{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T03:59:44Z","timestamp":1783742384945,"version":"3.55.0"},"reference-count":52,"publisher":"Portland Press Ltd.","issue":"10","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["91849120, 32271155, 31871154, and 81402917"],"award-info":[{"award-number":["91849120, 32271155, 31871154, and 81402917"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Science Foundation of Hebei Province of China","award":["C2020206025"],"award-info":[{"award-number":["C2020206025"]}]},{"name":"University level Graduate Innovation Funding Project of Hebei Medical University in 2023","award":["XCXZZB202303"],"award-info":[{"award-number":["XCXZZB202303"]}]}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Aging is an inevitable and irreversible biological process that gradually heightens the risks of various diseases and death. As a newly discovered endogenous gasotransmitter, hydrogen sulfide (H2S) has been identified to exert multiple beneficial impacts on the regulation of aging and age-related pathologies. This study was aimed at systematically exploring the relationship between asynchronous aging processes and H2S concentrations in various tissues of aging mice. Samples of plasma and 13 tissues were collected from four cross-sectional age groups (3, 6, 12 and 18 months of age) covering the lifespan of male C57BL\/6J mice. The H2S concentration was quantified by a reported liquid chromatography-tandem mass spectrometry (LC-MS\/MS) method with monobromobimane derivatization. Additionally, the expressions of cystathionine \u03b3-lyase (CSE), cystathionine \u03b2-synthase and 3-mercaptopyruvate sulfurtransferase, in those tissues were analyzed by Western blotting. We discovered that the H2S concentrations decreased asynchronously with the aging process in plasma, heart, liver, kidney, spleen, subcutaneous fat and brown fat and increased in brain and lung. At least one of the three H2S-generating enzymes expressions was compensatorily up-regulated with the aging process in most tissues, among which the up-regulation of CSE was the most prominent.<\/jats:p>","DOI":"10.1042\/bsr20240320","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T15:14:40Z","timestamp":1727104480000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Asynchronous changes of hydrogen sulfide and its generating enzymes in most tissues with the aging process"],"prefix":"10.1042","volume":"44","author":[{"given":"Kaichuan","family":"He","sequence":"first","affiliation":[{"name":"1Department of Physiology, Hebei Medical University, Hebei 050017, China"},{"name":"2Center for Clinical Medical Research, Hebei Genral Hospital, Hebei 050051, China"},{"name":"3Hebei Key Laboratory of Metabolic Diseases, Hebei Genral Hospital, Hebei 050051, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Tan","sequence":"additional","affiliation":[{"name":"4Clinical Pharmacokinetic Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao","family":"Lu","sequence":"additional","affiliation":[{"name":"1Department of Physiology, Hebei Medical University, Hebei 050017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Bai","sequence":"additional","affiliation":[{"name":"1Department of Physiology, Hebei Medical University, Hebei 050017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengqing","family":"Song","sequence":"additional","affiliation":[{"name":"1Department of Physiology, Hebei Medical University, Hebei 050017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Miao","sequence":"additional","affiliation":[{"name":"1Department of Physiology, Hebei Medical University, Hebei 050017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biyu","family":"Liu","sequence":"additional","affiliation":[{"name":"1Department of Physiology, Hebei Medical University, Hebei 050017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Chen","sequence":"additional","affiliation":[{"name":"1Department of Physiology, Hebei Medical University, Hebei 050017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Teng","sequence":"additional","affiliation":[{"name":"1Department of Physiology, Hebei Medical University, Hebei 050017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Dai","sequence":"additional","affiliation":[{"name":"5Department of Clinical Diagnostics, Hebei Medical University, Hebei 050017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3282-056X","authenticated-orcid":false,"given":"Yuming","family":"Wu","sequence":"additional","affiliation":[{"name":"1Department of Physiology, Hebei Medical University, Hebei 050017, China"},{"name":"6Hebei Collaborative Innovation Center for Cardio-Cerebrovascular Disease, Hebei 050017, China"},{"name":"7The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Shijiazhuang 050017, China"},{"name":"8Hebei Key Laboratory of Cardiovascular Homeostasis and Aging, Shijiazhuang 050017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2024,10,11]]},"reference":[{"key":"2024101107204066700_B1","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1134\/S000629792101003X","article-title":"Terminal oxidase cytochrome bd protects bacteria against hydrogen sulfide toxicity","volume":"13","author":"Borisov","year":"2021","journal-title":"Biochem. 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