{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T07:56:13Z","timestamp":1781769373870,"version":"3.54.5"},"reference-count":29,"publisher":"Portland Press Ltd.","issue":"7","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002081","name":"Irish Research Council","doi-asserted-by":"publisher","award":["GOIPG\/2022\/426"],"award-info":[{"award-number":["GOIPG\/2022\/426"]}],"id":[{"id":"10.13039\/501100002081","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Prenatal stress is associated with deleterious neurodevelopmental consequences in affected offspring. Prenatal stress via exposure to high physiological levels of inflammation in utero may induce an inflammatory state in the fetal brain. However, inflammation is not only associated with disease-states but also can be seen in a healthy pregnancy. There is limited research examining the potential that exposure to biological mediators of stress may have on neurodevelopment. We aim to determine whether certain circulating biological markers in maternal serum influence neurite growth in partially differentiated SH-SY5Y cells as a potential mechanism impacting neurodevelopment. Blood was collected at 20-weeks\u2019 gestation as part of the SCOPE pregnancy cohort study. These factors, including pro-inflammatory cytokines, markers of tryptophan metabolism, and gut permeability that were previously analysed, were used to stratify women into low (n\u00a0=\u00a010) and high (n\u00a0=\u00a010) biological stress groups. Exposure to the serum categorised as \u2018high-stress\u2019 significantly reduced neurite length in comparison to serum categorised as \u2018low-stress\u2019, with tumour necrosis factor-\u03b1 playing a substantial role in mediating this reduction. The \u2018high-stress\u2019 serum was subsequently found to increase the levels of phospho-Ser536-p65. Phosphorylation of p65 Ser536 has previously been shown to switch NF-\u03ba\u0392 from promoting neuronal growth, to inhibiting it. The reduction in neurite length seen following exposure to the \u2018high-stress\u2019 serum was prevented when NF-\u03ba\u0392 p65 was knocked down. The present study emphasises the potential negative impact that circulating factors may have on neuronal growth, and the mechanism behind it.<\/jats:p>","DOI":"10.1042\/bsr20260125","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T05:00:12Z","timestamp":1779771612000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal serum from \u2018high-stress\u2019 pregnancies demonstrates bioactivity capable of attenuating neurite growth through a TNF\u03b1-dependent pathway in SH-SY5Y cells"],"prefix":"10.1042","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8857-3783","authenticated-orcid":false,"given":"Clara","family":"Deady","sequence":"first","affiliation":[{"name":"1Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland"},{"name":"2APC Microbiome Ireland, University College Cork, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Wilmes","sequence":"additional","affiliation":[{"name":"1Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland"},{"name":"2APC Microbiome Ireland, University College Cork, Cork, Ireland"},{"name":"3Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5062-6851","authenticated-orcid":false,"given":"Fergus\u00a0P.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"4Department of Obstetrics and Gynaecology, University College Cork, Cork, Ireland"},{"name":"5INFANT Research Centre, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali\u00a0S.","family":"Khashan","sequence":"additional","affiliation":[{"name":"5INFANT Research Centre, Cork, Ireland"},{"name":"6School of Public Health, University College Cork, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9771-3979","authenticated-orcid":false,"given":"Gerard","family":"Clarke","sequence":"additional","affiliation":[{"name":"2APC Microbiome Ireland, University College Cork, Cork, Ireland"},{"name":"3Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland"},{"name":"5INFANT Research Centre, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7640-8326","authenticated-orcid":false,"given":"James","family":"Keane","sequence":"additional","affiliation":[{"name":"2APC Microbiome Ireland, University College Cork, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9514-9021","authenticated-orcid":false,"given":"Cathal","family":"McCarthy","sequence":"additional","affiliation":[{"name":"7Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5149-0933","authenticated-orcid":false,"given":"Gerard\u00a0W.","family":"O\u2019Keeffe","sequence":"additional","affiliation":[{"name":"1Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland"},{"name":"2APC Microbiome Ireland, University College Cork, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9597-9391","authenticated-orcid":false,"given":"Siobhain\u00a0M.","family":"O\u2019Mahony","sequence":"additional","affiliation":[{"name":"1Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland"},{"name":"2APC Microbiome Ireland, University College Cork, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"2026061803463782100_B1","doi-asserted-by":"publisher","first-page":"105793","DOI":"10.1016\/j.neubiorev.2024.105793","article-title":"Prenatal stress impacts foetal neurodevelopment: temporal windows of gestational vulnerability","volume":"164","author":"Collins","year":"2024","journal-title":"Neurosci. 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