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In this study, five polysaccharide fractions, labeled pSFP-1-5, were isolated and purified from Sargassum fusiforme (S. fusiforme). In vitro experiments demonstrated that pSFP-5 significantly prevented the binding of type A, B and H histo-blood group antigens (HBGAs) to NoV GII.4 virus-like particles (NoV GII.4 VLPs). In addition, in vivo experiments revealed that pSFP-5 was effective in reducing the accumulation of NoV in oysters, indicating that pSFP-5 could reduce the risk of NoV infection from oyster consumption. The results of transmission electron microscopy showed that the appearance of NoV GII.4 VLPs changed after pSFP-5 treatment, indicating that pSFP-5 may achieve antiviral ability by altering the morphological structure of the viral particles so that they could not bind to HBGAs. The results of the present study indicate that pSFP-5 may be an effective anti-NoV substance and can be used as a potential anti-NoV drug component.<\/jats:p>","DOI":"10.1042\/bsr20240092","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T06:47:36Z","timestamp":1724050056000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Inhibition of Norovirus GII.4 binding to HBGAs by\n                    <i>Sargassum fusiforme<\/i>\n                    polysaccharide"],"prefix":"10.1042","volume":"44","author":[{"given":"Yiqiang","family":"Sun","sequence":"first","affiliation":[{"name":"1College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China"},{"name":"2Zhejiang Provincial Key Laboratory for Water Environment and Marine Biological Resources Protection, Wenzhou University, Wenzhou 325035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meina","family":"Liang","sequence":"additional","affiliation":[{"name":"1College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China"},{"name":"2Zhejiang Provincial Key Laboratory for Water Environment and Marine Biological Resources Protection, Wenzhou University, Wenzhou 325035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjiang","family":"Wu","sequence":"additional","affiliation":[{"name":"1College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China"},{"name":"2Zhejiang Provincial Key Laboratory for Water Environment and Marine Biological Resources Protection, Wenzhou University, Wenzhou 325035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5725-2802","authenticated-orcid":false,"given":"Laijin","family":"Su","sequence":"additional","affiliation":[{"name":"1College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China"},{"name":"2Zhejiang Provincial Key Laboratory for Water Environment and Marine Biological Resources Protection, Wenzhou University, Wenzhou 325035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2024,9,10]]},"reference":[{"key":"2024091013155575100_B1","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.3201\/eid1410.080117","article-title":"Norwalk virus shedding after experimental human infection","volume":"14","author":"Atmar","year":"2008","journal-title":"Emerg. 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