{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T15:07:27Z","timestamp":1793200047362,"version":"4.5.0"},"reference-count":53,"publisher":"Portland Press Ltd.","issue":"10","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MOST | National Natural Science Foundation of China","award":["81820108031"],"award-info":[{"award-number":["81820108031"]}]},{"name":"MOST | National Natural Science Foundation of China","award":["U21A20336"],"award-info":[{"award-number":["U21A20336"]}]},{"name":"MOST | National Natural Science Foundation of China","award":["91939301"],"award-info":[{"award-number":["91939301"]}]}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cardiac remodeling serves as the underlying pathological basis for numerous cardiovascular diseases and represents a pivotal stage for intervention. The excessive activation of \u03b2-adrenergic receptors (\u03b2-ARs) assumes a crucial role in cardiac remodeling. Nonetheless, the underlying molecular mechanisms governing \u03b2-AR-induced cardiac remodeling remain largely unresolved. In the present study, we identified Src tyrosine kinase as a key player in the cardiac remodeling triggered by excessive \u03b2-AR activation. Our findings demonstrated that Src mediates isoproterenol (ISO)-induced cardiac hypertrophy, fibrosis, and inflammation in vivo. Furthermore, Src facilitates \u03b2-AR-mediated proliferation and transdifferentiation of cardiac fibroblasts, and hypertrophy and cardiomyocytes in vitro. Subsequent investigations have substantiated that Src mediates \u03b2-AR induced the extracellular signal-regulated protein kinase (ERK1\/2) signaling pathway activated by \u03b2-AR. Our research presents compelling evidence that Src promotes \u03b2-AR-induced cardiac remodeling in both in vivo and in vitro settings. It establishes the promoting effect of the \u03b2-AR\/Src\/ERK signaling pathway on overall cardiac remodeling in cardiac fibroblasts and underscores the potential of Src as a therapeutic target for cardiac remodeling.<\/jats:p>","DOI":"10.1042\/bsr20231097","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T04:40:40Z","timestamp":1693456840000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Src tyrosine kinase promotes cardiac remodeling induced by chronic sympathetic activation"],"prefix":"10.1042","volume":"43","author":[{"given":"Wenqi","family":"Li","sequence":"first","affiliation":[{"name":"1Wuxi School of Medicine, Jiangnan University, Wuxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3346-7291","authenticated-orcid":false,"given":"Yuzhong","family":"Zhu","sequence":"additional","affiliation":[{"name":"1Wuxi School of Medicine, Jiangnan University, Wuxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Wang","sequence":"additional","affiliation":[{"name":"2Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; Beijing Key Laboratory of Cardiovascular Receptors Research; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University; NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Peking University; Research Unit of Medical Science Research Management\/Basic and Clinical Research of Metabolic Cardiovascular Diseases, Chinese Academy of Medical Sciences. Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"He","sequence":"additional","affiliation":[{"name":"2Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; Beijing Key Laboratory of Cardiovascular Receptors Research; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University; NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Peking University; Research Unit of Medical Science Research Management\/Basic and Clinical Research of Metabolic Cardiovascular Diseases, Chinese Academy of Medical Sciences. Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Feng","sequence":"additional","affiliation":[{"name":"1Wuxi School of Medicine, Jiangnan University, Wuxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8057-2257","authenticated-orcid":false,"given":"Zijian","family":"Li","sequence":"additional","affiliation":[{"name":"2Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; Beijing Key Laboratory of Cardiovascular Receptors Research; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University; NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Peking University; Research Unit of Medical Science Research Management\/Basic and Clinical Research of Metabolic Cardiovascular Diseases, Chinese Academy of Medical Sciences. Beijing 100191, China"},{"name":"3Department of Pharmacy, Peking University Third Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"key":"2023102713250646700_B1","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/s41569-018-0044-6","article-title":"Metabolic remodelling in heart failure","volume":"15","author":"Bertero","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"2023102713250646700_B2","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1146\/annurev.physiol.65.092101.142243","article-title":"Cardiac hypertrophy: the good, the bad, and the ugly","volume":"65","author":"Frey","year":"2003","journal-title":"Annu. Rev. 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