{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:49:24Z","timestamp":1790920164308,"version":"4.1.0"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,8,1]]},"abstract":"<jats:p>Several genetic defects in class switch recombination, which lead to a hyper-IgM syndrome, have been described recently in humans. In addition to the well known role of CD40-ligand-CD40 interaction, these pathologies demonstrate definitively the requirement of CD40-mediated nuclear factor kB activation and the essential role of a recently described molecule, the activationinduced cytidine deaminase in an efficient humoral response, which includes class switch recombination and the production of high-affinity antibodies.<\/jats:p>","DOI":"10.1042\/bst0300815","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T09:39:54Z","timestamp":1088069994000},"page":"815-818","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Hyper-IgM syndromes: a model for studying the regulation of class switch recombination and somatic hypermutation generation"],"prefix":"10.1042","volume":"30","author":[{"given":"A.","family":"Durandy","sequence":"first","affiliation":[{"name":"Inserm U429, H\u00f4pital Necker-Enfants Malades, 149 Rue de S\u00e8vres, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Biochemical Society Transactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article-pdf\/30\/4\/815\/536073\/bst0300815.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article-pdf\/30\/4\/815\/536073\/bst0300815.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T21:36:11Z","timestamp":1637184971000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article\/30\/4\/815\/64863\/Hyper-IgM-syndromes-a-model-for-studying-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,8,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bst0300815","relation":{},"ISSN":["0300-5127","1470-8752"],"issn-type":[{"value":"0300-5127","type":"print"},{"value":"1470-8752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,8,1]]}}}