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Loss-of-function mutations in KRIT1 lead to the development of cerebral cavernous malformations (CCM), a disease marked by the formation of abnormal blood vessels which exhibit a loss of barrier function, increased endothelial proliferation, and altered gene expression. While many advances have been made in our understanding of how KRIT1, and the functionally related proteins CCM2 and PDCD10, contribute to the regulation of blood vessels and the vascular barrier, some important open questions remain. In addition, KRIT1 is widely expressed and KRIT1 and the other CCM proteins have been shown to play important roles in non-endothelial cell types and tissues, which may or may not be related to their role as pathogenic originators of CCM. In this review, we discuss some of the unsettled questions regarding the role of KRIT1 in vascular physiology and discuss recent advances that suggest this ubiquitously expressed protein may have a role beyond the endothelial cell.<\/jats:p>","DOI":"10.1042\/bsr20231675","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T11:43:31Z","timestamp":1720525411000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["KRIT1 in vascular biology and beyond"],"prefix":"10.1042","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1830-6601","authenticated-orcid":false,"given":"Angela\u00a0J.","family":"Glading","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Physiology, University of Rochester, Rochester, NY, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2024,7,19]]},"reference":[{"key":"2024072206061349800_B1","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1038\/sj.onc.1201268","article-title":"Association of Krev-1\/Rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22","volume":"15","author":"Serebriiskii","year":"1997","journal-title":"Oncogene"},{"key":"2024072206061349800_B2","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1093\/hmg\/8.12.2325","article-title":"Mutations in the Gene Encoding Krit1, a Krev-1\/Rap1a binding protein, cause cerebral cavernous malformations (Ccm1)","volume":"8","author":"Sahoo","year":"1999","journal-title":"Hum. 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