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Treatment for IDA consists of replenishment of iron stores, either by oral or intravenous (IV) supplementation. There is a complex bidirectional interplay between the gut microbiota, the host\u2019s iron status, and dietary iron availability. Dietary iron deficiency and supplementation can influence the gut microbiome; however, the effect of IV iron on the gut microbiome is unknown. We studied how commonly used IV iron preparations, ferric carboxymaltose (FCM) and ferric derisomaltose (FDI), affected the gut microbiome in female iron-deficient anemic mice. At the phylum level, vehicle-treated mice showed an expansion in Verrucomicrobia, mostly because of the increased abundance of Akkermansia muciniphila, along with contraction in Firmicutes, resulting in a lower Firmicutes\/Bacteroidetes ratio (indicator of dysbiosis). Treatment with either FCM or FDI restored the microbiome such that Firmicutes and Bacteroidetes were the dominant phyla. Interestingly, the phyla Proteobacteria and several members of Bacteroidetes (e.g., Alistipes) were expanded in mice treated with FCM compared with those treated with FDI. In contrast, several Clostridia class members were expanded in mice treated with FDI compared with FCM (e.g., Dorea spp., Eubacterium). Our data demonstrate that IV iron increases gut microbiome diversity independently of the iron preparation used; however, differences exist between FCM and FDI treatments. In conclusion, replenishing iron stores with IV iron preparations in clinical conditions, such as inflammatory bowel disease or chronic kidney disease, could affect gut microbiome composition and consequently contribute to an altered disease outcome.<\/jats:p>","DOI":"10.1042\/bsr20231217","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T13:35:46Z","timestamp":1694007346000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Intravenous ferric carboxymaltose and ferric derisomaltose alter the intestinal microbiome in female iron-deficient anemic mice"],"prefix":"10.1042","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6082-662X","authenticated-orcid":false,"given":"Timo","family":"Rieg","sequence":"first","affiliation":[{"name":"1Department of Molecular Pharmacology and Physiology, Hypertension and Kidney Research Center, University of South Florida, Tampa, FL 33612, U.S.A."},{"name":"2James A. Haley Veterans\u2019 Hospital, Tampa, FL 33612, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxiang","family":"Xue","sequence":"additional","affiliation":[{"name":"1Department of Molecular Pharmacology and Physiology, Hypertension and Kidney Research Center, University of South Florida, Tampa, FL 33612, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Stevens","sequence":"additional","affiliation":[{"name":"1Department of Molecular Pharmacology and Physiology, Hypertension and Kidney Research Center, University of South Florida, Tampa, FL 33612, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linto","family":"Thomas","sequence":"additional","affiliation":[{"name":"1Department of Molecular Pharmacology and Physiology, Hypertension and Kidney Research Center, University of South Florida, Tampa, FL 33612, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James\u00a0R.","family":"White","sequence":"additional","affiliation":[{"name":"3Resphera Biosciences LLC, Baltimore, MD 21231, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6190-7464","authenticated-orcid":false,"given":"Jessica\u00a0A.","family":"Dominguez Rieg","sequence":"additional","affiliation":[{"name":"1Department of Molecular Pharmacology and Physiology, Hypertension and Kidney Research Center, University of South Florida, Tampa, FL 33612, U.S.A."},{"name":"2James A. 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