{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:35:20Z","timestamp":1760985320400},"reference-count":0,"publisher":"Portland Press Ltd.","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,10,1]]},"abstract":"<jats:p>The implementation of highly sensitive and rapid mass spectrometric screening strategies for defining the glycosylation repertoires of organs in knockout mice is helping to reveal the roles that glycans play in health and disease. Thus novel glycosylation pathways have been uncovered in two such knockouts, namely \u03b1-mannosidase II null mice and UDP-N-acetylglucosamine:\u03b16-d-mannoside\u03d01,2-N-acetylglucosaminyltransferase II null mice. This chapter documents the glycosylation profiles of a wide range of organs from the normal mouse which should facilitate future glycomics studies of knockout mice. Furthermore, we report applications of our screening technology in studies of the myodystrophy mouse and a human leukodystrophy.<\/jats:p>","DOI":"10.1042\/bss0690105","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T19:14:31Z","timestamp":1439234071000},"page":"105-115","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["MS screening strategies: investigating the glycomes of knockout and myodystrophic mice and leukodystrophic human brains"],"prefix":"10.1042","volume":"69","author":[{"given":"Mark","family":"Sutton-Smith","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Imperial College of Science, Technology and Medicine, London SW7 2AY, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard R.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Imperial College of Science, Technology and Medicine, London SW7 2AY, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabhjit K.","family":"Grewal","sequence":"additional","affiliation":[{"name":"Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane E.","family":"Hewitt","sequence":"additional","affiliation":[{"name":"Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reginald E.","family":"Bittner","sequence":"additional","affiliation":[{"name":"Neuromuscular Research Department, Institute of Anatomy, University of Vienna, Waehringerstrasse 13, 1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehud","family":"Goldin","sequence":"additional","affiliation":[{"name":"National Institutes of Health, Building 10, 9000 Rockville Pike, Bethesda, MD 20892-1260, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael","family":"Schiffmann","sequence":"additional","affiliation":[{"name":"National Institutes of Health, Building 10, 9000 Rockville Pike, Bethesda, MD 20892-1260, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Dell","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Imperial College of Science, Technology and Medicine, London SW7 2AY, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Biochemical Society Symposia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemsocsymp\/article-pdf\/doi\/10.1042\/bss0690105\/837729\/bss0690105.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemsocsymp\/article-pdf\/doi\/10.1042\/bss0690105\/837729\/bss0690105.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T08:25:40Z","timestamp":1637051140000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemsocsymp\/article\/doi\/10.1042\/bss0690105\/95324\/MS-screening-strategies-investigating-the-glycomes"}},"subtitle":[],"editor":[{"given":"Kurt","family":"Drickamer","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Anne","family":"Dell","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2002,10,1]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1042\/bss0690105","relation":{},"ISSN":["0067-8694","1744-1439"],"issn-type":[{"value":"0067-8694","type":"print"},{"value":"1744-1439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,10,1]]}}}