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GBM resists most chemotherapeutic agents, resulting in a high mortality rate in patients. Human mesenchymal stem cells (hMSCs), which are parts of the cancer stroma, have been shown to be involved in the development and progression of GBM. However, different sources of hMSCs might affect GBM cells differently. In the present study, we established hMSCs from placenta (PL-hMSC) and chorion (CH-hMSC) to study the effects of their released soluble factors on the proliferation, migration, invasion, gene expression, and survival of human GBM cells, U251. We found that the soluble factors derived from CH-hMSCs and PL-hMSCs suppressed the proliferation of U251 cells in a dose-dependent manner. In contrast, soluble factors derived from both hMSC sources increased U251 migration without affecting their invasive property. The soluble factors derived from these hMSCs decreased the expression levels of CyclinD1, E2Fs and MYC genes that promote GBM cell proliferation but increased the expression level of TWIST gene, which promotes EMT and GBM cell migration. The functional study suggests that both hMSCs might exert their effects, at least in part, by activating TGF-\u03b2 and suppressing Wnt\/\u03b2-catenin signaling in U251 cells. Our study provides a better understanding of the interaction between GBM cells and gestational tissue-derived hMSCs. This knowledge might be used to develop safer and more effective stem cell therapy that improves the survival and quality of life of patients with GBM by manipulating the interaction between hMSCs and GBM cells.<\/jats:p>","DOI":"10.1042\/bsr20231964","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T15:58:31Z","timestamp":1714492711000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["PL-hMSC and CH-hMSC derived soluble factors inhibit proliferation but improve hGBM cell migration by activating TGF-\u03b2 and inhibiting Wnt signaling"],"prefix":"10.1042","volume":"44","author":[{"given":"Tanawat","family":"Uthanaphun","sequence":"first","affiliation":[{"name":"1Master of Science Program in Stem Cell and Molecular Biology, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirikul","family":"Manochantr","sequence":"additional","affiliation":[{"name":"2Center of Excellence in Stem Cell Research and Innovation, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand"},{"name":"3Division of Cell Biology, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chairat","family":"Tantrawatpan","sequence":"additional","affiliation":[{"name":"2Center of Excellence in Stem Cell Research and Innovation, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand"},{"name":"3Division of Cell Biology, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duangrat","family":"Tantikanlayaporn","sequence":"additional","affiliation":[{"name":"2Center of Excellence in Stem Cell Research and Innovation, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand"},{"name":"3Division of Cell Biology, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4113-7172","authenticated-orcid":false,"given":"Pakpoom","family":"Kheolamai","sequence":"additional","affiliation":[{"name":"2Center of Excellence in Stem Cell Research and Innovation, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand"},{"name":"3Division of Cell Biology, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2024,5,17]]},"reference":[{"key":"2024051707310290600_B1","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1158\/1055-9965.EPI-14-0275","article-title":"Epidemiologic and molecular prognostic review of glioblastoma","volume":"23","author":"Thakkar","year":"2014","journal-title":"Cancer. 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