{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T09:41:06Z","timestamp":1781602866608,"version":"3.54.5"},"reference-count":43,"publisher":"Portland Press Ltd.","issue":"02","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32271155, 91849120 and 31871154"],"award-info":[{"award-number":["32271155, 91849120 and 31871154"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Natural Science Foundation of Hebei Province of China","award":["C2020206025"],"award-info":[{"award-number":["C2020206025"]}]},{"name":"the Hebei Province Government Grant","award":["CXZZBS2019108"],"award-info":[{"award-number":["CXZZBS2019108"]}]},{"name":"the Medical Science Research Project of Health Commission of Hebei Province","award":["20210612"],"award-info":[{"award-number":["20210612"]}]}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,2,28]]},"abstract":"<jats:p>Sepsis-induced cardiac dysfunction is one of the most common complications of sepsis. It is also a major cause of death in pediatric intensive care units. The underlying mechanism of sepsis-induced cardiac dysfunction remains elusive. Cold-inducible RNA-binding protein (CIRP) is a damage-associated molecular pattern that is up-regulated during sepsis. Hydrogen sulfide (H2S) has been shown to play a protective role in sepsis-induced cardiac dysfunction in adult animals. The present study aimed to determine whether H2S ameliorates the cardiac function in infant rats by inhibiting CIRP-mediated sepsis-induced cardiac dysfunction. Rat pups aged 17\u201318 days were subjected to cecal ligation and puncture (CLP) to induce sepsis. Six hours after CLP, hemodynamic results demonstrated that there was a significant decrease in +dP\/dtmax, \u2212dP\/dtmax, left ventricular ejection fraction, and left ventricular shortening fraction, indicating cardiac dysfunction. The plasma levels of myocardial injury markers such as creatine kinase\u2013myocardial band and cardiac troponin I were significantly increased at 6 h after CLP. The inhibition of CIRP with C23 improved the cardiac function of the rats with CLP-induced sepsis, accompanied by a significant decrease in endoplasmic reticulum stress (ERS) activation. Moreover, treatment with sodium 4-phenylbutyrate (an inhibitor of ERS) ameliorated myocardial injury and dysfunction, accompanied by a significant decrease in ERS activation. Sodium hydrosulfide, a H2S donor, ameliorated CLP-induced cardiac dysfunction and decreased CIRP levels and ERS. In contrast, the inhibition of endogenous H2S production by propargylglycine (a cystathionine-\u03b3-lyase inhibitor) aggravated CLP-induced cardiac dysfunction and increased CIRP levels. In conclusion, the present study demonstrated that H2S exerted cardioprotective effects by inhibiting the CIRP\/ERS pathway in infant rats with sepsis. These findings might indicate a novel target in the treatment of sepsis in infants.<\/jats:p>","DOI":"10.1042\/bsr20241398","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T10:50:11Z","timestamp":1738752611000},"page":"141-155","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hydrogen sulfide attenuates sepsis-induced cardiac dysfunction in infant rats by inhibiting the expression of cold-inducible RNA-binding protein"],"prefix":"10.1042","volume":"45","author":[{"given":"Desi","family":"Li","sequence":"first","affiliation":[{"name":"1Department of Physiology, Hebei Medical University, Hebei 050017, China"},{"name":"2Department of Medical, Hebei Medical University Third Hospital, Hebei 050051, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Jin","sequence":"additional","affiliation":[{"name":"1Department of Physiology, Hebei Medical University, Hebei 050017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Teng","sequence":"additional","affiliation":[{"name":"1Department of Physiology, Hebei Medical University, Hebei 050017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"1Department of Physiology, Hebei Medical University, Hebei 050017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaichuan","family":"He","sequence":"additional","affiliation":[{"name":"3Clinical Medicine Research Center, Hebei General Hospital, Hebei 050051, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijing","family":"Cao","sequence":"additional","affiliation":[{"name":"4Department of Pediatric Intensive Care Unit, Hebei Children\u2019s Hospital, Hebei 050031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiexian","family":"Du","sequence":"additional","affiliation":[{"name":"5Gynecology and Obstetrics, The Second Hospital of Hebei Medical University, Hebei 050000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Guo","sequence":"additional","affiliation":[{"name":"1Department of Physiology, Hebei Medical University, Hebei 050017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Xiao","sequence":"additional","affiliation":[{"name":"1Department of Physiology, Hebei Medical University, Hebei 050017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Xue","sequence":"additional","affiliation":[{"name":"1Department of Physiology, Hebei Medical University, Hebei 050017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyang","family":"Tian","sequence":"additional","affiliation":[{"name":"1Department of Physiology, Hebei Medical University, Hebei 050017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuixia","family":"An","sequence":"additional","affiliation":[{"name":"6Department of Psychiatry, The First Hospital of Hebei Medical University, Hebei 050000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3282-056X","authenticated-orcid":false,"given":"Yuming","family":"Wu","sequence":"additional","affiliation":[{"name":"1Department of Physiology, Hebei Medical University, Hebei 050017, China"},{"name":"7Hebei Collaborative Innovation Center for Cardio-Cerebrovascular Disease, Hebei 050031, China"},{"name":"8The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei 050017, China"},{"name":"9Hebei Key Laboratory of Cardiovascular Homeostasis and Aging, Hebei 050017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"2025022710374923600_BSR-2024-1398C1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1001\/jama.2024.0179","article-title":"International consensus criteria for pediatric sepsis and septic shock","volume":"331","author":"Schlapbach","year":"2024","journal-title":"JAMA"},{"key":"2025022710374923600_BSR-2024-1398C2","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1164\/rccm.200207-682OC","article-title":"The epidemiology of severe sepsis in children in the United States","volume":"167","author":"Watson","year":"2003","journal-title":"Am. 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