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Despite extensive research efforts, effective treatments that can halt or reverse the progression of PD remain elusive. In recent years, nanotechnology has emerged as a promising new avenue for addressing this challenge, with zinc oxide nanoparticles (ZnO-NPs) standing out for their extensive therapeutic potential. ZnO-NPs have shown remarkable promise in neuroprotection through several key mechanisms. The multifaceted properties of ZnO-NPs suggest that they could play a crucial role in intervening across various fundamental mechanisms implicated in PD. By targeting these mechanisms, ZnO-NPs offer new insights and potential strategies for managing and treating PD. This review aims to provide a thorough examination of the molecular mechanisms through which ZnO-NPs exert their neuroprotective effects. It highlights their potential as innovative therapeutic agents for PD and outlines directions for future research to explore and harness their full capabilities.<\/jats:p>","DOI":"10.1042\/bsr20241102","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T07:04:36Z","timestamp":1730876676000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Neuroprotective properties of zinc oxide nanoparticles: therapeutic implications for Parkinson's disease"],"prefix":"10.1042","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2153-7184","authenticated-orcid":false,"given":"Kim\u00a0San","family":"Tang","sequence":"first","affiliation":[{"name":"1School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley\u00a0Zhi\u00a0Chung","family":"See","sequence":"additional","affiliation":[{"name":"2Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Naidu","sequence":"additional","affiliation":[{"name":"2Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"2024110607042803500_B1","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1016\/j.cmet.2018.05.011","article-title":"Hallmarks of brain aging: adaptive and pathological modification by metabolic states","volume":"27","author":"Mattson","year":"2018","journal-title":"Cell Metab."},{"key":"2024110607042803500_B2","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.3390\/ijms23031851","article-title":"A review of the common neurodegenerative disorders: current therapeutic approaches and the potential role of nanotherapeutics","volume":"23","author":"Lamptey","year":"2022","journal-title":"Int. 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