BX, U.K."},{"name":"4Novo Nordisk Foundation Centre for Biosustainability, Technical University of Denmark, Kemitorvet 200, 2800 Kgs Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2023,7,6]]},"reference":[{"key":"2023070608575717700_B1","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.preghy.2014.01.003","article-title":"Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy","volume":"4","author":"Magee","year":"2014","journal-title":"Pregnancy Hypertens"},{"key":"2023070608575717700_B2","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/B978-0-12-407866-6.00003-1","article-title":"Epidemiology of Pregnancy-Related Hypertension","author":"Rich-Edwards","year":"2015","journal-title":"Chesley's Hypertensive Disorders in Pregnancy, 4th Edition"},{"key":"2023070608575717700_B3","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/s41581-019-0119-6","article-title":"Pre-eclampsia: pathogenesis, novel diagnostics and therapies","volume":"15","author":"Phipps","year":"2019","journal-title":"Nat. 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