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UC is the most common form of inflammatory bowel disease (IBD). The current treatment for mild-to-moderate UC involves the use of 5-aminosalicylates (5-ASA), but much of this compound is unabsorbed and metabolized by N-acetylation. Several efforts have since been made to evaluate new molecules from synthetic or natural sources. Recently, it was reported that (E)-(5-chloro-2-hydroxy)-\u03b1-aminocinnamic acid (2c) and (E)-(2,4-dihydroxy)-\u03b1-aminocinnamic acid (2f) are as good or better myeloperoxidase (MPO) inhibitors and antioxidants than 5-ASA. Then, the present study aimed to evaluate the protective effects of 2c and 2f on a rat model of UC induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS). The results showed that TNBS caused the induction of colonic ulcers, as well as a significant increase in MPO activity and malondialdehyde (MDA) and a decrease in glutathione (GSH) content. The administration of 2f, 2c and 5-ASA, decreased the ulcers presence, inhibited MPO peroxidation activity and MPO presence (as determined by immunofluorescence), and increased GSH and reduced MDA content. However, 2f was better than 2c and 5-ASA, then, the principal mechanism by which 2f presented a protective effect in a UC model induced by TNBS in rats is by inhibiting MPO activity and due to its antioxidant activity.<\/jats:p>","DOI":"10.1042\/bsr20240797","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T08:53:18Z","timestamp":1726217598000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Protective effect of (<i>E<\/i>)-(2,4-dihydroxy)-\u03b1-aminocinnamic acid, a hydroxy cinnamic acid derivative, in an ulcerative colitis model induced by TNBS"],"prefix":"10.1042","volume":"44","author":[{"given":"Astrid\u00a0Mayleth","family":"Rivera Antonio","sequence":"first","affiliation":[{"name":"1Laboratorio de Biof\u00edsica y Biocat\u00e1lisis, Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y Salvador D\u00edaz Mir\u00f3n s\/n, Casco de Santo Tomas, Ciudad de M\u00e9xico 11340, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itzia\u00a0Irene","family":"Padilla Mart\u00ednez","sequence":"additional","affiliation":[{"name":"2Laboratorio de Qu\u00edmica Supramolecular y Nanociencias, Unidad Profesional Interdisciplinaria de Biotecnolog\u00eda, Instituto Polit\u00e9cnico Nacional, Avenida Acueducto s\/n, Barrio la Laguna Ticom\u00e1n, Ciudad de M\u00e9xico 07340, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazm\u00edn\u00a0Karina","family":"M\u00e1rquez-Flores","sequence":"additional","affiliation":[{"name":"3Departamento de Farmacia, Escuela Nacional de Ciencias Biol\u00f3gicas, Campus Zacatenco, Instituto Polit\u00e9cnico Nacional, Av. Wilfrido Massieu s\/n Col. Zacatenco, C.P. 07738, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan\u00a0Hip\u00f3lito","family":"Ju\u00e1rez Solano","sequence":"additional","affiliation":[{"name":"4Direcci\u00f3n de investigaci\u00f3n del Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Su\u00e1rez. Av. Insurgentes sur #3877, col. La Fama. Tlalpan, Ciudad de M\u00e9xico. C.P. 14269. M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica\u00a0A.","family":"Torres Ramos","sequence":"additional","affiliation":[{"name":"4Direcci\u00f3n de investigaci\u00f3n del Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Su\u00e1rez. Av. Insurgentes sur #3877, col. La Fama. Tlalpan, Ciudad de M\u00e9xico. C.P. 14269. M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0012-580X","authenticated-orcid":false,"given":"Martha\u00a0Cecilia","family":"Rosales Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"1Laboratorio de Biof\u00edsica y Biocat\u00e1lisis, Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y Salvador D\u00edaz Mir\u00f3n s\/n, Casco de Santo Tomas, Ciudad de M\u00e9xico 11340, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2024,10,4]]},"reference":[{"key":"2024100410060246600_B1","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1016\/j.biopha.2018.09.081","article-title":"Oenothera rosea L\u00b4H\u00e9r. ex Ait attenuates acute colonic inflammation in TNBS-induced colitis model in rats: in vivo and in silico myeloperoxidase role","volume":"108","author":"Calva-Candelaria","year":"2018","journal-title":"Biomed. 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