{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T21:45:02Z","timestamp":1755035102228,"version":"3.41.2"},"reference-count":46,"publisher":"Portland Press Ltd.","issue":"7","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Technology, Taiwan","award":["105-2628-B-075-001-MY3"],"award-info":[{"award-number":["105-2628-B-075-001-MY3"]}]}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background: Portal hypertension affects hepatic, splanchnic and portosystemic collateral systems. Although alcohol is a well-known risk factor for liver cirrhosis, it also affects vascular contractility. However, the relevant effects on portal hypertension have not been evaluated in non-alcoholic cirrhosis. The present study aimed to investigate the impacts of low-dose alcohol on portal hypertension-related derangements in non-alcoholic cirrhotic rats.<\/jats:p>\n               <jats:p>Methods: Sprague-Dawley rats received bile duct ligation to induce cirrhosis or sham operation as controls. The chronic or acute effects of low-dose alcohol (2.4 g\/kg\/day, oral gavage, approximately 1.3 drinks\/day in humans) were evaluated.<\/jats:p>\n               <jats:p>Results: The chronic administration of low-dose alcohol did not precipitate liver fibrosis in the sham or cirrhotic rats; however, it significantly increased splanchnic blood inflow (P=0.034) and portosystemic collaterals (P=0.001). Mesenteric angiogenesis and pro-angiogenic proteins were up-regulated in the alcohol-treated cirrhotic rats, and poorer collateral vasoresponsiveness to vasoconstrictors (P&amp;lt;0.001) was noted. Consistently, acute alcohol administration reduced splenorenal shunt resistance. Collateral vasoresponsiveness to vasoconstrictors also significantly decreased (P=0.003).<\/jats:p>\n               <jats:p>Conclusions: In non-alcoholic cirrhosis rats, a single dose of alcohol adversely affected portosystemic collateral vessels due to vasodilatation. Long-term alcohol use precipitated splanchnic hyperdynamic circulation, in which mesenteric angiogenesis played a role. Further studies are warranted to evaluate the benefits of avoiding low-dose alcohol consumption in patients with non-alcoholic cirrhosis.<\/jats:p>","DOI":"10.1042\/bsr20240354","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T09:36:10Z","timestamp":1720172170000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Low-dose alcohol exacerbates hyperdynamic circulation and shunting in non-alcoholic cirrhotic rats"],"prefix":"10.1042","volume":"44","author":[{"given":"Chon\u00a0Kit","family":"Pun","sequence":"first","affiliation":[{"name":"1School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"2Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Chun","family":"Huang","sequence":"additional","affiliation":[{"name":"1School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"2Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5526-5389","authenticated-orcid":false,"given":"Ching-Chih","family":"Chang","sequence":"additional","affiliation":[{"name":"1School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"3Division of Holistic and Multidisciplinary Medicine, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4884-634X","authenticated-orcid":false,"given":"Shao-Jung","family":"Hsu","sequence":"additional","affiliation":[{"name":"1School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"2Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiao-Lin","family":"Chuang","sequence":"additional","affiliation":[{"name":"1School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"4Division of General Medicine, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Hsiang","family":"Huang","sequence":"additional","affiliation":[{"name":"1School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"2Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Chih","family":"Hou","sequence":"additional","affiliation":[{"name":"1School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"2Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fa-Yauh","family":"Lee","sequence":"additional","affiliation":[{"name":"1School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"2Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2024,7,19]]},"reference":[{"key":"2024072206061518600_B1","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1002\/hep.25625","article-title":"Cannabinoid receptor 2 agonist ameliorates mesenteric angiogenesis and portosystemic collaterals in cirrhotic rats","volume":"56","author":"Huang","year":"2012","journal-title":"Hepatology"},{"key":"2024072206061518600_B2","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1002\/hep.27679","article-title":"Caffeine ameliorates hemodynamic derangements and portosystemic collaterals in cirrhotic rats","volume":"61","author":"Hsu","year":"2015","journal-title":"Hepatology"},{"key":"2024072206061518600_B3","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1016\/j.jhep.2019.12.021","article-title":"Total area of spontaneous portosystemic shunts independently predicts hepatic encephalopathy and mortality in liver cirrhosis","volume":"72","author":"Praktiknjo","year":"2020","journal-title":"J. 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