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The present study highlights the potential of purslane seed oil extract-Pluronic-modulated liposomes (PSE-PMLs) to protect against thioacetamide (TAA)-induced ALF in rats. Four groups of rats were used in the present study: normal control (NC), TAA-induced ALF, silymarin (SIL), and PSE-PML groups. SIL- and PSE-PML-pretreated groups were orally pre-administered SIL (200\u00a0mg\/kg) and PSE-PMLs (500\u00a0mg\/kg), respectively, for 7\u00a0days. After these pretreatments, all groups except the NC group were injected intraperitoneally with TAA (350\u00a0mg\/kg) to induce ALF. Serum levels of liver biochemical markers and inflammatory cytokines, interleukin-4, and interferon-gamma were estimated. Additionally, the hepatic malondialdehyde, superoxide dismutase activity, peroxisome proliferator-activated receptor-gamma coactivator 1-alpha, phosphorylated Janus kinase 2, phosphorylated signal transducer and activator of transcription 3, peroxisome proliferator-activated receptor-gamma, tumor protein p53, active cysteine-aspartic acid protease 3, and B-cell lymphoma 2 were assessed. A histopathological examination of the liver was also performed. The study found that pretreatment with PSE-PMLs mitigated TAA-induced biochemical and histopathological alterations, alleviating oxidative stress, dampening the overproduction of pro-inflammatory cytokines, and amending liver cell apoptosis. These pioneering findings suggest that PSE-PMLs are a promising prophylactic agent against ALF, warranting further studies in the post-injury models. The phytochemical profiling, gas chromatography\u2013mass spectrometry, of purslane seed oil revealed \u03b1-linolenic acid (\u223c98%) as the predominant component, with additional sterols, tocopherols, and phenolic acids that may underlie its strong antioxidant and hepatoprotective effects.<\/jats:p>","DOI":"10.1042\/bsr20250383","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T17:23:56Z","timestamp":1774545836000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["\u03b1-Linolenic acid-driven nano-liposomes from purslane seed oil modulate p-JAK2\/p-STAT3 to combat acute liver failure"],"prefix":"10.1042","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0855-5580","authenticated-orcid":false,"given":"Shimaa\u00a0O.","family":"Ali","sequence":"first","affiliation":[{"name":"1Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doaa","family":"Hegazy","sequence":"additional","affiliation":[{"name":"2Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim\u00a0S.","family":"Kamel","sequence":"additional","affiliation":[{"name":"3Medical Laboratory program, Faculty of Applied Health Sciences, East Port Said National University, Port Said, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naglaa\u00a0H.","family":"Shalan","sequence":"additional","affiliation":[{"name":"4Department of Pathology, Faculty of Medicine, Banha University, Banha, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa\u00a0A.","family":"ElMonier","sequence":"additional","affiliation":[{"name":"1Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"2026050810110815300_B1","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.jhep.2020.09.003","article-title":"Liver zonation","volume":"74","author":"Manco","year":"2021","journal-title":"J. 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