{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:38:35Z","timestamp":1753871915322,"version":"3.41.2"},"reference-count":36,"publisher":"Portland Press Ltd.","issue":"6","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010090","name":"Women and Children's Health Research Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010090","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,6,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Natural and synthetic polymeric materials, particularly soft and hard tissue replacements, are paramount in medicine. We prepared calcium-incorporated sulfonated polyether-ether ketone (SPEEK) polymer membranes for bone applications. The bioactivity was higher after 21 days of immersion in simulated body fluid (SBF) due to calcium concentration in the membrane. We present a new biomaterial healing system composed of calcium and sulfonated polyether ether ketone (Ca-SPEEK) that can function as a successful biomaterial without causing inflammation when tested on bone marrow cells. The Ca-SPEEK exhibited 13 \u00b1 0.5% clot with low fibrin mesh formation compared to 21 \u00b1 0.5% in SPEEK. In addition, the Ca-SPEEK showed higher protein adsorption than SPEEK membranes. As an inflammatory response, IL-1 and TNF-\u03b1 in the case of Ca-SPEEK were lower than those for SPEEK. We found an early regulation of IL-10 in the case of Ca-SPEEK at 6 h, which may be attributed to the down-regulation of the inflammatory markers IL-1 and TNF-\u03b1. These results evidence the innovative bioactivity of Ca-SPEEK with low inflammatory response, opening venues for bone applications.<\/jats:p>","DOI":"10.1042\/bsr20232162","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T08:29:21Z","timestamp":1717576161000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bioactivity, hemocompatibility, and inflammatory response of calcium incorporated sulfonated polyether ether ketone on mouse-derived bone marrow cells"],"prefix":"10.1042","volume":"44","author":[{"given":"Shanmuga\u00a0Sundar","family":"Saravanabhavan","sequence":"first","affiliation":[{"name":"1Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada"},{"name":"2Department of Biotechnology, Aarupadai Veedu Institute of Technology, VMRF (DU), Paiyanoor, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabhu","family":"Narayanaswamy Venkatesan","sequence":"additional","affiliation":[{"name":"3Department of Chemistry, Easwari Engineering College, Ramapuram, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narendranath","family":"Jonna","sequence":"additional","affiliation":[{"name":"4Centre for Energy Storage Technology, Anna University, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamalakannan","family":"Vasantha Palaniappan","sequence":"additional","affiliation":[{"name":"4Centre for Energy Storage Technology, Anna University, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Sarang","sequence":"additional","affiliation":[{"name":"5Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balasubramanian","family":"Natesan","sequence":"additional","affiliation":[{"name":"4Centre for Energy Storage Technology, Anna University, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2779-7879","authenticated-orcid":false,"given":"Consolato\u00a0M.","family":"Sergi","sequence":"additional","affiliation":[{"name":"1Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada"},{"name":"6Division of Anatomic Pathology, Children's Hospital of Eastern Ontario, University of Ottawa, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"key":"2024062607012372800_B1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.20469\/ijaps.6.50003","article-title":"Forming and coating of hydroxyapatite on PEEK substrate for orthopedic implants","volume":"6","author":"Yutitum","year":"2020","journal-title":"Int. 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