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We previously found that GPR15LG protein is highly expressed in psoriasis lesional skin and it positively regulates psoriatic keratinocyte proliferation. Our data also showed that GPR15LG could regulate the activity of NF-\u03baB pathway, which is associated with psoriatic inflammation. In the present study, we demonstrated that Gpr15lg (ortholog of GPR15LG) knockdown attenuated the severity of imiquimod (IMQ)-induced psoriasis-like inflammation in mice. Such an effect was achieved by down-regulating the expression of inflammatory cytokines interleukin (IL)-1\u03b1, IL-1\u03b2, tumor necrosis factor (TNF)-\u03b1 and S100A7. Consistently, GPR15LG knockdown in vitro significantly downgraded the expression of inflammatory factors in the cellular model of psoriasis. These results suggested that GPR15LG could be involved in the development of psoriasis by regulating inflammation.<\/jats:p>","DOI":"10.1042\/bsr20231347","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T15:52:37Z","timestamp":1708703557000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["GPR15LG regulates psoriasis-like inflammation by down-regulating inflammatory factors on keratinocytes"],"prefix":"10.1042","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7220-0322","authenticated-orcid":false,"given":"Caifeng","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology, Fujian Provincial Hospital, Clinical Medical College of Fujian Medical University, Fujian Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renhui","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Fujian Provincial Hospital, Clinical Medical College of Fujian Medical University, Fujian Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3532-2478","authenticated-orcid":false,"given":"Jun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Fujian Provincial Hospital, Clinical Medical College of Fujian Medical University, Fujian Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danqun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Fujian Provincial Hospital, Clinical Medical College of Fujian Medical University, Fujian Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Fujian Provincial Hospital, Clinical Medical College of Fujian Medical University, Fujian Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"key":"2024053110114261100_B1","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet"},{"key":"2024053110114261100_B2","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1001\/jama.2020.4006","article-title":"Pathophysiology, clinical presentation, and treatment of psoriasis: a review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"2024053110114261100_B3","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1111\/1346-8138.15840","article-title":"Psoriasis: comorbidities","volume":"48","author":"Yamazaki","year":"2021","journal-title":"J. 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